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50809-32-0

Basic Information
CAS No.: 50809-32-0
Name: THYROID, PORCINE
Molecular Structure:
Molecular Structure of 50809-32-0 (THYROID, PORCINE)
Formula: Unspecified
Molecular Weight: 798.85200
Synonyms: THYROID LYOPHILIZED;THYROID USP;Thyroid Powder;THYROID;Available CAS No. 55-03-8;WHDH;
PSA: 95.61000
LogP: 3.92290
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Chemistry


IUPAC Name: Sodium(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
Molecular Weight: 798.85185 g/mol
Molecular Formula: C15H10I4NNaO4
H-Bond Donor: 2
H-Bond Acceptor: 5
Rotatable Bond Count: 5
Tautomer Count: 2
Exact Mass: 798.668624
MonoIsotopic Mass: 798.668624
Topological Polar Surface Area: 95.6
Heavy Atom Count: 25
Complexity: 426
Defined Atom StereoCenter Count: 1
InChI: InChI=1S/C15H11I4NO4.Na/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;/h1-2,4-5,12,21H,3,20H2,(H,22,23);/q;+1/p-1/t12-;/m0./s1
InChIKey: YDTFRJLNMPSCFM-YDALLXLXSA-M
Product Categories: Protein Extracts; Acetone Powders; Biochemicals and Reagents; Proteins and Derivatives 
Storage temp.: 2-8 °C
Flash Point: 302.3 °C
Enthalpy of Vaporization: 90.78 kJ/mol
Boiling Point: 576.3 °C at 760 mmHg
Vapour Pressure of  Thyroid (CAS NO.50809-32-0): 4.02E-14 mmHg at 25 °C

History

In the Medieval Medical School of Salerno (XII Century), there are several findings that evidence a great interest for thyroid disorders. Rogerius Salernitanus, the Salernitan surgeon and author of "Post mundi fabricam" (around 1180) was considered at that time the surgical text par excellence all over Europe. In the chapter "De bocio" of  his magnum opus he describes several pharmacological and surgical cures, some of which nowadays are reappraised quite scientifically effective. In 1656, the Thyroid (CAS NO.50809-32-0) was first identified by the anatomist Thomas Wharton whose name is also eponymised in Wharton's duct of the submandibular gland. Thyroxin was identified only in the 19th century.

Uses

 Thyroid (CAS NO.50809-32-0) controls how quickly the body burns energy, makes proteins, and it also controls how sensitive the body should be to other hormones.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 291mg/kg (291mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: IRRITABILITY
New England Journal of Medicine. Vol. 256, Pg. 459, 1957.
women TDLo oral 48gm/kg/26W-I (48000mg/kg) CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): SWEATING: OTHER
Archives of Internal Medicine. Vol. 148, Pg. 1450, 1988.

Safety Profile

An experimental teratogen. Human systemic effects by ingestion: cardiomyopathy, dyspnea, and sweating. When heated to decomposition it emits acrid smoke and irritating fumes.
WGK Germany: 3
RTECS XP: 3575000

Specification

 Synonyms of  Thyroid (CAS NO.50809-32-0) are Porcine ; Thyroid powder porcine ; Thyradin ; Thyroid powder porcine grade i ; Thyroid powder porcine grade iii ; Thyroid lyophilized, from porcine .