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| CAS No.: | 3969-84-4 |
|---|---|
| Name: | 3,4-O-ISOPROPYLIDENE-D-MANNITOL |
| Molecular Structure: | |
|
|
|
| Formula: | C9H18O6 |
| Molecular Weight: | 222.238 |
| Synonyms: | Mannitol,3,4-O-isopropylidene- (6CI,7CI);Mannitol, 3,4-O-isopropylidene-, D- (8CI);3,4-Isopropylidene-D-mannitol;D-Mannitol3,4-acetonide;NSC 121512; |
| Density: | 1.304 g/cm3 |
| Melting Point: | 85-88 °C(lit.) |
| Boiling Point: | 438.8 °C at 760 mmHg |
| Flash Point: | 219.2 °C |
| Appearance: | White crystalline powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 20/21/22-36/37/38 |
| Safety: | 22-24/25-36-26 |
| PSA: | 99.38000 |
| LogP: | -1.78710 |
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- 852475-26-4MC1568
- 43224-75-52,2,6,6-Tetramethyl-4-(2-propyleneoxy) Piperidine
- 3969-59-3, 4239-88-7, 81704-51-0
(+)-1,2,3,4,5,6-tris-O-isopropylidene-D-mannitol
- 3969-84-4
3,4-di-O-isopropylidene-D-mannitol
- 3969-59-3
mannitol triacetonide
A
- 3969-84-4
3,4-di-O-isopropylidene-D-mannitol
B
- 38145-93-6
1,2:3,4-di-O-isopropylidene-D-mannitol
| Conditions | Yield |
|---|---|
| With H-Beta zeolite; water In methanol at 20℃; for 6h; Product distribution; Further Variations:; Reagents; reaction time; molar ratio; | A 36% B 48% |
| With hydrogenchloride In ethanol at 45℃; for 1h; | A 36 % Chromat. B 42 % Chromat. |
| With hydrogenchloride In ethanol at 45℃; for 1h; Product distribution; time; | A 36 % Chromat. B 42 % Chromat. |
| Conditions | Yield |
|---|---|
| Stage #1: mannitol; acetone With sulfuric acid at 20℃; for 48h; Stage #2: With acetic acid In water for 2h; Further stages.; | 38% |
| With sulfuric acid; acetic acid 1.) HOAc, 25 deg C, 20 h, 2.) 40 deg C, 1.75 h; Yield given. Multistep reaction; | |
| With sulfuric acid; acetic acid 1.) 23 deg C, 24 h, 2.) 40 deg C, 2 h; Multistep reaction; | |
| Stage #1: mannitol; acetone With sulfuric acid cyclocondensation; Stage #2: In water; acetic acid Hydrolysis; Further stages.; | |
| Stage #1: mannitol; acetone With sulfuric acid cyclocondensation; Stage #2: With acetic acid at 40℃; for 2.5h; Hydrolysis; Further stages.; |
- 3969-84-4
3,4-di-O-isopropylidene-D-mannitol
| Conditions | Yield |
|---|---|
| With ammonia at 20℃; |
- 7732-18-5
water
- 63700-05-0
1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol
- 3969-84-4
3,4-di-O-isopropylidene-D-mannitol
| Conditions | Yield |
|---|---|
| With sodium carbonate; sulfuric acid In acetone | |
| Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / acetone / 24 h / Reflux 2: hydrogenchloride / water; methanol / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: indium(III) triflate / 3 h / 65 °C 2: methanol / 2 h / 40 °C / Acidic conditions View Scheme | |
| Multi-step reaction with 2 steps 1: sulfuric acid / acetone 2: acetic acid / water / 1 h / 40 °C View Scheme |
- 18162-48-6
tert-butyldimethylsilyl chloride
- 3969-84-4
3,4-di-O-isopropylidene-D-mannitol
- 172995-87-8
1,6-bis(tert-butyldimethylsilyloxy)-3,4-di-O-isopropylidene-D-mannitol
| Conditions | Yield |
|---|---|
| With 1H-imidazole In dichloromethane at 0℃; for 2h; | 100% |
| With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; | 100% |
| With dmap; triethylamine In dichloromethane at 20℃; for 8h; | 94% |
| With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.25h; |
| Conditions | Yield |
|---|---|
| Stage #1: 3,4-di-O-isopropylidene-D-mannitol With 1H-imidazole; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h; Inert atmosphere; Stage #2: 1-bromomethyl-4-bromobenzene In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 24h; Inert atmosphere; | 100% |
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Chemistry
IUPAC Name: (1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol
Product Name: 3,4-O-Isopropylidene-d-mannitol
The MF of (1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol (CAS NO.3969-84-4) is C9H18O6.
The MW of (1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol (CAS NO.3969-84-4) is 222.24.
Synonyms of (1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol (CAS NO.3969-84-4): 3,4-Isopropylidene-D-mannitol ; 3,4-O-Isopropylidene-D-mannitol ; 3,4-Isopropylidene-D-mannitol , 98%
Product Categories: Biochemistry;Dioxanes & Dioxolanes;Dioxolanes;O-Substituted Sugars;Sugar Alcohols;Sugars;Naphthyridine,Quinoline;Carbohydrate Synthesis
Apperance: White crystalline powder
Index of Refraction: 1.509
Density: 1.303 g/ml
Flash Point: 219.2 °C
Boiling Point: 438.8 °C
Melting Point: 85-88 °C
Storage temp: Store at 0 °C
Uses
(1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol (CAS NO.3969-84-4) is used as Chemical reagents, organic intermediates, fine chemicals, pharmaceutical research and development.
Safety Profile
Safety information of (1S)-1-[(4R,5S)-5-[(1S)-1,2-Dihydroxyethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethane-1,2-diol (CAS NO.3969-84-4):
Hazard Codes 
Xn
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
22 Do not breathe dust
24/25 Avoid contact with skin and eyes
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
WGK Germany 3