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446-72-0

Basic Information
CAS No.: 446-72-0
Name: Genistein
Molecular Structure:
Molecular Structure of 446-72-0 (Genistein)
Formula: C15H10O5
Molecular Weight: 270.23
Synonyms: 4H-1-Benzopyran-4-one, 5, 7-dihydroxy-3- (4-hydroxyphenyl)-;5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one;Prunetol;Isoflavone, 4,5,7-trihydroxy-;4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-;SIPI 807-1;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone;5-18-04-00594 (Beilstein Handbook Reference);C.I. 75610;NPI 031L;4,5,7-Trihydroxyisoflavone;4',5,7-trihydroxyisoflavone;4,5, 7-Trihydroxyisoflavone;Genisteol;Baichanin A;Differenol A;4H-1-Benzopyran-4-one,5,7-dihydroxy-3- (4-hydroxyphenyl)-;Genisterin;Sophoricol;5,7,4-Trihydroxyisoflavone;Genistein 4,5,7-Trihydroxyisoflavone;
EINECS: 207-174-9
Density: 1.548 g/cm3
Melting Point: 297-298 °C
Boiling Point: 555.5 °C at 760 mmHg
Flash Point: 217.1 °C
Solubility: insoluble in water
Appearance: Yellow crystalline solid
Hazard Symbols: IrritantXi
Risk Codes: 36/38
Safety: 26-24/25-22
Transport Information:
PSA: 90.90000
LogP: 2.57680
Synthetic route
529-59-9

genistin

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;100%
In hydrogenchloride99%
β-glucosidase, derived from almond In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;11.8%
73566-30-0

genistein-7-O-β-D-(6''-O-acetylglucopyranoside)

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
diglycosidase, produced by Penicillium multicolor IAM7153 In methanol at 55℃; for 3h; pH=4; Enzyme kinetics; Aqueous acetate buffer;99.9%
diglycosidase, produced by Aspergillus fumigatus IAM2046 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;35.2%
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;6.2%
β-xylosidase, derived from pectinase G In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;0.5%

sulfur trioxide N,N-dimethylformamide complex

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin With sodium carbonate In N,N-dimethyl-formamide at 25℃; for 3h;
Stage #2: sulfur trioxide N,N-dimethylformamide complex In N,N-dimethyl-formamide at 0 - 80℃; for 18.5h;
Stage #3: With sulfuric acid; water In N,N-dimethyl-formamide for 0.666667h; Product distribution / selectivity;
95%
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

141-53-7

sodium formate

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate With propionyl chloride In acetone at 21 - 32℃; for 1h;
Stage #2: With triethylamine In acetone at 20 - 32℃; for 2.5h;
Stage #3: With sulfuric acid; water In acetone at 20℃; for 16h; Product distribution / selectivity;
94.8%
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate With acetyl chloride In acetone at 12 - 25℃; for 2h;
Stage #2: With triethylamine In acetone at 18 - 32℃; for 3h;
Stage #3: With sulfuric acid; water In acetone at 20℃; for 16h; Product distribution / selectivity;
91.7%
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate With isobutyryl chloride In acetone at 21 - 32℃; for 2h;
Stage #2: With triethylamine In acetone at 18 - 32℃; for 2.5h;
Stage #3: With sulfuric acid; water In acetone at 20℃; for 16h; Product distribution / selectivity;
90.2%
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

141-53-7

sodium formate

79-03-8

propionyl chloride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: sodium formate; propionyl chloride In acetone at 21 - 35℃; for 3h;
Stage #2: 2,4,4',6-tetrahydroxydeoxybenzoin With triethylamine In acetone at 20 - 22℃; for 2h;
Stage #3: With sulfuric acid; water In acetone at 20℃; for 16h;
93%
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate; propionyl chloride In acetone at 21 - 35℃; for 2h;
Stage #2: With triethylamine In acetone at 18 - 35℃; for 3h;
Stage #3: With sulfuric acid; water In acetone at 60 - 70℃; for 1.5h;
92.2%
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate; propionyl chloride In formic acid ethyl ester at 23 - 35℃; for 3h;
Stage #2: With triethylamine In formic acid ethyl ester at 18 - 22℃; for 16h;
Stage #3: With sulfuric acid; water In formic acid ethyl ester at 80℃;
92.7%
1236208-91-5

3-(4-hydroxyphenyl)-5,7-bis(methoxymethoxy)-4H-1-benzopyran-4-one

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogenchloride; water In methanol; chloroform for 1h; Reflux;92%
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

141-53-7

sodium formate

79-30-1

isobutyryl chloride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; sodium formate; isobutyryl chloride In acetone at 21 - 32℃; for 3h;
Stage #2: With triethylamine In acetone at 18 - 32℃; for 2h;
Stage #3: With sulfuric acid; water In acetone at 60 - 70℃; for 3h;
90.3%
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; methanesulfonyl chloride In N,N-dimethyl-formamide at 50℃; for 12h; Molecular sieve;90%
With methanesulfonyl chloride In N,N-dimethyl-formamide at 60 - 70℃; for 1h;53%
Multi-step reaction with 2 steps
1: pyridine / Behandeln des Reaktionsprodukts mit wss. Natronlauge
2: 325 °C
View Scheme
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

68-12-2, 33513-42-7

N,N-dimethyl-formamide

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With phosphorus pentachloride at 55℃; for 0.333333h; Chlorination;
Stage #2: 2,4,4',6-tetrahydroxydeoxybenzoin With boron trifluoride diethyl etherate In N,N-dimethyl-formamide at 20℃; for 1h; Cycloaddition;
90%
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin With boron trifluoride diethyl etherate In N,N-dimethyl-formamide at 50 - 60℃; Cooling with ice;
Stage #2: N,N-dimethyl-formamide With methanesulfonyl chloride at 50 - 70℃;
84%
With boron trifluoride diethyl etherate; methanesulfonyl chloride 1.) irradiation, reflux, 15 s, 2.) irradiation, reflux, 1 min; Yield given. Multistep reaction;
With phosphorus pentachloride; boron trifluoride diethyl etherate at 20℃; for 1h; Cyclization;
With boron trifluoride diethyl etherate; methanesulfonyl chloride at 50 - 100℃;

[5-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-7-yl]dihydrogen phosphate

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With sulfatase VIII In water at 37℃; for 0.5h; pH=5.2;89%
64-18-6

formic acid

15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

123-62-6

propionic acid anhydride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: formic acid; propionic acid anhydride at 25 - 45℃; for 2h;
Stage #2: 2,4,4',6-tetrahydroxydeoxybenzoin With triethylamine In acetone at 20 - 40℃; for 19h;
Stage #3: With sulfuric acid; water In acetone at 60℃;
86.5%
Stage #1: formic acid; 2,4,4',6-tetrahydroxydeoxybenzoin; propionic acid anhydride at 25 - 45℃; for 2h;
Stage #2: With triethylamine at 20 - 40℃; for 19h;
Stage #3: With sulfuric acid; water at 75℃; for 2.5h;
82.5%
491-80-5

5,7-Dihydroxy-3-(4-methoxy-phenyl)-chromen-4-on

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With aluminum (III) chloride In toluene at 140℃; for 6h;84%
With aluminium trichloride In benzene for 18h; Heating;47%
With hydrogen iodide
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

10500-31-9

Propionic formic anhydride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: 2,4,4',6-tetrahydroxydeoxybenzoin; Propionic formic anhydride With triethylamine In acetone at 25 - 40℃; for 3h;
Stage #2: With sulfuric acid; water In acetone at 20 - 60℃;
84%
51011-05-3

6''-O-malonylgenistin

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
diglycosidase, produced by Penicillium multicolor IAM7153 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;82.3%
β-glucosidase, derived from Aspergillus niger In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;12.1%
diglycosidase, produced by Aspergillus fumigatus IAM2046 In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;8.2%
β-xylosidase, derived from pectinase G In methanol at 55℃; for 6h; pH=4; Enzyme kinetics; Aqueous acetate buffer;2%
With Dalbergia nigrescens β-glucosidase In acetate buffer; dimethyl sulfoxide at 37℃; for 0.166667h; pH=5.5; Enzyme kinetics; Further Variations:; Reagents;
64-18-6

formic acid

15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: formic acid; 2,4,4',6-tetrahydroxydeoxybenzoin With acetic anhydride; triethylamine at 20℃; for 24h; Industrial scale;
Stage #2: With hydrogenchloride; water In methanol at 20℃; for 22h; Industrial scale;
79.5%
290-87-9

1,3,5-Triazine

15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; acetic anhydride In diethyl ether; acetic acid Heating;78%
2491-38-5

2-bromo-1-(4'-hydroxyphenyl)-1-ethanone

487-70-7

2,4,6-trihydroxybenzaldehyde

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone With thiamine hydrochloride In ethanol at 20℃; for 0.25h; Green chemistry;
Stage #2: 2,4,6-trihydroxybenzaldehyde In ethanol at 20℃; for 1.58333h; Green chemistry;
75%
15485-65-1

2,4,4',6-tetrahydroxydeoxybenzoin

141-53-7

sodium formate

98-88-4

benzoyl chloride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
Stage #1: sodium formate; benzoyl chloride In acetone at 21 - 40℃; for 3h;
Stage #2: 2,4,4',6-tetrahydroxydeoxybenzoin With triethylamine In acetone at 21 - 35℃; for 3h;
Stage #3: With sulfuric acid; water In acetone at 20℃; for 16h;
52.7%
22151-32-2

5,7-dihydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
at 325℃;
78694-77-6

7-((2S,3R,4R)-3,4-Dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-3-[4-((2R,3S,4S)-3,4-dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-phenyl]-5-hydroxy-chromen-4-one

B

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With sulfuric acid Heating;
128508-06-5

5-O-β-D-glucopyranosylgenistein

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With malic acid at 60℃; other object of study: half-lives; other reagent : acetic acid, oxalic acid, HCl; other temperature;
66026-80-0

4′,7-dihydroxy-8β-D-glucose isoflavone

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogen iodide; phenol at 135℃; for 7h; Heating;25 mg
32361-88-9

6,8-di-C-β-D-glucopyranosyl-4',5,7-trihydroxyisoflavone

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogen iodide; phenol Heating;20 mg
148356-61-0

1-(2-acetoxy-4,6-dihydroxyphenyl)-3,3-dimethoxy-2-(4-hydroxyphenyl)propan-1-one

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating; Yield given;

genistein 7-O-(2"-p-coumaroyl-β-D-glucopyranoside)

A

2280-44-6

D-Glucose

B

7400-08-0

p-Coumaric Acid

C

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogenchloride In methanol Heating;
152-95-4

sophoricoside

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With water Hydrolysis; Acid hydrolysis;
5.7.4'-trimethoxy-isoflavone

5.7.4'-trimethoxy-isoflavone

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogen iodide; acetic anhydride; acetic acid
genisteine-7-methyl ether

genisteine-7-methyl ether

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

Conditions
ConditionsYield
With hydrogen iodide at 130℃;
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

98-09-9

benzenesulfonyl chloride

1041727-57-4

3-(4-benzenesulfonyloxyphenyl)-5,7-bis(benzenesulfonyloxy)-4H-chromen-4-one

Conditions
ConditionsYield
With pyridine at -20℃; for 3h; Inert atmosphere;99%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

814-68-6

acryloyl chloride

C21H14O7

Conditions
ConditionsYield
With triethylamine In acetone at 20℃; for 24h;98.6%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

108-24-7

acetic anhydride

5995-97-1

4',5,7-Triacetoxyisoflavone

Conditions
ConditionsYield
With pyridine Reflux;98%
With pyridine at 70℃; for 6h;96%
With pyridine In chloroform at 20℃; for 8h; Inert atmosphere;93%
for 6h; Heating;53%
Acetylation;
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

112-76-5

Stearoyl chloride

genistein-4',7-distearate

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 30℃; for 2.5h; Etherification;96%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

7,5,4’-trihydroxy-3’-nitroisoflavone

Conditions
ConditionsYield
With ammonium nitrate; trifluoroacetic anhydride In acetonitrile at 20℃; for 1.5h;96%
112-77-6

(Z)-9-octadecenoyl chloride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

genistein-4',7-dioleate

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 30℃; for 2.5h; Etherification;95%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

74-88-4

methyl iodide

1162-82-9

4',5,7-trimethoxyisoflavone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 4h;95%
With potassium carbonate In acetone at 60℃;95%
With potassium carbonate In acetone at 50℃; for 3h; sonication;85%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

2106-10-7

1-deoxy-1-fluoro-α-D-glucose

genistein 7-α-O-glucoside

Conditions
ConditionsYield
With α-glucosidase from sulfolobus solfataricus In dimethyl sulfoxide at 45℃; for 2h; pH=9; Enzymatic reaction;95%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

108-24-7

acetic anhydride

65388-04-7

4-(7-acetoxy-5-hydroxy-4-oxo-4H-chromen-3-yl)phenyl acetate

Conditions
ConditionsYield
In pyridine at 20℃; for 24h;92%
In pyridine at 20℃; for 24h;92%
With pyridine at 20℃; for 24h;92%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

142-61-0

Hexanoyl chloride

918158-57-3

5,7,4'-tri-O-hexanoyl-genistein

Conditions
ConditionsYield
With pyridine; dmap91%
With pyridine; dmap In chloroform at 20℃; for 9h; Inert atmosphere;91%
With dmap; triethylamine In N,N-dimethyl-formamide at 20℃; for 4.5h; Cooling with ice;81%
With pyridine at 0 - 20℃; for 18h;
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

A

21554-71-2

dihydrogenistein

124093-22-7

(3S,4R)-3-(4-Hydroxy-phenyl)-chroman-4,5,7-triol

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In methanol Ambient temperature;A 90%
B n/a
With ammonium formate; palladium on activated charcoal In methanol for 2h; Heating;A 59%
B 21%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

109-64-8

1,3-dibromo-propane

862255-04-7

4',5,7-tri(3-bromopropoxy)isoflavone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1.5h; sonication;90%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 4.75h;
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

98-09-9

benzenesulfonyl chloride

1041727-51-8

3-(4-hydroxyphenyl)-7-benzenesulfonyloxy-5-hydroxy-4H-chromen-4-one

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at -20℃; for 0.333333h; Inert atmosphere;90%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

2052-49-5

tetra(n-butyl)ammonium hydroxide

tetra n-butylammonium salt of genistein

Conditions
ConditionsYield
In methanol; water at 20℃;89%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

106-93-4

ethylene dibromide

862255-00-3

7-(2-bromoethoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide sonication;88%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1.5h; sonication;86%
With sodium hydrogencarbonate In acetone at 65℃; for 24h;71%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

108-24-7

acetic anhydride

A

65388-04-7

4-(7-acetoxy-5-hydroxy-4-oxo-4H-chromen-3-yl)phenyl acetate

B

7-acetoxy-4',5-dihydroxygenistein

Conditions
ConditionsYield
With pyridine for 7h; Reflux;A 87.2%
B 5.3%
112-77-6

(Z)-9-octadecenoyl chloride

446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

genistein-7-monooleate

Conditions
ConditionsYield
With potassium tert-butylate In N,N-dimethyl-formamide at 30℃; for 2.5h; Etherification;87%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

109-64-8

1,3-dibromo-propane

862255-02-5

7-(3-bromopropoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide sonication;87%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1.5h; sonication;85%
With sodium hydrogencarbonate; potassium carbonate In acetone at 65℃; for 8h;78.47%
446-72-0

5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on

107-30-2

chloromethyl methyl ether

5,7,4'-trimethoxymethoxyisoflavone

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 2h;87%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 2h;87%
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  • Genistein

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    446-72-0

    MSDS/COA Download

    Genistein

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  • Genistein

  • Casno:

    446-72-0

    MSDS/COA Download

    Genistein

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 320.15-320.15/Kilogram

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  • E-0005   Genistein

  • Casno:

    446-72-0

    E-0005 Genistein

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    The quality is guaranteed. If you find the product is wrong compared with COA, we promise 100% refund or change product. COA and HPLC will be shipped out with goods. You can also inform your analysis method and we will follow your analysi

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  •  shanghai Tauto Biotech Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-21-51320588 ext. 8025

    Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA

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  • Casno:

    446-72-0

    Genistein

    Min.Order: 0

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    Cartoon Ingredients Co.,Ltd.is located in NanJing, the capital of Jiangsu Province.with Convenient traffic As a manufacturer, the company mainly engaged in providing Food ingredients, Herbal extracts, Vitamins, APIs and Fine chemicals &a

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-25-58074918

    Address:Room 2109, RuiHua Business Center,315 South ZhongShan Road, Nanjing 210001, China

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  • Casno:

    446-72-0

    98% Genistein CAS:446-72-0

    Min.Order: 1 Kilogram

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    Genistein Product name: Genistein Specification: 98% Appearance: White powder Part Used: Flower Extract Solution: Grain alcohol CAS No: 446-72-0 Introduction Genista is a genus of flowering plants in the legume family Fabac

    Greenutra Resource is committed to the natural ingredients, formulation and application in the field of R&D, production and sales as the “one-step” natural product solution provide

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0086-411-39553357

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    446-72-0

    Genistein Manufacturer/High quality/Best price/In stock

    Min.Order: 1 Kilogram

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    As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

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  • Casno:

    446-72-0

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    Min.Order: 0 Metric Ton

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    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional

  •  Simagchem Corporation

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-592-2680277

    Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

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    446-72-0

    MSDS/COA Download

    Genistein CAS:446-72-0 Safe delivery Free of customs clearance

    Min.Order: 1 Kilogram

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    What's our company advantages 1. Government support guarantees good company credibility and finance safe. 2. Finer chem is confident at the quality of the products, and would like to supply free sample to our customers. 3. Factory locates in n

    Mulei (Wuhan) New Material Technology Co. Ltd is a scientific and technological company integrating product research and development, manufacture and trading of chemical intermedia

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619831967063

    Address:Office1201#, Block C, Hanjie Headquarters International Plaza, Zhongbei Rd, Wuchang District, Wuhan

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  • Genistein

  • Casno:

    446-72-0

    MSDS/COA Download

    Genistein

    Min.Order: 100 Gram

    FOB Price:  USD $ 2.0-2.0/Gram

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    Business Type:Manufacturers

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    446-72-0

    GMP factory supply high quality Genistein

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    Functions 1.Be used as antioxidant . 2.Inhibition of angiogenesis, and tyrosine kinases, 3.Antioxidant and anti-estrogen action . 4.Genistein powder is also used to ease menopause symptoms, such as hot flushes. Certifications H

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    Business Type:Trading Company

    Tel:+86-551-65418695

    Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China

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    446-72-0

    Supply Natural genista extract genistein with quick delivery time

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    1.genistein products,genista extract genistein 2.High quality,competitive price 3.Manufacture genistein products 4.Promptly Appearance:White Powder Package:25Kg/drum Port:Shanghai, Ningbo, Tianjin, Qingdao

    Orchid Chemical was established in 2009; we are headquartered in Hangzhou, which is 200 km from China's biggest sea port, Shanghai. Orchid chemical is a joint-venture company, com

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-85395792

    Address:607, North Zhongshan Road, Hangzhou 310000 China

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  • Supply 99% CAS 446-72-0 Genistein Powder

  • Casno:

    446-72-0

    MSDS/COA Download

    Supply 99% CAS 446-72-0 Genistein Powder

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 430.0-470.0/Kilogram

    1. Who are we We are based in Shaanxi, China, start from 2018,sell to North America(00.00%), Western Europe(00.00%),South America(00.00%),Southeast Asia(00.00%), Eastern Europe(00.00%). There are total about 11-50 people in our office. 2. How can

    Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of S

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    Business Type:Trading Company

    Tel:+008618049624045

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  • Thermopsis lanceolate Extract 98% Genistein Powder with Water soluble Cas:446-72-0

  • Casno:

    446-72-0

    Thermopsis lanceolate Extract 98% Genistein Powder with Water soluble Cas:446-72-0

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 399.0-405.0/Kilogram

    Come From Nature / Building Healthy Life Beauty In Your Face / Nourishment Your Taste Bud. Professional Factory: We has a complete production and operating system, with an annual output capacity of 2000 tons. It can produce variety of con

    Xi 'an Quanao Biotech Co., Ltd. with 10 years experience in plant extract filed. Focus on the research, production and sale of Plant and Animal extract ,Medical intermediate ,compl

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-29-86719484

    Address:B-1604,Juncheng Guoji, Taiyuan Road, Weiyang distirct

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  • Casno:

    446-72-0

    Genistein

    Min.Order: 10 Milligram

    FOB Price:  USD $ 0.0-0.0/Milligram

    1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • Casno:

    446-72-0

    Factory supply high quality Genistein 446-72-0

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Factory supply high quality Genistein 446-72-0 TAIHO Unique Advantages: 1.We're factory 2.Free samples available 3.Commodity inspection can be done 4.ISO9001,Kosher certifications 5.10 years experiences Appearance:powder Storage:Store in cool &d

    As a member of TAIHO Group,Hubei Taiho Chemical Co.,Ltd,is a professional new-type chemicals enterprise combined into research and development,production and sales.We adhere to the

  •  Hubei Taiho Chemical Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-18120399543

    Address:No. 49 taifeng Road,Qianjiang City,Hubei,China

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  • Genistein (C.I. 75610)

  • Casno:

    446-72-0

    Genistein (C.I. 75610)

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aro

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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  • Genistein    CAS: 446-72-0

  • Casno:

    446-72-0

    Genistein CAS: 446-72-0

    Min.Order: 5 Metric Ton

    FOB Price:  USD $ 1.0-2.0/Metric Ton

    Product Name: Genistein Appearance: Light Yellow Powder Cas. No.: 446-72-0 EINECS No.: 207-174-9 Molecular Formula: C15H10O5 Molecular Weight: 270.24 Specification: 99% Appearance:Yellow Crystalline Solid Storage:Store in cool and dry place,

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

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  • Casno:

    446-72-0

    TIANFU-CHEM Genistein

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

    Our advantage:Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scient

    Our company engages in Electronic chemicals such as OLED,Photoresist chemical,Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • Casno:

    446-72-0

    Wholesale price CAS 446-72-0 with fast shipping

    Min.Order: 10 Gram

    FOB Price:  USD $ 146.0-176.0/Gram

    WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is (Wen Xi Pharma), including three subs

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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    446-72-0

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    BLOOM TECH Advanced API/Technology support Genistein CAS 446-72-0

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Inquiry guide 1.Please send the quantity(Weight) to us, we will arrange our sales to provide the one-for-one service for you. 2.Then we will provide the professional quotation list for you, it will be including all the factors in who

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  •  Shaanxi BLOOM TECH Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-29-86470566

    Address:Block A of Central Mansion, No.113 of Weiyang Rd, ETDZ, Xi'an, Shaanxi 710016, China

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    446-72-0

    Genistein/ LIDE PHARMA- Factory supply / Best price

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    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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  • Casno:

    446-72-0

    Genistein

    Min.Order: 0 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    DESCRIPTION Genistein is a phytoestrogen and belongs to the category of isoflavones.Genistein was first isolated in 1899 from the dyer's broom, Genista tinctoria;hence, the chemical name derived from the generic name. The compound nucleusw

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    Business Type:Trading Company

    Tel:86-517-88279580

    Address:INDUSTRIAL ZONE,XUYI COUNTY,JIANGSU PROVINCE CHINA

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  • Casno:

    446-72-0

    Genistein

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    Wuhan Fortuna Chemical Co., Ltd, located in the predominant Wu Han City where is a traffic hinge of China, is a big integrative chemical enterprise being engaged in producing and

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-27-59207850

    Address:A2705,Dong Yi Shi Qu,129# XinHua Road,WuHan,China

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    446-72-0

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

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    446-72-0

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    Business Type:Trading Company

    Tel:+86-18871490254

    Address:High-tech Industrial Park,Tianmen city,Hubei province.

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    446-72-0

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    446-72-0

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    Business Type:Trading Company

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    446-72-0

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    Min.Order: 10 Gram

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    China (Mainland)  |  Contact Details

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    446-72-0

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

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    Address:Weiyang District

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    446-72-0

    MSDS/COA Download

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    Product Name: Genistein Synonyms: 4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619930503256

    Address:No.66, Yuhua West Road

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    446-72-0

    Genistein

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-28-85370565

    Address:No.8 Wuke West Second Road, Wuhou

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    446-72-0

    Genistein 446-72-0 Large in promotion

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    Genistein Basic information Product Name: Genistein Synonyms: 4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol CAS: 446-72-0 MF: C

    SHANGHAI MINSTAR CHEMICAL CO., LTD. is a leading, experienced, professional supplier of API & intermediates, plant extract, food additive, fine chemicals and industry chemicals, et

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-18019205509

    Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA

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  • Casno:

    446-72-0

    MSDS/COA Download

    Genistein

    Min.Order: 10 Gram

    FOB Price:  USD $ 7.0-9.0/Gram

    0 Risk High quality High service We, Jilin Tely Imp & Exp Co., Ltd. mainly supply and export products including: pharmaceutical raw materials,Chemical reagents, Food additives, pharmaceutical and pesticide intermediates. We have succes

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-431-81915458

    Address:Room 302, 47 Changping Street, Chaoyang District, Changchun, Jilin Province,China

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  • High quality Genistein supplier in China CAS NO.446-72-0

  • Casno:

    446-72-0

    High quality Genistein supplier in China CAS NO.446-72-0

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 0.0-0.0/Kilogram

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  • Genistein

  • Casno:

    446-72-0

    Genistein

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

    Shanghai BetterBioChem Co., Ltd. specializes in research, production of APIs, building blocks and key pharmaceutical intermediates. We provide our products from milligrams to kilog

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    Business Type:Lab/Research institutions

    Tel:+86-18013506594

    Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China

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Chemistry

Molecular Structure of Genistein (CAS NO.446-72-0):

IUPAC Name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one 
Empirical Formula: C15H10O5
Molecular Weight: 270.2369
H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 86.99 Å2
Index of Refraction: 1.732
Molar Refractivity: 69.85 cm3
Molar Volume: 174.5 cm3
Surface Tension: 79.5 dyne/cm
Density: 1.548 g/cm3
Flash Point: 217.1 °C
Enthalpy of Vaporization: 86.81 kJ/mol
Boiling Point: 555.5 °C at 760 mmHg
Vapour Pressure: 6E-13 mmHg at 25°C
Melting point: 297-298 °C
Storage temp: −20°C
Water Solubility: insoluble
Merck: 14,4391
BRN: 263823
InChI
InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
Smiles
c12c(c(c(c3ccc(O)cc3)co1)=O)c(cc(c2)O)O
EINECS: 207-174-9
Product Categories: pharmacetical; Biochemistry; Flavonoids; Natural Plant Extract; The group of Daidzin; Inhibitors; Tyrosine Kinase Inhibitors; Protein Kinase; Signalling
Synonyms: 4H-1-Benzopyran-4-one, 5, 7-dihydroxy-3- (4-hydroxyphenyl)- ; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one ; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one ; Isoflavone, 4,5,7-trihydroxy- ; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone ; 5-18-04-00594 (Beilstein Handbook Reference) ; 4,5,7-Trihydroxyisoflavone

Uses

  Genistein (CAS NO.446-72-0) exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intraperitoneal > 500mg/kg (500mg/kg)   Journal of Antibiotics. Vol. 39, Pg. 606, 1986.

Consensus Reports

  Genistein (CAS NO.446-72-0) is reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/38
R36/38:Irritating to eyes and skin.
Safety Statements: 26-24/25-22
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S24/25:Avoid contact with skin and eyes. 
S22:Do not breathe dust.
WGK Germany: 3
RTECS: NR2392000

Specification

 Biological effects of Genistein (CAS NO.446-72-0) are some isoflavones act as antioxidants to counteract damaging effects of free radicals in tissues; Genistein protects against pro-inflammatory factor-induced vascular endothelial barrier dysfunction and inhibits leukocyte-endothelium interaction, thereby modulating vascular inflammation, a major event in the pathogenesis of atherosclerosis and it makes some cells more sensitive to radio-therapy.

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