CAS No.57775-29-8,CARAZOLOL HCL Suppliers

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Basic Information

Molecular Structure:
CAS No.:	57775-29-8
Name:	CARAZOLOL HCL
Article Data:	5

Formula:	C18H22 N2 O2
Molecular Weight:	298.385
Synonyms:	(R,S)-Carazolol;(?à)-Carazolol; BM 51052; Carazolol;Conducton; DL-Carazolol; Racemic Carazolol; Suacron; Suacron Praemix
EINECS:	260-945-1
Density:	1.195 g/cm³
Melting Point:	133-137 ºC
Boiling Point:	531.2 ºC at 760 mmHg
Flash Point:	275.1 ºC
Appearance:	Yellowish solid
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	26
PSA:	57.28000
LogP:	3.44970

Synthetic route

: 75-31-0
isopropylamine

: 51997-51-4
4-(2,3-epoxypropoxy)carbazole

: 57775-29-8
carazolol

Conditions

Conditions	Yield
In methanol for 6h; Reflux;	63%

: 57775-29-8
carazolol

: 76-05-1
trifluoroacetic acid

: C18H21ClN2O2*C2HF3O2

Conditions

Conditions	Yield
With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction;	79%

: 34619-03-9
tert-butyldicarbonate

: 57775-29-8
carazolol

A: 117374-78-4
(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)-2-propanol

B: 117374-79-5
(R,S)-3-N-tert-butoxycarbonylisopropylamino-2-tert-butoxycarbonyloxy-1-(carbazol-4-yloxy)propane

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane for 30h; Ambient temperature;	A 78% B 12%

...Expand

: 57775-29-8
carazolol

: 98-60-2
4-chlorobenzenesulfonyl chloride

: N-(3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)-4-chloro-N-isopropylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran Heating;	74%

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 57775-29-8
carazolol

: N-(3-(9H-carbazol-4-yloxy)-2-hydroxypropyl)-4-fluoro-N-isopropylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran Heating;	68%

: 57775-29-8
carazolol

: 122-51-0
orthoformic acid triethyl ester

: 129625-25-8
1,1',1''-Tris<4-(2-hydroxy-3-isopropylamino-n-propyloxy)-carbazolyl>methane

Conditions

Conditions	Yield
With trichloroacetic acid In dichloromethane for 2h; Ambient temperature;	26%
With trichloroacetic acid In dichloromethane for 2h; Ambient temperature;	26%

: 57775-29-8
carazolol

: 106-96-7
propargyl bromide

: C21H24N2O2

Conditions

Conditions	Yield
Stage #1: carazolol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere;	7%

: 57775-29-8
carazolol

: 117374-80-8, 117374-81-9
methyl <(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)prop-2-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature View Scheme

: 57775-29-8
carazolol

: 78859-34-4
(R)-Carazolol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme
Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme

: 57775-29-8
carazolol

: 78859-33-3
(S)-Carazolol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme
Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme

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Chemistry

The molecular structure of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is

IUPAC Name: 1-(9H-Carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Canonical SMILES: CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O
Molecular Formula: C₁₈H₂₂N₂O₂
Molecular Weight: 298.3795
EINECS: 260-945-1
Density: 1.195 g/cm³
Melting Point: 133-137 ºC
Boiling Point: 531.2 ºC at 760 mmHg
Flash Point: 275.1 ºC
Appearance: yellowish solid
Freely Rotating Bonds: 7
Polar Surface Area: 26.63 Å²
Index of Refraction: 1.652
Molar Refractivity: 91.26 cm³
Molar Volume: 249.5 cm³
Polarizability: 36.17 ×10^-24 cm³
Surface Tension: 51.7 dyne/cm
Enthalpy of Vaporization: 84.91 kJ/mol
Vapour Pressure: 4.09E-12 mmHg at 25°C
The Cas Register Number of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- is 57775-29-8. The chemical synonyms of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) are (R)-4-(2-Hydroxy-3-isopropylamino-propoxy)-carbazole ; (R)-1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; (R,S)-Carazolol ; (R)-CarazoloL ; Carvediol ; 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- ; 2-Propanol, 1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino], (2R) .

Uses

2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is used as pharmaceutical intermediate .