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CAS No.: | 696-60-6 |
---|---|
Name: | 4-Hydroxybenzylamine |
Article Data: | 50 |
Molecular Structure: | |
Formula: | C7H9NO |
Molecular Weight: | 123.155 |
Synonyms: | p-Cresol, a-amino- (6CI,7CI,8CI);4-(Aminomethyl)phenol;4-Hydroxybenzenemethanamine;4-Hydroxybenzylamine;NSC125720;[(4-Hydroxyphenyl)methyl]amine;p-(Aminomethyl)phenol;p-Hydroxybenzenemethanamine;p-Hydroxybenzylamine; |
Density: | 1.141 g/cm3 |
Melting Point: | 116-118°C |
Boiling Point: | 262.4 °C at 760 mmHg |
Flash Point: | 112.5 °C |
Appearance: | Light green solid |
Hazard Symbols: | Xi |
Risk Codes: | 34 |
Safety: | 26-36/37/39 |
PSA: | 46.25000 |
LogP: | 1.55120 |
Conditions | Yield |
---|---|
With ammonia; hydrogen; nickel In methanol; water at 20℃; under 760.051 Torr; for 21h; | 100% |
With ammonia; hydrogen; Raney nickel In methanol; water at 20℃; under 760.051 Torr; for 21h; | 100% |
With ammonium hydroxide; hydrogen; sodium hydroxide In water at 50℃; under 6080.41 Torr; Temperature; Pressure; Autoclave; Large scale; | 88.9% |
Conditions | Yield |
---|---|
Stage #1: 4-methoxy-benzylamine With hydrogen bromide In water at 120 - 126℃; Stage #2: With sodium hydroxide In water Cooling; | 92.5% |
With hydrogen iodide at 130℃; | |
With hydrogen iodide at 150℃; | |
With 2-acetoacetic acid Acidic conditions; |
4-(benzyloxy)benzylamine
4-aminomethylphenol
Conditions | Yield |
---|---|
palladium-carbon catalyst In tetrahydrofuran; water; hydrogen | 85% |
With ammonium hydroxide; hydrogen; palladium on activated charcoal In ethanol at 0℃; under 760 Torr; for 2h; | 83% |
With ammonium hydroxide; hydrogen; palladium on activated charcoal In ethanol at 0℃; under 760 Torr; for 1h; Yield given; |
Conditions | Yield |
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97% | |
With ammonia; hydrogen; nickel In methanol for 144h; | 93% |
With potassium hydroxide; Raney Ni-Al; water at 90℃; | 89% |
Conditions | Yield |
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With sodium azide; triphenylphosphine In dichloromethane; N,N-dimethyl-formamide at 90℃; for 5h; Substitution; Mitsunobu reaction; Staudinger reaction; | 95% |
4-benzyloxybenzonitrile
4-aminomethylphenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / LiAlH4, AlCl3 / diethyl ether / 2 h / 25 °C 2: 83 percent / H2, NH4OH / 10percent Pd/C / ethanol / 2 h / 0 °C / 760 Torr View Scheme | |
Multi-step reaction with 2 steps 1: LiAlH4, AlCl3 / diethyl ether / 2 h / 25 °C 2: H2, aq. NH3 / 10percent Pd-C / ethanol / 1 h / 0 °C / 760 Torr View Scheme |
di-tert-butyl dicarbonate
A
4-aminomethylphenol
B
tert-butyl (4-hydroxybenzyl)carbamate
Conditions | Yield |
---|---|
In tetrahydrofuran; water |
Conditions | Yield |
---|---|
With ammonia In water at 100℃; for 24h; Sealed bottle; |
4-hydroxybenzaldehyde oxime
4-aminomethylphenol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: H2 / Raney-Ni 2: aq. HCl View Scheme | |
With lithium aluminium tetrahydride |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid / acetic acid 2: hydrogenchloride / ethanol; water / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: zinc(II) chloride; benzene / 70 - 80 °C View Scheme |
Molecular Structure of Phenol,4-(aminomethyl)- (CAS No. 696-60-6):
Systematic Name: 4-(Aminomethyl)phenol
Molecular Formula: C7H9NO
Molecular Weight: 123.15
CAS Registry Number: 696-60-6
Melting Point: 116-118°C
Index of Refraction: 1.593
Molar Refractivity: 36.58 cm3
Molar Volume: 107.8 cm3
Surface Tension: 50.9 dyne/cm
Density: 1.141 g/cm3
Flash Point: 112.5 °C
Enthalpy of Vaporization: 52.04 kJ/mol
Boiling Point: 262.4 °C at 760 mmHg
Vapour Pressure: 0.0067 mmHg at 25°C
Product Categories: Anilines, Aromatic Amines and Nitro Compounds
Structure Descriptors of Phenol,4-(aminomethyl)- (CAS No. 696-60-6):
SMILES: Oc1ccc(cc1)CN
InChI: InChI=1/C7H9NO/c8-5-6-1-3-7(9)4-2-6/h1-4,9H,5,8H2
InChIKey: RQJDUEKERVZLLU-UHFFFAOYAL
Std. InChI: InChI=1S/C7H9NO/c8-5-6-1-3-7(9)4-2-6/h1-4,9H,5,8H2
Std. InChIKey: RQJDUEKERVZLLU-UHFFFAOYSA-N
Safety Information of Phenol,4-(aminomethyl)- (CAS No. 696-60-6):
Hazard Codes: Xi
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 2735
Hazard Note: Irritant
HazardClass: IRRITANT, CORROSIVE
Phenol,4-(aminomethyl)- with cas registry number of 696-60-6 is also called 4-Hydroxybenzylamine ; NSC 125720 ; para-Hydroxybenzylamine .