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CAS No.: | 35730-09-7 |
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Name: | 2,5-Difluorobenzoyl chloride |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C7H3ClF2O |
Molecular Weight: | 176.55 |
Synonyms: | 2,5-Difluorobenzoylchloride;2,5-Difluorobenzoyl chloride; |
EINECS: | 252-701-8 |
Density: | 1.42 g/cm3 |
Melting Point: | 73-74 °C |
Boiling Point: | 183.8 °C at 760 mmHg |
Flash Point: | 64.9 °C |
Appearance: | clear colorless liquid |
Hazard Symbols: | C |
Risk Codes: | 34 |
Safety: | 45-36/37/39-25-26 |
Transport Information: | UN 2920 |
PSA: | 17.07000 |
LogP: | 2.34380 |
2,5-difluorobenzoic acid
2,5-difluorobenzoyl chloride
Conditions | Yield |
---|---|
Stage #1: 2,5-difluorobenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h; | 100% |
With thionyl chloride Heating; | 97% |
With sulfuryl dichloride for 4h; Heating; | 73% |
para-difluorobenzene
2,5-difluorobenzoyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) sec-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 15 min, b) from -78 deg C to RT 2: 73 percent / SO2Cl / 4 h / Heating View Scheme |
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 4h; | 100% |
In dichloromethane at 20℃; for 0 - 20h; | 97% |
In dichloromethane at 0 - 20℃; |
ethyl (E)-3-(dimethylamino)acrylate
2,5-difluorobenzoyl chloride
ethyl 2-(2,5-difluorobenzoyl)-3-(dimethylamino)acrylate
Conditions | Yield |
---|---|
With triethylamine In toluene at 90℃; for 2h; | 100% |
2,5-difluorobenzoyl chloride
1,3,4,6-tetra-O-acetyl-β-D-galactopyranose
1,3,4,6-tetra-O-acetyl-2-O-(2,5-difluorobenzoyl)-β-D-galactopyranose
Conditions | Yield |
---|---|
With pyridine; dmap for 18h; | 96% |
Conditions | Yield |
---|---|
With pyridine In tetrahydrofuran at 0℃; for 0.166667h; | 96% |
2,5-difluorobenzoyl chloride
2,6-dibromo-4-aminophenol
N-(3,5-dibromo-4-hydroxyphenyl)-2,5-difluorobenzamide
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1h; | 95% |
1-methyl-2-indolinethione
2,5-difluorobenzoyl chloride
2-fluoro-6-methylthiochromeno[2,3-b]indol-11(6H)-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 85℃; for 5h; Inert atmosphere; | 95% |
1-phenylindoline-2-thione
2,5-difluorobenzoyl chloride
2-fluoro-6-phenylthiochromeno[2,3-b]indol-11(6H)-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20 - 85℃; for 5h; Inert atmosphere; | 94% |
2,5-difluorobenzoyl chloride
ethyl 4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside
ethyl 4,6-O-benzylidene-2-O-(2,5-difluorobenzoyl)-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 44h; Inert atmosphere; | 94% |
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