CAS No.486-25-9,9-Fluorenone Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	486-25-9
Name:	9-Fluorenone
Article Data:	709

Formula:	C₁₃H₈O
Molecular Weight:	180.206
Synonyms:	Fluoren-9-one(8CI);Fluorenone;NSC 5181;
EINECS:	207-630-7
Density:	1.244 g/cm³
Melting Point:	80-83 °C(lit.)
Boiling Point:	341.499 °C at 760 mmHg
Flash Point:	144.142 °C
Solubility:	insoluble in water
Appearance:	yellow flakes, chips or crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	24/25-36/37/39-27-26
PSA:	17.07000
LogP:	2.89800

Synthetic route

: 467-69-6
9-hydroxy-9-fluorene carboxylic acid

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With sodium perborate In acetic acid for 1.5h; steam bath;	100%
With (NMe4)2H2OCH3CN (L = ortho-phenylenebis(N'-methyloxamidate)); oxygen; pivalaldehyde In acetonitrile for 2h; Ambient temperature;	98%
With thionyl chloride for 2h; Heating;	91%

: 86-73-7
9H-fluorene

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With aluminum oxide; potassium permanganate In 1,2-dichloro-ethane for 118h; Product distribution; Ambient temperature; other reagent, reaction time;	100%
With potassium hydroxide; 18-crown-6 ether; oxygen In 1,2-dimethoxyethane at 20℃; for 1h;	100%
With aluminum oxide; potassium permanganate; water In 1,2-dichloro-ethane for 118h; Ambient temperature;	100%

: 1689-64-1
9-Fluorenol

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With potassium carbonate; chlorobenzene In toluene at 105℃; for 12h;	100%
With potassium osmate(VI) dihydrate; potassium carbonate; potassium hexacyanoferrate(III) In water; acetonitrile at 60℃; for 0.5h; chemoselective reaction;	100%
With chromium(VI) oxide; methyl-tridecylammonium chloride; sodium perborate In water; benzene at 60℃; for 24h;	99%

: 67-56-1
methanol

: 75997-04-5
4',4'-dimethyl-3'-phenylfluorene-9-spiro-2'-oxazolidin-5'-one

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With sulfuric acid for 8h; Heating; other characteristic reaction (with hydroxylamine);	100%

: 7049-31-2
9-fluorenone thioketal

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With trichloroisocyanuric acid; silver nitrate In water; acetonitrile Ambient temperature;	100%
With hydrogenchloride; dihydrogen peroxide In methanol Ambient temperature;	98%
With t-butyl bromide; dimethyl sulfoxide at 70 - 75℃; for 24h;	95%

: 751-35-9
9-fluorenone triphenylphosphazine

A: 486-25-9
9-fluorenone

B: 791-28-6
Triphenylphosphine oxide

Conditions

Conditions	Yield
With oxygen; methylene blue In dichloromethane at -78℃; for 0.0833333h; Irradiation; other reagent;	A 100% B n/a
With oxygen; methylene blue In dichloromethane Quantum yield; Irradiation;

: 88362-97-4
fluoren-9-one-dibenzyldithioacetal

A: 150-60-7
dibenzyl disulphide

B: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With tert-butylhypochlorite In tetrachloromethane for 1h; Ambient temperature; other reagent;	A n/a B 100%

: 2052-07-5
2-Bromobiphenyl

: 201230-82-2
carbon monoxide

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With cesium pivalate; palladium(0)bis(tricyclohexylphosphine) In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 7h; Carbonylation; cyclization;	100%
With tristricyclohexylphosphine palladium(0); cesium pivalate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 7h;	100%
With palladium diacetate; sodium carbonate; magnesium sulfate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid In toluene at 110℃; under 760.051 Torr; for 25h; Sealed tube; Inert atmosphere;	86%

: 201230-82-2
carbon monoxide

: 2113-51-1
2-iodobiphenyl

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With cesium pivalate; palladium(0)bis(tricyclohexylphosphine) In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 7h; Carbonylation; cyclization;	100%
With tristricyclohexylphosphine palladium(0); cesium pivalate In N,N-dimethyl-formamide at 110℃; under 760.051 Torr; for 7h;	100%
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 48h; Reagent/catalyst; Inert atmosphere;	58%
With 1,10-Phenanthroline; palladium diacetate In 1,2-dichloro-ethane at 120℃; under 760.051 Torr; for 8h;	5%

: 5978-75-6
9H-fluoren-9-amine hydrochloride

: 486-25-9
9-fluorenone

Conditions

Conditions	Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dimethyl sulfoxide at 25℃; for 5h;	99%

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Chemistry

Molecular Structure:

Molecular Formula: C₁₃H₈O
Molecular Weight: 180.202
IUPAC Name: Fluoren-9-one
Synonyms of 9H-Fluoren-9-one (CAS NO.486-25-9): 9-Fluorenone ; 9-Oxofluorene ; 9H-Fluoren-9-one ; AI3-00858 ; CCRIS 593 ; Diphenylene ketone ; EINECS 207-630-7 ; Fluoren-9-one ; Fluorenone ; HSDB 5490 ; NSC 5181
CAS NO: 486-25-9
Classification Code: Drug / Therapeutic Agent ; Mutation data ; Tumor data
Melting point: 80-83 °C
Index of Refraction: 1.667
Molar Refractivity: 53.92 cm³
Molar Volume: 144.8 cm³
Surface Tension: 52.3 dyne/cm
Density: 1.244 g/cm³
Flash Point: 144.1 °C
Enthalpy of Vaporization: 58.52 kJ/mol
Boiling Point: 341.5 °C at 760 mmHg
Vapour Pressure: 8.01E-05 mmHg at 25°C

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)		Pharmaceutical Chemistry Journal Vol. 23, Pg. 325, 1989.

Consensus Reports

9H-Fluoren-9-one (CAS NO.486-25-9) is reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Safety Profile

Hazard Codes of 9H-Fluoren-9-one (CAS NO.486-25-9): Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36/37/39-27-26
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S27: Take off immediately all contaminated clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: LL8925000
Hazard Note: Irritant
HS Code: 29143900
Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Specification

1. Fire Fighting Measures of 9H-Fluoren-9-one (CAS NO.486-25-9)
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
2. Handling and Storage
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Keep container closed when not in use.