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75806-84-7

Basic Information
CAS No.: 75806-84-7
Name: 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
Article Data: 2
Molecular Structure:
Molecular Structure of 75806-84-7 (2-Bromo-3-chloro-5-(trifluoromethyl)pyridine)
Formula: C6H2BrClF3N
Molecular Weight: 260.441
Synonyms: 2-Bromo-3-chloro-5-trifluoromethylpyridine;3-Chloro-5-trifluoromethyl-2-bromopyridine;
Density: 1.805 g/cm3
Boiling Point: 226.921 °C at 760 mmHg
Flash Point: 91.039 °C
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36-37/39
PSA: 12.89000
LogP: 3.51630
Synthetic route
69045-84-7

2,3-dichloro-5-trifluoromethylpyridine

75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With trimethylsilyl bromide at 100℃; for 15h; Inert atmosphere;90%
76041-71-9

3-chloro-2-hydroxy-5-(trifluoromethyl)pyridine

75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With phosphorus(V) oxybromide at 150℃; for 6h; Temperature;58%
5006-66-6

6-hydroxy-3-pyridinecarboxylic acid

75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen fluoride; sulfur tetrafluoride / 12 h / 100 °C / 1125.11 Torr / Autoclave
2: N-chloro-succinimide / N,N-dimethyl-formamide; 1-methyl-pyrrolidin-2-one / 8 h / 20 °C
3: phosphorus(V) oxybromide / 6 h / 150 °C
View Scheme
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

191171-55-8

2-anilineboronic acid pinacol ester

824953-11-9

2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]aniline

Conditions
ConditionsYield
With water; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In dimethyl sulfoxide for 16h;95%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

1450903-41-9

2-(trifluoromethyl)-N-vinylbenzamide

658066-35-4

fluopyram

Conditions
ConditionsYield
With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate In water; dimethyl sulfoxide at 23℃; for 16h; Irradiation; Inert atmosphere; Sealed tube; Cooling; regioselective reaction;93%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

80194-70-3

3-chloro-2-cyano-5-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 2-bromo-3-chloro-5-(trifluoromethyl)pyridine With 4-pyrrolidin-1-ylpyridine In ethanol for 6h; Reflux; Large scale;
Stage #2: lithium cyanide In water; 1,2-dichloro-ethane at 80℃; for 2h; Large scale;
88.1%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

206446-38-0

(1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide

C9H8ClF3N2

Conditions
ConditionsYield
Stage #1: 2-bromo-3-chloro-5-(trifluoromethyl)pyridine; (1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 50℃; for 18h;
Stage #2: With hydrogenchloride In methanol; water at 20℃; for 60h;
88%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

1263188-55-1

(7‐methyl‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐7‐yl)methanol

7-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}methyl)-7-methyl-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2.33333h; Inert atmosphere;88%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

13313-25-2

N-benzoylethyleneimine

N-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl)benzamide

Conditions
ConditionsYield
With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate In water; dimethyl sulfoxide at 23℃; for 16h; Irradiation; Inert atmosphere; Sealed tube; Cooling; regioselective reaction;82%
75806-84-7

2-bromo-3-chloro-5-(trifluoromethyl)pyridine

4-(trifluoromethyl)-N-vinylbenzamide

659745-39-8

N-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)ethyl)-4-(trifluoromethyl)benzamide

Conditions
ConditionsYield
With Cyclohexanethiol; 10-phenyl-10H-phenothiazine; sodium formate In water; dimethyl sulfoxide at 23℃; for 16h; Irradiation; Inert atmosphere; Sealed tube; Cooling; regioselective reaction;82%
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    75806-84-7 C6H2BrClF3N 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine

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Chemistry

Molecular Structure of 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine (CAS NO.75806-84-7):


IUPAC: 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine
Molecular Formula: C6H2BrClF3N
Molecular Weight: 260.44
Product Categories:Halides;Pyridines;Pyridine
Density: 1.804 g/cm3
Flash Point: 91oC
Boiling Point: 226.9oC at 760 mmHg
Index of Refraction: 1.492 
Molar Volume: 144.3 cm3
Surface Tension: 32.6 dyne/cm
Molar Refractivity: 41.9 cm3
Enthalpy of Vaporization: 44.46 kJ/mol
Vapour Pressure: 0.12 mmHg at 25oC
SMILES: Clc1cc(cnc1Br)C(F)(F)F 
InChI: InChI=1/C6H2BrClF3N/c7-5-4(8)1-3(2-12-5)6(9,10)11/h1-2H 
InChIKey: SMTKGMYGLYWNDL-UHFFFAOYAS

Safety Profile

Safety Information of 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine (CAS NO.75806-84-7):
Hazard Codes: XiIrritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
Hazard Note: Irritant
HazardClass: IRRITANT

Specification

 2-Bromo-3-bromomethylthiophene with cas registry number of 75806-84-7 is also known as 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine ; Pyridine, 2-bromo-3-chloro-5-(trifluoromethyl)- ; 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine 97% . It would emit acrid smoke and irritating fumes when heated to decomposition . 2-Bromo-3-bromomethylthiophene with cas registry number of 75806-84-7 is used as a pharmaceutical intermediate .