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754159-68-7

Basic Information
CAS No.: 754159-68-7
Name: 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid
Article Data: 4
Molecular Structure:
Molecular Structure of 754159-68-7 (3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid)
Formula: C29H35NO3
Molecular Weight: 445.602
Synonyms: 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid;
Density: 1.095
PSA: 49.77000
LogP: 6.60460
Synthetic route
140-10-3

(E)-3-phenylacrylic acid

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfuric acid / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / Reflux
3.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
3.2: 3 h / 10 °C
4.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
5.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
6.1: isopropyl alcohol / 15 h / 25 - 86 °C
7.1: sodium hydroxide / water
8.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
8.2: 1 h / -65 - -60 °C
View Scheme
950773-38-3

R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

124-38-9

carbon dioxide

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Stage #1: R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine With ethyl bromide; iodine; magnesium In tetrahydrofuran at 55℃; for 1h; Reflux;
Stage #2: carbon dioxide In tetrahydrofuran at -65 - -60℃; for 1h;
Stage #1: R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine With ethyl bromide; iodine; magnesium In tetrahydrofuran at 60 - 65℃; for 2h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran at -70 - -50℃; for 1h;

(+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
2.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
3.1: isopropyl alcohol / 15 h / 25 - 86 °C
4.1: sodium hydroxide / water
5.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
5.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 20 °C
2.1: potassium iodide / acetonitrile / 15 h / Reflux
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
3.2: 1 h / -60 - -25 °C
3.3: 1 h / 0 - 20 °C
4.1: ammonia / ethyl acetate; water / pH 8 - 9
5.1: methanol / 50 - 65 °C
6.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
2.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
3.2: 1.5 h / -70 - -60 °C / Inert atmosphere
3.3: -10 - 25 °C
4.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
4.2: 10 - 15 °C
View Scheme

(+/-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropyl alcohol / 15 h / 25 - 86 °C
2.1: sodium hydroxide / water
3.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
3.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
1.2: 1 h / -60 - -25 °C
1.3: 1 h / 0 - 20 °C
2.1: ammonia / ethyl acetate; water / pH 8 - 9
3.1: methanol / 50 - 65 °C
4.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 2 steps
1.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
1.2: 1.5 h / -70 - -60 °C / Inert atmosphere
1.3: -10 - 25 °C
2.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
2.2: 10 - 15 °C
View Scheme
106-41-2

4-bromo-phenol

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfuric acid / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / Reflux
3.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
3.2: 3 h / 10 °C
4.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
5.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
6.1: isopropyl alcohol / 15 h / 25 - 86 °C
7.1: sodium hydroxide / water
8.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
8.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / 12 h / 120 - 125 °C
2.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C
2.2: 5.5 h / 15 °C / Reflux
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
4.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
5.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
6.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
6.2: 1.5 h / -70 - -60 °C / Inert atmosphere
6.3: -10 - 25 °C
7.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
7.2: 10 - 15 °C
View Scheme
156755-23-6

6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate; sodium iodide / acetone / Reflux
2.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
2.2: 3 h / 10 °C
3.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
4.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
5.1: isopropyl alcohol / 15 h / 25 - 86 °C
6.1: sodium hydroxide / water
7.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
7.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate; sodium iodide / acetone / 25 - 30 °C
1.2: 5.5 h / 15 °C / Reflux
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
3.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
4.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
5.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
5.2: 1.5 h / -70 - -60 °C / Inert atmosphere
5.3: -10 - 25 °C
6.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
6.2: 10 - 15 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 8 steps
1.1: potassium carbonate / 60 - 65 °C
2.1: sodium hydroxide / water / 45 - 50 °C
3.1: ethanol / 5.83 h / 0 - 75 °C
4.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
6.1: toluene / 1 h / 0 - 35 °C
7.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
8.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
8.2: 1 h / -70 - -50 °C
View Scheme
156755-24-7

methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / 1,2-dimethoxyethane / 0.17 h
1.2: 3 h / 10 °C
2.1: triethylamine / dichloromethane / 12 h / 25 - 30 °C
3.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
4.1: isopropyl alcohol / 15 h / 25 - 86 °C
5.1: sodium hydroxide / water
6.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
6.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 4 h / 5 - 10 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C
3.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
4.2: 1.5 h / -70 - -60 °C / Inert atmosphere
4.3: -10 - 25 °C
5.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
5.2: 10 - 15 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 45 - 50 °C
2.1: ethanol / 5.83 h / 0 - 75 °C
3.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
5.1: toluene / 1 h / 0 - 35 °C
6.1: tetrahydrofuran / 4.5 h / 60 - 65 °C
7.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
7.2: 1 h / -70 - -50 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydroxide / water / 45 - 50 °C
2.1: ethanol / 5.83 h / 0 - 75 °C
3.1: hydrogenchloride / water; toluene / 1 h / 20 - 25 °C
4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 50 - 55 °C
5.1: toluene / 1 h / 0 - 35 °C
6.1: iodine; lithium aluminium tetrahydride / tetrahydrofuran / 2.25 h / 0 - 65 °C
7.1: iodine; magnesium; ethyl bromide / tetrahydrofuran / 2 h / 60 - 65 °C / Inert atmosphere
7.2: 1 h / -70 - -50 °C
View Scheme
250214-37-0

(+/-)-toluene-4-sulphonic acid 3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl ester

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 30 h / 95 - 100 °C / autoclave; Sealed tube
2.1: isopropyl alcohol / 15 h / 25 - 86 °C
3.1: sodium hydroxide / water
4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
4.2: 1 h / -65 - -60 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium iodide / acetonitrile / 15 h / Reflux
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / Reflux
2.2: 1 h / -60 - -25 °C
2.3: 1 h / 0 - 20 °C
3.1: ammonia / ethyl acetate; water / pH 8 - 9
4.1: methanol / 50 - 65 °C
5.1: ammonia / water / pH 8 - 9
View Scheme
Multi-step reaction with 3 steps
1.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 4 h / 50 - 55 °C / Inert atmosphere
2.2: 1.5 h / -70 - -60 °C / Inert atmosphere
2.3: -10 - 25 °C
3.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C
3.2: 10 - 15 °C
View Scheme
1135493-18-3

C20H18O8*C28H34BrNO

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water
2.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 1 h / 55 °C / Reflux
2.2: 1 h / -65 - -60 °C
View Scheme

(-)-N,N-Diisopropyl-3-(2-benzyloxy-5-carboxyphenyl)-3-phenylpropylamine hydrochloride

754159-68-7

4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ammonia / ethyl acetate; water / pH 8 - 9
2: methanol / 50 - 65 °C
3: ammonia / water / pH 8 - 9
View Scheme
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    754159-68-7

    3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid 754159-68-7

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    3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid 754159-68-7

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    3-[(1R)-3-[BIS(1-METHYLETHYL)AMINO]-1-PHENYLPROPYL]-4-(PHENYLMETHOXY)BENZOIC ACID

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    Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)-

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  • 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid,754159-68-7

  • Casno:

    754159-68-7

    3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid,754159-68-7

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    instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China

    Wuhan MoonZY Biological Technology Co.,Ltd (MoonzyBio)is located in Wuhan city,hubei province,China,we have a group of senior technical backbones, specialized in R & D and sales in

  • Wuhan MoonZY Biological Technology Co.,Ltd

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    Business Type:Lab/Research institutions

    Tel:13545198479

    Address:203,Building 3, International Enterprise Center, No. 1 Guanshan 2nd Road, East Lake New Technology Development Zone,

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  • (R)-4-Benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)benzoic acid

  • Casno:

    754159-68-7

    (R)-4-Benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)benzoic acid

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    With about ten years experiences in the field of pharmaceutical chemicals, Yierdechem has established solid business cooperation relationships with many large companys worldwide.As a leading supplier of API and pharmaceutical intermediates, holds its

    yierdechem is a young and potential team, with about ten years experiences in the field of pharmaceutical intermediate and fine chemicals, yierdechem has established solid business

  • Hangzhou Yierdechem Co. Ltd

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    Business Type:Other

    Tel:+86-571-86904883

    Address:903,zhijiang Minglou, Xiasha EDA, Hangzhou City 310018,P.R.China

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  • FT-0773503

  • Casno:

    754159-68-7

    FT-0773503

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    High Quality Best Price Storage:Store in dry, dark and ventilated place Application:Chemical Synthesis Intermediate

    Finetech Industry Limited is a company in England,which specializing in developing, manufacturing and marketing fine organic compounds and intermediates for the fine chemical and p

  • Finetech Industry Limited

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    Business Type:Trading Company

    Tel:86-27-87465837

    Address:wuhan

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  • 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)Benzoic acid

  • Casno:

    754159-68-7

    3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)Benzoic acid

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0

    Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four yearsOur key scientific leadership team has gained experience in top research and developmen

    Debyesci is here who supplied several kinds of chemical products to global pharmaceutical, drug discovery, agrochemical and biotechnology industries for four years Our key scienti

  • Debye Scientific

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+85221376140

    Address:Rm. 19C, Lockhart Ctr., 301-307 Lockhart Rd., Wan Chai

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Chemistry

Product Name: Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)- (CAS NO.754159-68-7)

Molecular Formula: C29H35NO3
Molecular Weight: 445.59g/mol
Mol File: 754159-68-7.mol
Density: 1.095

Specification

 Benzoicacid, 3-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)- , its CAS NO. is 754159-68-7, the synonym is 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-(phenylmethoxy)benzoic acid .