Products Categories
| CAS No.: | 53617-36-0 |
|---|---|
| Name: | 1-METHYL-4-(PIPERIDIN-4-YL)-PIPERAZINE |
| Article Data: | 6 |
| Molecular Structure: | |
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|
|
| Formula: | C10H21N3 |
| Molecular Weight: | 183.297 |
| Synonyms: | 1-Methyl-4-(4-piperidinyl)piperazine;1-Methyl-4-(piperidin-4-yl)piperazine;(1-methyl-4-piperidin-4-yl)-piperazine; |
| Density: | 0.992g/cm3 |
| Melting Point: | 53-56oC |
| Boiling Point: | 260.9oC at 760 mmHg |
| Flash Point: | 113.8oC |
| Solubility: | Soluble in water. |
| Hazard Symbols: |
 Xi
|
| PSA: | 18.51000 |
| LogP: | 0.19040 |
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- 548773-13-32-amino-4,6-dimethylpyrimidine-5-carboxylic acid
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| 100% | |
| With palladium on activated charcoal; hydrogen In methanol at 20℃; under 3750.38 Torr; for 2h; | 74.9% |
- 109-01-3
1-methyl-piperazine
- 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; | 60% |
| Stage #1: 1-methyl-piperazine; N-tert-butyloxycarbonylpiperidin-4-one With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 0 - 20℃; for 16h; Stage #2: With hydrogenchloride In methanol at 40℃; for 12h; | 60% |
| Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / ethanol / 12 h / 20 °C 2: hydrogenchloride / methanol / 12 h / 0 °C View Scheme |
- 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme |
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol at 40℃; for 12h; | 0.826 g |
| With hydrogenchloride In methanol at 0℃; for 12h; |
- 109-01-3
1-methyl-piperazine
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C 2: hydrogenchloride / methanol / 12 h / 40 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 3750.38 Torr View Scheme |
- 3612-20-2
1-phenylmethyl-4-piperidone
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C 2: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C / 3750.38 Torr View Scheme |
- 866087-58-3
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-carboxy-2-[3,5-dibromo-4-hydroxy-phenyl]-ethyl ester
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h; | 99% |
- 5081-36-7
3-methoxy-4-nitrobenzoic acid
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
| Conditions | Yield |
|---|---|
| With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; | 98% |
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
- 868706-61-0
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-(4-amino-3-methyl-5-nitro-benzyl)-2-[4-(4-methyl-piperazin-1-yl)piperidin-1-yl]-2-oxo-ethyl ester
| Conditions | Yield |
|---|---|
| Stage #1: 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-carboxy-ethyl ester With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 1h; Stage #2: 1-methyl-4-(piperidin-4-yl)piperazine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 4h; Stage #3: With sodium hydrogencarbonate In tetrahydrofuran; DMF (N,N-dimethyl-formamide); water | 97% |
| Stage #1: 4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-2-(4-amino-3-methyl-5-nitro-phenyl)-1-carboxy-ethyl ester With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 1h; Stage #2: 1-methyl-4-(piperidin-4-yl)piperazine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 20℃; for 4h; | 97% |
- 686297-85-8
(R)-2-tert-butoxycarbonylamino-3-(3,4-diethyl-phenyl)-propionic acid
- 53617-36-0
1-methyl-4-(piperidin-4-yl)piperazine
- 686297-90-5
{(R)-1-(3,4-diethyl-benzyl)-2-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butylester
| Conditions | Yield |
|---|---|
| With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 97% |
