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CAS No.: | 6974-32-9 |
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Name: | beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate |
Article Data: | 48 |
Molecular Structure: | |
Formula: | C28H24O9 |
Molecular Weight: | 504.493 |
Synonyms: | Ribofuranose,1-acetate 2,3,5-tribenzoate, b-D- (6CI,8CI);1-O-Acetyl-2,3,4-tri-O-benzoyl-b-D-ribofuranose;1-O-Acetyl-2,3,5-tri-O-benzoyl-b-D-ribofuranose;1-O-Acetyl-2,3,5-tri-O-benzoyl-b-D-ribose;1-O-Acetyltri-O-benzoyl-b-D-ribofuranose;2,3,5-Tri-O-benzoyl-b-D-ribofuranosylacetate;ABR;NSC 23349;1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose;1-O-Acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose; |
EINECS: | 230-220-4 |
Density: | 1.35 g/cm3 |
Melting Point: | 128-130 °C |
Boiling Point: | 621 °C at 760 mmHg |
Flash Point: | 264.3 °C |
Appearance: | white to light yellow crystal powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/38 |
Safety: | 22-24/25-37/39-26 |
PSA: | 114.43000 |
LogP: | 3.58260 |
methyl 2,3,3'-tri-O-benzoyl-β-D-apiofuranoside
acetic anhydride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid at 20℃; for 0.5h; | 95% |
With sulfuric acid In ethyl acetate at 50 - 60℃; | 30 g |
With sulfuric acid In acetic acid at 0 - 20℃; for 5h; |
acetic anhydride
2,3,5-Tri-O-benzoyl-D-ribofuranose
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With pyridine at 40℃; Cooling with ice; | 92.1% |
With sulfuric acid; acetic acid | 78% |
With sulfuric acid; acetic acid 1.) 0-5 deg C, 0.5 h, 2.) 20 deg C, 1 h; | 74% |
acetic anhydride
N6,N6,2',3',5'-pentabenzoyl-β-D-adenosine
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In dichloromethane at 10 - 20℃; for 12h; | 70.9% |
1,2,3,5-tetra-O-benzoyl-β-D-ribofuranose
acetic anhydride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate at 0℃; for 1h; | 51% |
With zinc(II) chloride | |
With boron fluoride ether |
O2,O3,O5-Tribenzoyl-D-ribose
acetic anhydride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With pyridine |
methanol
D-ribose
benzoyl chloride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With pyridine; hydrogenchloride; dichloromethane Behandeln der gebildeten Benzoyl-Derivate mit Bromwasserstoff in Essigsaeure und Behandeln in Chloroform mit Acetanhydrid und Pyridin; | |
With pyridine; hydrogenchloride; chloroform Behandeln des danach isolierten Reaktionsprodukts mit Acetanhydrid und Essigsaeure unter Zusatz von Schwefelsaeure; |
benzoyl chloride
O1-Acetyl-O2,O5-dibenzoyl-β-D-ribofuranose
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With pyridine |
Conditions | Yield |
---|---|
durch partielle Benzoylierung, Hydrolyse (wss. Schwefelsaeure) und Acetylierung dargestellt; |
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
acetic anhydride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With pyridine Ambient temperature; Yield given; |
acetic anhydride
methyl 2,3,5-tri-O-benzoyl-αβ-D-ribofuranoside
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
Conditions | Yield |
---|---|
With sulfuric acid; acetic acid at 4 - 5℃; Yield given; | |
With sulfuric acid; acetic acid at -5℃; for 10h; Inert atmosphere; | 29.8 g |
With sulfuric acid In acetic acid at 0 - 20℃; for 5h; | 6 g |
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The 1-O-Acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose, with the CAS registry number 6974-32-9, is also known as beta-D-Ribofuranose, 1-acetate 2,3,5-tribenzoate. It belongs to the product categories of Pharmaceutical Intermediates; Sugars, Carbohydrates & Glucosides; Chiral; Carbohydrates; (intermediate of clofarabine); Biochemistry; Nucleosides, Nucleotides & Related Reagents; O-Substituted Sugars; Ribose; Riboses and 2'-Deoxyriboses; Sugars; Nucleic acids; Carbohydrates & Derivatives. Its EINECS registry number is 230-220-4. This chemical's molecular formula is C28H24O9 and molecular weight is 504.48. Its IUPAC name is called [(2R,3R,4R,5S)-5-acetyloxy-3,4-dibenzoyloxyoxolan-2-yl]methyl benzoate. This chemical can be used as pharmaceutical intermediates.
Physical properties of 1-O-Acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose: (1)ACD/LogP: 3.18; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.18; (4)ACD/LogD (pH 7.4): 3.18; (5)ACD/BCF (pH 5.5): 154.86; (6)ACD/BCF (pH 7.4): 154.86; (7)ACD/KOC (pH 5.5): 1285.78; (8)ACD/KOC (pH 7.4): 1285.78; (9)#H bond acceptors: 9; (10)#Freely Rotating Bonds: 12; (11)Index of Refraction: 1.61; (12)Molar Refractivity: 129.52 cm3; (13)Molar Volume: 373.4 cm3; (14)Surface Tension: 59.4 dyne/cm; (15)Density: 1.35 g/cm3; (16)Flash Point: 264.3 °C; (17)Enthalpy of Vaporization: 92.02 kJ/mol; (18)Boiling Point: 621 °C at 760 mmHg; (19)Vapour Pressure: 2.41E-15 mmHg at 25°C.
Preparation: this chemical can be prepared by acetic acid anhydride and methyl 2,3,5-tri-O-benzoyl-a-L-arabinofuranoside. This reaction will need reagent H2SO4 conc. and solvent acetic acid. The reaction time is 4 hours. The yield is about 95%.
Uses of 1-O-Acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose: it can be used to produce 5-methyl-1-(tri-O-benzoyl-a-L-arabinofuranosyl)-1H-pyrimidine-2,4-dione by heating. This reaction will need reagent Me3SiNHSiMe3, Me3SiCl, SnCl4 and solvent acetonitrile with reaction time of 1 hour. The yield is about 60%.
When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing and eye/face protection.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C(O[C@@H]3O[C@@H]([C@@H](OC(=O)c1ccccc1)[C@H]3OC(=O)c2ccccc2)COC(=O)c4ccccc4)C
(2)InChI: InChI=1/C28H24O9/c1-18(29)34-28-24(37-27(32)21-15-9-4-10-16-21)23(36-26(31)20-13-7-3-8-14-20)22(35-28)17-33-25(30)19-11-5-2-6-12-19/h2-16,22-24,28H,17H2,1H3/t22-,23-,24-,28-/m1/s1
(3)InChIKey: GCZABPLTDYVJMP-CBUXHAPBBG