CAS No.73874-95-0,4-N-Boc-aminopiperidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	73874-95-0
Name:	4-N-Boc-aminopiperidine
Article Data:	42
Cas Database

Formula:	C₁₀H₂₀N₂O₂
Molecular Weight:	236.742
Synonyms:	4-N-Boc-amino-piperidine;4-(N-tert-Butoxycarbonylamino)piperidine;4-Boc-AminoPiperidine;4-tert-Butoxycarbonyl-aminopiperidine;4-(N-BOC-amino) piperidine;4-N-Boc-Amino Piperidine;4-(Boc-amino)piperidine;tert-butyl piperidin-4-ylcarbamate;4-(N-Boc-amino)piperidine;4-Boc-amino piperidine;4-Boc-aminopiperindine;4-N-(tert-Butoxycarbonyl)aminopiperidine;N-Boc-piperidin-4-amine;tert-butyl N-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)carbamate;
EINECS:	616-026-6
Density:	1.02 g/cm³
Melting Point:	162-166 °C
Boiling Point:	304.8 °C at 760 mmHg
Flash Point:	138.2 °C
Appearance:	Off-white solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-37/39
PSA:	50.36000
LogP:	1.98280

Synthetic route

: 73889-19-7
tert-butyl (1-benzylpiperidin-4-yl)carbamate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In methanol for 12h;	99%
With hydrogen; palladium 10% on activated carbon In methanol for 12h;	99%
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 18h;	97%

: C17H24N2O2

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol at 70℃; under 6000.6 - 7500.75 Torr; for 4h; Reagent/catalyst; Temperature;	90.7%

: 159874-20-1
1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 2068.59 Torr;
palladium In ethanol	1.8 g (100%)

: 50541-93-0
4-amino-1-benzylpiperidine

4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin: 4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C 2: 95 percent / H2 / Pd/C / methanol / 20 °C View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

1.) NaH; 2.) SOCl2: 1.) NaH; 2.) SOCl2

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C 2: 95 percent / H2 / Pd/C / methanol / 20 °C View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / acetonitrile / 1 h / 20 °C 2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 99 percent / CH2Cl2 / 18 h / Ambient temperature 2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / acetonitrile / 1 h / 20 °C 2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / ethanol View Scheme
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; 1,4-dioxane / 25 h / 5 - 20 °C 2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 65 °C / Reflux View Scheme
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 12 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h View Scheme

: 220394-91-2
benzyl 4-isocyanatotetrahydro-1(2H)-pyridinecarboxylate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CuCl2 / 20 °C 2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr View Scheme

: 24424-99-5
di-tert-butyl dicarbonate

pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium: pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / CH2Cl2 / 18 h / Ambient temperature 2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr View Scheme

: 50541-93-0
4-amino-1-benzylpiperidine

: 24424-99-5
di-tert-butyl dicarbonate

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine; palladium dihydroxide; hydrogen In dichloromethane; water
Stage #1: 4-amino-1-benzylpiperidine; di-tert-butyl dicarbonate With triethylamine Stage #2: With palladium on activated charcoal; hydrogen
Multi-step reaction with 2 steps 1: triethylamine / tetrahydrofuran / 12 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 24 h View Scheme
Multi-step reaction with 2 steps 1: chloroform 2: acetic acid / palladium-carbon catalyst / methanol View Scheme

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Specification

The 4-N-Boc-aminopiperidine, with the CAS registry number 73874-95-0, is also known as Boc-4-aminopiperidine. It belongs to the product categories of Amines; Blocks; Pharmacetical; Pyridine Series; Pyrans, Piperidines & Piperazines; Piperidine; Piperidines; Pyrans, Piperidines & Piperazines; Building Blocks; Heterocyclic Building Blocks. This chemical's molecular formula is C₁₀H₂₀N₂O₂ and molecular weight is 200.278. Its IUPAC name is called tert-butyl N-piperidin-4-ylcarbamate. The product should be sealed and stored in cool and dry place. What's more, it should be protected from strong oxides. 4-N-Boc-aminopiperidine is used for pharmaceutical intermediates.

Physical properties of 4-N-Boc-aminopiperidine: (1)ACD/LogP: 1.16; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 4; (7)#H bond donors: 2; (8)#Freely Rotating Bonds: 3; (9)Index of Refraction: 1.48; (10)Molar Refractivity: 55.446 cm³; (11)Molar Volume: 195.2 cm³; (12)Surface Tension: 35.73 dyne/cm; (13)Density: 1.026 g/cm³; (14)Flash Point: 138.152 °C; (15)Enthalpy of Vaporization: 54.522 kJ/mol; (16)Boiling Point: 304.823 °C at 760 mmHg; (17)Vapour Pressure: 0.001 mmHg at 25°C.

Preparation of 4-N-Boc-aminopiperidine: this chemical can be prepared by (1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester. This reaction will need reagent cyclohexene and solvent ethanol. The reaction time is 3.5 hours. The yield is about 92%.

4-N-Boc-aminopiperidine can be prepared by (1-benzyl-piperidin-4-yl)-carbamic acid tert-butyl ester

Uses of 4-N-Boc-aminopiperidine: it can be used to produce [1-(4-nitro-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester at temperature of 20 °C. This reaction will need reagents acetic acid, sodium triacetoxyborohydride and solvent tetrahydrofuran with reaction time of 20 hours. The yield is about 78%.

4-N-Boc-aminopiperidine can be used to produce [1-(4-nitro-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C)OC(=O)NC1CCNCC1
(2)InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)
(3)InChIKey: CKXZPVPIDOJLLM-UHFFFAOYSA-N