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| CAS No.: | 4858-85-9 |
|---|---|
| Name: | 2,3-Dichloropyrazine |
| Molecular Structure: | |
|
|
|
| Formula: | C4H2Cl2N2 |
| Molecular Weight: | 148.979 |
| Synonyms: | Pyrazine,2,3-dichloro-; |
| EINECS: | 225-460-1 |
| Density: | 1.493 g/cm3 |
| Melting Point: | 22.5-24.5 °C |
| Boiling Point: | 190.6 °C at 760 mmHg |
| Flash Point: | 86.1 °C |
| Appearance: | clear colorless to light yellow liquid |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 36/37/38-20/21/22 |
| Safety: | 36/37/39-26-36 |
| PSA: | 25.78000 |
| LogP: | 1.78340 |
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- 14508-49-7
2-chloropyrazin
- 4858-85-9
2,3-dichloropyrazine
| Conditions | Yield |
|---|---|
| Stage #1: 2-chloropyrazin With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: With hexachloroethane In tetrahydrofuran; hexane at -78℃; for 1h; | 90% |
| With sulfuryl dichloride In N,N-dimethyl-formamide | 81% |
| Conditions | Yield |
|---|---|
| With trichlorophosphate | 84% |
- 6863-76-9
3-chloropyrazine 1-oxide
A
- 19745-07-4
2,5-dichloropyrazine
B
- 4858-85-9
2,3-dichloropyrazine
C
- 4774-14-5
2,6-dichloropyrazine
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given; | |
| With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given; |
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 6863-76-9
3-chloropyrazine 1-oxide
A
- 14508-49-7
2-chloropyrazin
B
- 19745-07-4
2,5-dichloropyrazine
C
- 4858-85-9
2,3-dichloropyrazine
D
- 4774-14-5
2,6-dichloropyrazine
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 16025-16-4
2-chloropyrazine 1-oxide
A
- 14508-49-7
2-chloropyrazin
B
- 4858-85-9
2,3-dichloropyrazine
C
- 4774-14-5
2,6-dichloropyrazine
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 14508-49-7
2-chloropyrazin
A
- 4858-85-9
2,3-dichloropyrazine
| Conditions | Yield |
|---|---|
| With chlorine at 475℃; |
- 290-37-9
1,4-pyrazine
- 7732-18-5
water
- 7782-50-5
chlorine
A
- 14508-49-7
2-chloropyrazin
B
- 19745-07-4
2,5-dichloropyrazine
C
- 4858-85-9
2,3-dichloropyrazine
D
- 4774-14-5
2,6-dichloropyrazine
| Conditions | Yield |
|---|---|
| at 350℃; Product distribution; |
| Conditions | Yield |
|---|---|
| With water; chlorine at 350℃; | |
| With water; chlorine at 400 - 500℃; | |
| With water; chlorine at 400 - 500℃; |
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 60℃; for 1h; Heating / reflux; |
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Chemistry
Molecular structure of 2,3-Dichloropyrazine (CAS NO.4858-85-9) is:
Product Name: 2,3-Dichloropyrazine
CAS Registry Number: 4858-85-9
IUPAC Name: 2,3-dichloropyrazine
Molecular Weight: 148.97808 [g/mol]
Molecular Formula: C4H2Cl2N2
XLogP3-AA: 1.7
H-Bond Donor: 0
H-Bond Acceptor: 2
EINECS: 225-460-1
Melting point: 22.5-24.5 °C
Surface Tension: 51.5 dyne/cm
Density: 1.493 g/cm3
Flash Point: 86.1 °C
Enthalpy of Vaporization: 40.93 kJ/mol
Boiling Point: 190.6 °C at 760 mmHg
Vapour Pressure: 0.745 mmHg at 25°C
Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Piperazine series;API intermediates;Pyrazines;Chloropyrazines, etc.;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrazinesHeterocyclic Building Blocks
Uses
2,3-Dichloropyrazine (CAS NO.4858-85-9) is used for pharmaceutical intermediates.
Safety Profile
Safty information about 2,3-Dichloropyrazine (CAS NO.4858-85-9) is:
Hazard Codes: 
Xn,Xi
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37/39-26-36
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Hazard Note: Irritant
HazardClass: IRRITANT
Specification
2,3-Dichloropyrazine (CAS NO.4858-85-9) is a clear colorless to light yellow liquid.