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7646-67-5 Usage

Uses

N-Hydroxyethyl acrylamide is an amphipathic polymer that can be used for a variety of applications such as:preparation of hydrogels for the formation of a stimulo-responsive polymer for cell signaling and bioengineering researchin the synthesis of lanthanide based luminescent materials for sensors and bio-imagingformation of adhesive hydrogel for potential usage in the smart adhesives

Check Digit Verification of cas no

The CAS Registry Mumber 7646-67-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,4 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7646-67:
(6*7)+(5*6)+(4*4)+(3*6)+(2*6)+(1*7)=125
125 % 10 = 5
So 7646-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO2/c1-2-5(8)6-3-4-7/h2,7H,1,3-4H2,(H,6,8)

7646-67-5 Well-known Company Product Price

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  • Detail
  • TCI America

  • (H1262)  N-(2-Hydroxyethyl)acrylamide (stabilized with MEHQ)  >98.0%(GC)(T)

  • 7646-67-5

  • 25g

  • 250.00CNY

  • Detail
  • TCI America

  • (H1262)  N-(2-Hydroxyethyl)acrylamide (stabilized with MEHQ)  >98.0%(GC)(T)

  • 7646-67-5

  • 100g

  • 515.00CNY

  • Detail
  • TCI America

  • (H1262)  N-(2-Hydroxyethyl)acrylamide (stabilized with MEHQ)  >98.0%(GC)(T)

  • 7646-67-5

  • 500g

  • 1,160.00CNY

  • Detail
  • Aldrich

  • (697931)  N-Hydroxyethylacrylamide  contains 1,000 ppm monomethyl ether hydroquinone as stabilizer, 97%

  • 7646-67-5

  • 697931-100ML

  • 441.09CNY

  • Detail

7646-67-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-Hydroxyethyl)acrylamide

1.2 Other means of identification

Product number -
Other names N-Ethanolacrylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7646-67-5 SDS

7646-67-5Synthetic route

C7H15NO3

C7H15NO3

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 4-methoxy-phenol; potassium hydroxide In glycerol at 200℃; Pyrolysis;95%
β-hydroxyethylamino-N-hydroxyethylpropionic acid amide

β-hydroxyethylamino-N-hydroxyethylpropionic acid amide

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 4,4'-butylidenebis(6-tert-butyl-m-cresol); copper(II) bis(trifluoromethanesulfonate) at 140℃; for 8h; Inert atmosphere;94%
With sulfuric acid; 4-methoxy-phenol at 180 - 220℃; under 450.045 Torr; for 6h;
ethanolamine
141-43-5

ethanolamine

acryloyl chloride
814-68-6

acryloyl chloride

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
In chloroform at 0℃; for 2h;87%
With potassium hydroxide In methanol at 0℃;73%
In chloroform 1.) 0 deg C, 28 min; 2.) 25 deg C, 1 h;70%
N-morpholinopropionylethanolamine

N-morpholinopropionylethanolamine

acetic anhydride
108-24-7

acetic anhydride

A

4-acetylmorpholine
1696-20-4

4-acetylmorpholine

B

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
Stage #1: N-morpholinopropionylethanolamine; acetic anhydride In toluene at 20 - 80℃; for 2h; Inert atmosphere;
Stage #2: With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine Reagent/catalyst; Reflux;
A 67%
B 81.7%
N-hydroxyethyl norborn-5-ene-2-carboxamide

N-hydroxyethyl norborn-5-ene-2-carboxamide

A

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

B

cyclopenta-1,3-diene
542-92-7

cyclopenta-1,3-diene

Conditions
ConditionsYield
at 260 - 440℃; under 30.003 - 39.979 Torr; for 41h; Product distribution / selectivity; Gaseous-phase pyrolysis; Continuous reaction;A 80.7%
B n/a
acrylic acid anhydride
2051-76-5

acrylic acid anhydride

ethanolamine
141-43-5

ethanolamine

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
Stage #1: ethanolamine With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 10H-phenothiazine In acetonitrile Electric arc;
Stage #2: acrylic acid anhydride In acetone at 25 - 50℃; for 2h; Solvent;
76%
((2-aminoethyl)acrylate)methyl isobutyl ketimine

((2-aminoethyl)acrylate)methyl isobutyl ketimine

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With water; 4-methoxy-phenol In methanol at 20℃; for 3h;13.4%
ethanolamine
141-43-5

ethanolamine

acrylic acid
79-10-7

acrylic acid

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 1,2-dichloro-ethane; tetracarbonyl nickel; acetylene Reagens 4:Kohlenmonoxid;
N-{2-[(2-acryloylamino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethyl}-acrylamide
477572-64-8

N-{2-[(2-acryloylamino-ethoxy)-(4-methoxy-phenyl)-methoxy]-ethyl}-acrylamide

A

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

B

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

Conditions
ConditionsYield
With water In tetrahydrofuran pH=5.0; Kinetics; Further Variations:; pH-values;
ethanolamine
141-43-5

ethanolamine

acryloyl chloride
814-68-6

acryloyl chloride

A

2-methacrylethylacrylamide

2-methacrylethylacrylamide

B

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
In chloroform
N-acryloyl-2,2-dimethyl-1,3-oxazolidine

N-acryloyl-2,2-dimethyl-1,3-oxazolidine

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With hydrogen chloride In water-d2
C13H28N2O2

C13H28N2O2

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With sulfuric acid497 g
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical at 150℃; under 52.5053 Torr; for 48h; Inert atmosphere; Ionic liquid;
N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)acrylamide

N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)acrylamide

A

tetrahydro-2H-2-pyranol
694-54-2

tetrahydro-2H-2-pyranol

B

5-hydroxypentanal
4221-03-8

5-hydroxypentanal

C

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With water; 4-methoxy-phenol In aq. phosphate buffer at 37℃; pH=5; Kinetics;
N-hydroxyethyl norborn-5-ene-2-carboxamide

N-hydroxyethyl norborn-5-ene-2-carboxamide

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With 4-methoxy-phenol at 400 - 440℃; under 30.003 - 60.006 Torr; Pyrolysis;
C19H19NO2

C19H19NO2

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Conditions
ConditionsYield
With iron(III) chloride; 10H-phenothiazine at 150℃;8.56 g
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Trichloroacetimidate 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzoyl-α/β-D-galactopyranosyl)-α/β-D-glucopyranoside
473449-32-0

Trichloroacetimidate 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzoyl-α/β-D-galactopyranosyl)-α/β-D-glucopyranoside

2-(N-acryloylamino)ethyl (2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranoside
1318074-08-6

2-(N-acryloylamino)ethyl (2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: N-hydroxyethylacrylamide; Trichloroacetimidate 2,3,6-tri-O-benzoyl-4-O-(2,3,4,6-tetra-O-benzoyl-α/β-D-galactopyranosyl)-α/β-D-glucopyranoside In dichloromethane at 20℃; for 0.5h; Molecular sieve; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 1.53333h; Inert atmosphere;
98%
methanol
67-56-1

methanol

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

carbon monoxide
201230-82-2

carbon monoxide

dimethyl 2-((2-hydroxyethyl)carbamoyl)succinate

dimethyl 2-((2-hydroxyethyl)carbamoyl)succinate

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; N,N'-bis(2,6-dimethylphenyl)butane-2,3-diimine; toluene-4-sulfonic acid; p-benzoquinone In tetrahydrofuran at 20℃; under 3000.3 Torr; for 67h; Autoclave;98%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

acryloyl chloride
814-68-6

acryloyl chloride

2-(acrylamido)ethyl acrylate
41233-99-2

2-(acrylamido)ethyl acrylate

Conditions
ConditionsYield
With triethylamine In chloroform at 0 - 20℃; Inert atmosphere;95%
With triethylamine In dichloromethane at -10 - 20℃; for 2h; Inert atmosphere;66%
With triethylamine In chloroform for 17h; Ambient temperature;50%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2-dodecylsulfanylthiocarbonylsulfanyl-2-methyl-propionic acid
461642-78-4

2-dodecylsulfanylthiocarbonylsulfanyl-2-methyl-propionic acid

C142H257N25O52S3

C142H257N25O52S3

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In dimethyl sulfoxide at 60℃; for 24h;94%
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)acrylamide

N-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)acrylamide

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;85%
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;85%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

12-(methacrylolamino)dodecanoic acid
62839-65-0

12-(methacrylolamino)dodecanoic acid

12-methacrylamidododecanoic acid/N-hydroxyethylacrylamide copolymer

12-methacrylamidododecanoic acid/N-hydroxyethylacrylamide copolymer

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In methanol at 60℃; for 21h;84.5%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

1-(benzyloxy)-6-bromo-N-(2,4-difluorobenzyl)-4-((2,4-dimethoxybenzyl)amino)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

1-(benzyloxy)-6-bromo-N-(2,4-difluorobenzyl)-4-((2,4-dimethoxybenzyl)amino)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

(E)-1-(benzyloxy)-N-(2,4-difluorobenzyl)-4-((2,4-dimethoxybenzyl)amino)-6-(3-((2-hydroxyethyl)amino)-3-oxoprop-1-en-1-yl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

(E)-1-(benzyloxy)-N-(2,4-difluorobenzyl)-4-((2,4-dimethoxybenzyl)amino)-6-(3-((2-hydroxyethyl)amino)-3-oxoprop-1-en-1-yl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Conditions
ConditionsYield
With palladium diacetate; triethylamine In N,N-dimethyl-formamide at 100℃; for 5h; Heck Reaction;84%
di(succinimido) carbonate
74124-79-1

di(succinimido) carbonate

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2-(succinimidyl carbonate)ethyl acrylamide
1394033-15-8

2-(succinimidyl carbonate)ethyl acrylamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetonitrile for 16h;80%
In N,N-dimethyl-formamide; acetonitrile for 16h;80%
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

C8H8Cl2N4O2

C8H8Cl2N4O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 16h;80%
allyl vinyl ether
3917-15-5

allyl vinyl ether

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

N-(2-(1-(allyloxy)ethoxy)ethyl)acrylamide

N-(2-(1-(allyloxy)ethoxy)ethyl)acrylamide

Conditions
ConditionsYield
Stage #1: N-hydroxyethylacrylamide With pyridinium p-toluenesulfonate In dichloromethane at 0℃; for 0.5h;
Stage #2: allyl vinyl ether In dichloromethane at 0 - 20℃;
75%
With pyridinium p-toluenesulfonate In dichloromethane at 0 - 20℃;
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

Methacryloyl chloride
920-46-7

Methacryloyl chloride

2-(acryloylamino)-2-ethyl methacrylate

2-(acryloylamino)-2-ethyl methacrylate

Conditions
ConditionsYield
With pyridine; 4-methoxy-phenol In tetrahydrofuran at 5 - 20℃; for 13h;74%
With 4-methoxy-phenol; triethylamine In tetrahydrofuran at -10 - 20℃; for 26h;73.3%
With 4-methoxy-phenol; triethylamine In tetrahydrofuran at -10 - 20℃; for 26h;73.3%
3,4,6-tri-O-benzoyl-β-D-mannopyranose-1,2-(prop-2-ynyl orthobenzoate)
953795-87-4

3,4,6-tri-O-benzoyl-β-D-mannopyranose-1,2-(prop-2-ynyl orthobenzoate)

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

A

2-propynyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranoside
1202868-30-1

2-propynyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranoside

B

2-(acrylamido)ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranoside
1318073-99-2

2-(acrylamido)ethyl 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranoside

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonateA 70%
B 10%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

4-nitrophenyl-β-D-glucoside
2492-87-7

4-nitrophenyl-β-D-glucoside

A

D-Glucose
2280-44-6

D-Glucose

B

4-nitro-phenol
100-02-7

4-nitro-phenol

C

N-acryloyl-2-aminoethyl β-D-glucopyranoside
156884-56-9

N-acryloyl-2-aminoethyl β-D-glucopyranoside

Conditions
ConditionsYield
With β-glucosidase In water at 50℃; for 1h; Ionic liquid; Enzymatic reaction;A n/a
B n/a
C 68%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

C8H17NO2Si

C8H17NO2Si

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 13h; Inert atmosphere;68%
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

N-(2-((tetrahydro-2H-furan-2-yl)oxy)ethyl)acrylamide

N-(2-((tetrahydro-2H-furan-2-yl)oxy)ethyl)acrylamide

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;68%
2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1-4)-1,2,3,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate
736969-78-1

2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1-4)-1,2,3,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2-(N-acryloylamino)ethyl (2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranoside

2-(N-acryloylamino)ethyl (2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-(1->4)-2,3,6-tri-O-benzoyl-β-D-glucopyranoside

Conditions
ConditionsYield
Stage #1: 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1-4)-1,2,3,6-tetra-O-benzoyl-D-glucopyranosyl trichloroacetimidate; N-hydroxyethylacrylamide In dichloromethane at 20℃; for 0.5h; Molecular sieve; Inert atmosphere;
Stage #2: With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 1.53333h; Inert atmosphere;
65%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

5-nitrosalicylic acid
96-97-9

5-nitrosalicylic acid

2-acrylamidoethyl 2-hydroxy-5-nitrobenzoate

2-acrylamidoethyl 2-hydroxy-5-nitrobenzoate

Conditions
ConditionsYield
Stage #1: N-hydroxyethylacrylamide; 5-nitrosalicylic acid With dmap In tetrahydrofuran for 1.5h; Inert atmosphere;
Stage #2: With diisopropyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 19h; Inert atmosphere;
63%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)[1,2-d]-2-oxazoline
10378-06-0, 20757-53-3, 35954-65-5, 123483-77-2, 134308-33-1

2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)[1,2-d]-2-oxazoline

2-acrylamidoethyl 3,4,6-tri-O-acetyl-2-acetamide-2-deoxy-β-D-glucopyranoside

2-acrylamidoethyl 3,4,6-tri-O-acetyl-2-acetamide-2-deoxy-β-D-glucopyranoside

Conditions
ConditionsYield
With [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid In 1,2-dichloro-ethane at 90℃; for 2h;61.4%
2-Methyl-4,5-dihydrofuran
1487-15-6

2-Methyl-4,5-dihydrofuran

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

N-(2-((2-methyltetrahydrofuran-2-yl)oxy)ethyl)acrylamide

N-(2-((2-methyltetrahydrofuran-2-yl)oxy)ethyl)acrylamide

Conditions
ConditionsYield
With camphor-10-sulfonic acid In dichloromethane at 0 - 20℃; for 3.5h; Molecular sieve;58%
pyridine-3,5-dicarbonyl dichloride
15074-61-0

pyridine-3,5-dicarbonyl dichloride

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

C17H19N3O6

C17H19N3O6

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Schlenk technique; Inert atmosphere;55%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

per-O-acetyl-α-D-mannopyranose
4163-65-9

per-O-acetyl-α-D-mannopyranose

2'-acrylamidoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside
1254975-44-4

2'-acrylamidoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 0 - 20℃; for 48h;52%
2,6-Pyridinedicarbonyl dichloride
3739-94-4

2,6-Pyridinedicarbonyl dichloride

N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

bis(2-acrylamidoethyl) pyridine-2,6-dicarboxylate

bis(2-acrylamidoethyl) pyridine-2,6-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Schlenk technique; Inert atmosphere;49%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl trichloroimidate
121238-27-5

2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl trichloroimidate

2'-acrylamidoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside
1254975-44-4

2'-acrylamidoethyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside

Conditions
ConditionsYield
Stage #1: 2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl trichloroimidate With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.75h; Inert atmosphere;
Stage #2: N-hydroxyethylacrylamide In dichloromethane Inert atmosphere;
48%
N-hydroxyethylacrylamide
7646-67-5

N-hydroxyethylacrylamide

2,2-dimethoxy-propane
77-76-9

2,2-dimethoxy-propane

N-acryloyl-2,2-dimethyl-1,3-oxazolidine

N-acryloyl-2,2-dimethyl-1,3-oxazolidine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran at 20℃; for 24h;46%

7646-67-5Relevant articles and documents

Method for synthesizing acrylamide derivative

-

Paragraph 0029; 0047; 0051, (2019/10/01)

The invention relates to a method for synthesizing an acrylamide derivative from alkyl primary amine and acrylamide as raw materials and belongs to the field of chemical product synthesis methods. Themethod for synthesizing the acrylamide derivative comprises the following steps: 1) under conditions of 150-160 DEG C and 0.6-1MPa, conducting a Diels-Alder reaction on acrylamide and anthracene so as to obtain an acrylamide addition intermediate of 1:1; 2) conducting backflowing on the addition intermediate, alkyl primary amine and a catalyst for 6-20 hours at 50-180 DEG C, and conducting an amino exchange reaction so as to obtain an acrylamide derivative addition intermediate; and 3) carrying out thermal cracking on the acrylamide derivative addition intermediate at 150-180 DEG C and 1-3kPa, conducting rectification so as to obtain an acrylamide derivative, conducting sublimation recycling on anthracene, and repeating the process. The method for synthesizing the acrylamide derivative, which is provided by the invention, is free of liquid solvent, is capable of effectively reducing the content of VOCs (volatile organic compounds) in the generation process, and is simple in reaction process, easy in product and recycling raw material separation, easy in reaction condition control, high in security, high in reaction yield, small in byproduct amount, simple in aftertreatment, high in product purity and easy in industrial production.

Hydrophobic Nanoparticles Reduce the β-Sheet Content of SEVI Amyloid Fibrils and Inhibit SEVI-Enhanced HIV Infectivity

Sheik, Daniel A.,Chamberlain, Jeffrey M.,Brooks, Lauren,Clark, Melissa,Kim, Young Hun,Leriche, Geoffray,Kubiak, Clifford P.,Dewhurst, Stephen,Yang, Jerry

, p. 2596 - 2602 (2017/03/20)

Semen-derived enhancer of virus infection (SEVI) fibrils are naturally abundant amyloid aggregates found in semen that facilitate viral attachment and internalization of human immunodeficiency virus (HIV) in cells, thereby increasing the probability of infection. Mature SEVI fibrils are composed of aggregated peptides exhibiting high β-sheet secondary structural characteristics. Herein, we show that polymers containing hydrophobic side chains can interact with SEVI and reduce its β-sheet content by ~45% compared with the β-sheet content of SEVI in the presence of polymers with hydrophilic side chains, as estimated by polarization modulation-infrared reflectance absorption spectroscopy measurements. A nanoparticle (NP) formulation of this hydrophobic polymer reduced SEVI-mediated HIV infection in TMZ-bl cells by 60% compared with the control treatment. Although these NPs lacked specific amyloid-targeting groups, thus requiring high concentrations to observe biological activity, the use of hydrophobic interactions to alter the secondary structure of amyloids represents a useful approach to neutralizing the SEVI function. These results could, therefore, have general implications in the design of novel materials that can modify the activity of amyloids associated with a variety of other neurological and systemic diseases.

Method for preparing N-hydroxyethyl acrylamide

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Paragraph 0017; 0018; 0019; 0020; 0021; 0022, (2017/10/28)

The invention discloses a method for preparing N-hydroxyethyl acrylamide. Acrylic anhydride and amino-ethanol perform reaction mildly at low temperature. Acrylic acid serving as a byproduct and a product are separated in distillation mode. The N-hydroxyethyl acrylamide obtained by the method has high purity and high yield, and the production process is simple and easily available.

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