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CAS No.: | 40391-99-9 |
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Name: | Pamidronic acid |
Article Data: | 32 |
Molecular Structure: | |
Formula: | C3H11NO7P2 |
Molecular Weight: | 279.034 |
Synonyms: | Phosphonicacid, (3-amino-1-hydroxypropylidene)bis- (9CI);(3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate;(3-Amino-1-hydroxypropylidene)bisphosphonic acid;(a-Hydroxy-g-aminopropylidene)diphosphonic acid;3-Amino-1-hydroxypropane-1,1-diphosphonic acid;3-Amino-1-hydroxypropylidene-1,1-bisphosphonic acid;3-Amino-1-hydroxypropylidenediphosphonic acid;Amidronic acid;Phosphonic acid,P,P'-(3-amino-1-hydroxypropylidene)bis-;Panolin;Propane-1-hydroxy-3-amino-1,1-diphosphonic acid; |
EINECS: | 254-905-2 |
Density: | 1.998 g/cm3 |
Melting Point: | 226-228 °C |
Boiling Point: | 658.7 °C at 760 mmHg |
Flash Point: | 352.2 °C |
Appearance: | COA |
PSA: | 180.93000 |
LogP: | -0.96300 |
3-amino propanoic acid
pamidronate
Conditions | Yield |
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With methanesulfonic acid; phosphorous acid; phosphorus trichloride at 65 - 70℃; Inert atmosphere; | 99% |
Stage #1: 3-amino propanoic acid With phosphorus trichloride In methanesulfonic acid at 80 - 85℃; Stage #2: With water In methanesulfonic acid at 105℃; for 4h; | 85% |
With phosphonic Acid; phosphorus trichloride In chlorobenzene at 100℃; for 3h; Inert atmosphere; | 82% |
[3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid
pamidronate
Conditions | Yield |
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With hydrogen; palladium on activated charcoal In methanol for 24h; | 90% |
[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-hydroxy-1-phosphonopropyl]phosphonic acid
pamidronate
Conditions | Yield |
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With hydrazine hydrate In water at 20℃; for 0.5h; | 67% |
With hydrogenchloride In water for 5.5h; Reflux; |
pamidronate
Conditions | Yield |
---|---|
With sodium methylate In ethanol | 99.6% |
With sodium methylate In methanol | 97.9% |
With sodium hydroxide In water |
pamidronate
water
Conditions | Yield |
---|---|
In water High Pressure; equimol., heatd at 70°C in a closed flask for for 3 wk; crysts. decanted, dried (air); elem. anal.; | 95% |
Conditions | Yield |
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With formic acid for 17h; Heating; | 92% |
6-maleimidohexanoic acid N-hydroxylsuccinimide ester
pamidronate
Conditions | Yield |
---|---|
With sodium hydroxide In water; acetone at 20℃; pH=8 - 9; | 88% |
pamidronate
Conditions | Yield |
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With sodium nitrite In Na2 -salt; water | 85% |
pamidronate
water
Conditions | Yield |
---|---|
With NaOH In water High Pressure; a mixt. of Cu-contg. compd. (0.5 mmol), ligand (0.5 mmol) and water adjusted to pH 4.2 with NaOH aq. soln. was sealed in a Teflon-lined autoclave and heated at 160°C for 3 d; slow cooling to room temp.; crystals were filtered off and washed with water; elem. anal.; | 85% |
4-chloroquinazoline
pamidronate
Conditions | Yield |
---|---|
Stage #1: 4-chloroquinazoline; pamidronate With potassium carbonate In water at 95℃; for 24h; Reflux; Stage #2: With hydrogenchloride In water at 5℃; for 24h; pH=1; | 82% |
IUPAC Name: (3-Amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
Molecular Formula: C3H11NO7P2
Molecular Weight: 235.07 g/mol
Canonical SMILES: C(P(O)(O)=O)(P(O)(O)=O)(CCN)O
InChI: InChI=1/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
EINECS: 254-905-2
Classification Code: Bone Density Conservation Agents; Bone resorption inhibitor
Product Categories: (intermediate of pamidronate disodium); Delavirdine
Density: 1.998 g/cm3
Flash Point: 352.2 °C
Enthalpy of Vaporization: 111 kJ/mol
Boiling Point: 658.7 °C at 760 mmHg
Melting Point: 226-228 °C
Vapour Pressure of Pamidronic acid (CAS NO.40391-99-9): 3.79E-20 mmHg at 25 °C
Pamidronic acid (CAS NO.40391-99-9) is used to prevent bone loss, and treat osteoporosis. It is also used to strengthen bone in Paget's disease, to prevent bone loss due to steroid use, and in certain cancers with high propensity to bone, such as multiple myeloma. It is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta, or brittle bones.
Pamidronic acid (CAS NO.40391-99-9), its Synonyms are Amidronate ; Acide pamidronique ; Acido pamidronico ; Pamidronate ; (3-Amino-1-hydroxypropylidene)bisphosphonic acid ; (3-Amino-1-hydroxypropylidene)diphosphonic acid .