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| CAS No.: | 57775-29-8 |
|---|---|
| Name: | CARAZOLOL HCL |
| Molecular Structure: | |
|
|
|
| Formula: | C18H22 N2 O2 |
| Molecular Weight: | 298.385 |
| Synonyms: | (R,S)-Carazolol;(?à)-Carazolol; BM 51052; Carazolol;Conducton; DL-Carazolol; Racemic Carazolol; Suacron; Suacron Praemix |
| EINECS: | 260-945-1 |
| Density: | 1.195 g/cm3 |
| Melting Point: | 133-137 ºC |
| Boiling Point: | 531.2 ºC at 760 mmHg |
| Flash Point: | 275.1 ºC |
| Appearance: | Yellowish solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22-36/37/38 |
| Safety: | 26 |
| PSA: | 57.28000 |
| LogP: | 3.44970 |
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- 99170-93-1N-Methyl-2-oxazolamine
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| Conditions | Yield |
|---|---|
| In methanol for 6h; Reflux; | 63% |
| Conditions | Yield |
|---|---|
| With glucose dehydrogenase; alpha-D-glucopyranose; maltose binding protein-RebF; RebH variant 4-V; nicotinamide adenine dinucleotide; flavin adenine dinucleotide; sodium chloride In methanol at 25℃; for 72h; pH=7.4; Enzymatic reaction; | 79% |
- 34619-03-9
tert-butyldicarbonate
- 57775-29-8
carazolol
A
- 117374-78-4
(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)-2-propanol
B
- 117374-79-5
(R,S)-3-N-tert-butoxycarbonylisopropylamino-2-tert-butoxycarbonyloxy-1-(carbazol-4-yloxy)propane
| Conditions | Yield |
|---|---|
| With sodium hydroxide In 1,4-dioxane for 30h; Ambient temperature; | A 78% B 12% |
- 57775-29-8
carazolol
- 98-60-2
4-chlorobenzenesulfonyl chloride
| Conditions | Yield |
|---|---|
| With triethylamine In tetrahydrofuran Heating; | 74% |
- 349-88-2
4-Fluorobenzenesulfonyl chloride
- 57775-29-8
carazolol
| Conditions | Yield |
|---|---|
| With triethylamine In tetrahydrofuran Heating; | 68% |
- 57775-29-8
carazolol
- 122-51-0
orthoformic acid triethyl ester
- 129625-25-8
1,1',1''-Tris<4-(2-hydroxy-3-isopropylamino-n-propyloxy)-carbazolyl>methane
| Conditions | Yield |
|---|---|
| With trichloroacetic acid In dichloromethane for 2h; Ambient temperature; | 26% |
| With trichloroacetic acid In dichloromethane for 2h; Ambient temperature; | 26% |
| Conditions | Yield |
|---|---|
| Stage #1: carazolol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.25h; Inert atmosphere; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 1.5h; Inert atmosphere; | 7% |
- 57775-29-8
carazolol
- 117374-80-8, 117374-81-9
methyl <(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)prop-2-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature View Scheme |
- 57775-29-8
carazolol
- 78859-34-4
(R)-Carazolol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme | |
| Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme |
- 57775-29-8
carazolol
- 78859-33-3
(S)-Carazolol
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 51 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 93 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme | |
| Multi-step reaction with 5 steps 1: 78 percent / NaOH / dioxane / 30 h / Ambient temperature 2: 82 percent / Ag2CO3 / toluene / 96 h / Ambient temperature 3: 46 percent / trifluoroacetic acid / CH2Cl2 / 0.25 h 4: 92 percent / sodium methoxide / methanol / 12 h / Ambient temperature 5: β-D-glucuronidase / H2O / 72 h / 37 °C View Scheme |
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Chemistry
The molecular structure of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is
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IUPAC Name: 1-(9H-Carbazol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Canonical SMILES: CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O
Molecular Formula: C18H22N2O2
Molecular Weight: 298.3795
EINECS: 260-945-1
Density: 1.195 g/cm3
Melting Point: 133-137 ºC
Boiling Point: 531.2 ºC at 760 mmHg
Flash Point: 275.1 ºC
Appearance: yellowish solid
Freely Rotating Bonds: 7
Polar Surface Area: 26.63 Å2
Index of Refraction: 1.652
Molar Refractivity: 91.26 cm3
Molar Volume: 249.5 cm3
Polarizability: 36.17 ×10-24 cm3
Surface Tension: 51.7 dyne/cm
Enthalpy of Vaporization: 84.91 kJ/mol
Vapour Pressure: 4.09E-12 mmHg at 25°C
The Cas Register Number of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- is 57775-29-8. The chemical synonyms of 2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) are (R)-4-(2-Hydroxy-3-isopropylamino-propoxy)-carbazole ; (R)-1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; (R,S)-Carazolol ; (R)-CarazoloL ; Carvediol ; 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol ; 2-Propanol, 1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- ; 2-Propanol, 1-(9H-Carbazol-4-yloxy)-3-[(1-methylethyl)amino], (2R) .
Uses
2-Propanol,1-(9H-carbazol-4-yloxy)-3-[(1-methylethyl)amino]- (CAS NO.57775-29-8) is used as pharmaceutical intermediate .