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7646-67-5

Basic Information
CAS No.: 7646-67-5
Name: N-(2-Hydroxyethyl)acrylamide, HEAA
Article Data: 22
Molecular Structure:
Molecular Structure of 7646-67-5 (N-(2-Hydroxyethyl)acrylamide,  HEAA)
Formula: C5H9NO2
Molecular Weight: 115.132
Synonyms: 2-Propenamide, N-(2-hydroxyethyl)-;
Density: 1.05 g/cm3
Boiling Point: 328.476 °C at 760 mmHg
Flash Point: 152.457 °C
Solubility: Soluble in water
Hazard Symbols: HarmfulXn
Risk Codes: 22-36/37/38
Safety: 26
PSA: 49.33000
LogP: -0.32820
Synthetic route

C7H15NO3

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 4-methoxy-phenol; potassium hydroxide In glycerol at 200℃; Pyrolysis;95%

β-hydroxyethylamino-N-hydroxyethylpropionic acid amide

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 4,4'-butylidenebis(6-tert-butyl-m-cresol); copper(II) bis(trifluoromethanesulfonate) at 140℃; for 8h; Inert atmosphere;94%
With sulfuric acid; 4-methoxy-phenol at 180 - 220℃; under 450.045 Torr; for 6h;
141-43-5

ethanolamine

814-68-6

acryloyl chloride

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
In chloroform at 0℃; for 2h;87%
With potassium hydroxide In methanol at 0℃;73%
In chloroform 1.) 0 deg C, 28 min; 2.) 25 deg C, 1 h;70%

N-morpholinopropionylethanolamine

108-24-7

acetic anhydride

A

1696-20-4

4-acetylmorpholine

B

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
Stage #1: N-morpholinopropionylethanolamine; acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine Reagent/catalyst; Reflux;
A 67%
B 81.7%

N-hydroxyethyl norborn-5-ene-2-carboxamide

A

7646-67-5

N-hydroxyethylacrylamide

B

542-92-7

cyclopenta-1,3-diene

Conditions
ConditionsYield
at 260 - 440℃; under 30.003 - 39.979 Torr; for 41h; Product distribution / selectivity; Gaseous-phase pyrolysis; Continuous reaction;A 80.7%
B n/a
2051-76-5

acrylic acid anhydride

141-43-5

ethanolamine

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
Stage #1: ethanolamine With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 10H-phenothiazine In acetonitrile Electric arc;
Stage #2: acrylic acid anhydride In acetone at 25 - 50℃; for 2h; Solvent;
76%

((2-aminoethyl)acrylate)methyl isobutyl ketimine

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With water; 4-methoxy-phenol In methanol at 20℃; for 3h;13.4%
141-43-5

ethanolamine

79-10-7

acrylic acid

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 1,2-dichloro-ethane; tetracarbonyl nickel; acetylene Reagens 4:Kohlenmonoxid;
477572-64-8

N-{2-[(2-acryloylamino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethyl}-acrylamide

A

7646-67-5

N-hydroxyethylacrylamide

B

123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water In tetrahydrofuran pH=5.0; Kinetics; Further Variations:; pH-values;
141-43-5

ethanolamine

814-68-6

acryloyl chloride

A

2-methacrylethylacrylamide

B

7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
In chloroform
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  • N-(2-Hydroxyethyl)acrylamide, HEAA 7646-67-5

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    N-(2-Hydroxyethyl)acrylamide, HEAA 7646-67-5

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  • N-(2-Hydroxyethyl)acrylamide

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    N-(2-Hydroxyethyl)acrylamide

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    Products Name: N-(2-Hydroxyethyl)acrylamide CAS NO. : 7646-67-5 Specification: Assay: 99%

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Specification

The N-(2-Hydroxyethyl)acrylamide, with the CAS registry number 7646-67-5, is also known as 2-Propenamide, N-(2-hydroxyethyl)-. This chemical's molecular formula is C5H9NO2 and molecular weight is 115.13. What's more, its systematic name is the same with its product name.

Physical properties about this chemical are: (1)ACD/LogP: -1.372; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.37; (4)ACD/LogD (pH 7.4): -1.37; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 4.27; (8)ACD/KOC (pH 7.4): 4.27; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 49.33 Å2; (13)Index of Refraction: 1.461; (14)Molar Refractivity: 30.098 cm3; (15)Molar Volume: 109.605 cm3; (16)Polarizability: 11.932×10-24cm3; (17)Surface Tension: 36.735 dyne/cm; (18)Density: 1.05 g/cm3; (19)Flash Point: 152.457 °C; (20)Enthalpy of Vaporization: 66.155 kJ/mol; (21)Boiling Point: 328.476 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health and it is harmful if swallowed. This chemical is irritating to eyes, respiratory system and skin. In case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: O=C(\C=C)NCCO
(2) InChI: InChI=1S/C5H9NO2/c1-2-5(8)6-3-4-7/h2,7H,1,3-4H2,(H,6,8)
(3) InChIKey: UUORTJUPDJJXST-UHFFFAOYSA-N