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72590-77-3

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Basic Information
CAS No.: 72590-77-3
Name: 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
Article Data: 2
Molecular Structure:
Molecular Structure of 72590-77-3 (11beta,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate)
Formula: C28H40 O7
Molecular Weight: 488.621
Synonyms: 17a-Butyryloxy-11b-hydroxy-21-propionyloxy-4-pregnene-3,20-dione;Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone buteprate;Hydrocortisone probutate; Pandel; TS 408
Density: 1.20
Melting Point: 122℃
Boiling Point: 608.9°C at 760 mmHg
Flash Point: 194.7°C
Safety: Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. An experimental teratogen. A skin irritant. A steroid. When heated to decomposition it emits toxic fumes. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-21-PHOSPHATE; HYDROCORTISONE SODIUM SUCCINATE.
PSA: 106.97000
LogP: 4.09350
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Chemistry

Hydrocortisone 17-butyrate 21-propionate(72590-77-3)'s molecular formula is C24H40O7  and its formula weight is 488.613.
Hydrocortisone 17-butyrate 21-propionate(72590-77-3) has a  melting point of  122°C.
The molecular structure of hydrocortisone 17-butyrate 21-propionate(72590-77-3):

Uses

Used as cortical hormone, it has local anti-inflammatory effect and contraction of blood vessels. Applied to eczema, all kinds of dermatitis, psoriasis, pruritus, insect bites, flat red planus, chronic nummular erythema and so on.

Production

By the reaction of butyric acid hydrocortisone and propanoic anhydride,  hydrocortisone butyrate propionate can be obtained.

Toxicity Data With Reference

1.   

skn-rbt 1000 ppm MLD

   YACHDS    Yakuri to Chiryo. Pharmacology and Therapeutics. 9 (1981),3023.
2.   

orl-rat LD50:5120 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.
3.   

ipr-rat LD50:1420 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.
4.   

scu-rat LD50:3260 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.
5.   

orl-mus LD50:6720 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.
6.   

ipr-mus LD50:1660 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.
7.   

scu-mus LD50:1980 mg/kg

   JTSCDR    Journal of Toxicological Sciences. 6 (Suppl)(1981),1.

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. An experimental teratogen. A skin irritant. A steroid. When heated to decomposition it emits toxic fumes. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-21-PHOSPHATE; HYDROCORTISONE SODIUM SUCCINATE.