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| CAS No.: | 77-75-8 |
|---|---|
| Name: | 3-Methyl-1-pentyn-3-ol |
| Article Data: | 52 |
| Molecular Structure: | |
|
|
|
| Formula: | C6H10O |
| Molecular Weight: | 98.1448 |
| Synonyms: | 2-Butanol, 2-ethynyl-;2-Ethynyl-2-butanol;3-Hydroxy-3-methyl-1-pentyne;3-Methyl-4-pentyn-3-ol;Allotropal;Apridol;Atempol;Citodorm;Dorison;Dormalest;Dormigen;Dormiphen;Dormosan;Formison;Hesofen;Imnudorm;Meparfynol;Methylparafynol;NSC 28797;Oblivon;a-Ethyl-a-methylpropargyl alcohol; |
| EINECS: | 201-055-5 |
| Density: | 0.901 g/cm3 |
| Melting Point: | -30 °C |
| Boiling Point: | 120.5 °C at 760 mmHg |
| Flash Point: | 26.7 °C |
| Appearance: | Clear slightly yellow liquid or low melting solid |
| Hazard Symbols: |
 Xn, F+
|
| Risk Codes: | 10-22-51/53 |
| Safety: | 23-36-61 |
| Transport Information: | UN 1986 3/PG 3 |
| PSA: | 20.23000 |
| LogP: | 0.78060 |
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| Conditions | Yield |
|---|---|
| With potassium tert-butylate In tetrahydrofuran at 0℃; | 100% |
| With tetra(n-butyl)ammonium hydroxide In water; dimethyl sulfoxide at 5℃; for 1h; Favorskii-Babayan Synthesis; | 78% |
| With sodium amide |
| Conditions | Yield |
|---|---|
| In diethyl ether at -78℃; for 4h; | 66.1% |
| Conditions | Yield |
|---|---|
| In tetrahydrofuran Heating; | 52% |
| With tetrahydrofuran | |
| Stage #1: butanone; acetylenemagnesium bromide In tetrahydrofuran at 0 - 20℃; Stage #2: With ammonium chloride In tetrahydrofuran; water | |
| In tetrahydrofuran at -10 - 20℃; |
| Conditions | Yield |
|---|---|
| With potassium carbonate | |
| With potassium carbonate |
| Conditions | Yield |
|---|---|
| With ammonia |
- 14179-94-3
3-chloro-3-methylpent-1-yne
- 77-75-8
meparfynol
| Conditions | Yield |
|---|---|
| With water; calcium carbonate at 80 - 90℃; |
- 75-04-7
ethylamine
- 10575-70-9
1-bromo-3-methyl-1,2-pentadiene
A
- 14465-45-3
3-ethylamino-3-methyl-1-pentyne
C
- 77-75-8
meparfynol
| Conditions | Yield |
|---|---|
| With potassium hydroxide at 25℃; for 120h; | A 91 % Chromat. B n/a C 7 % Chromat. |
- 75-64-9
tert-butylamine
- 10575-70-9
1-bromo-3-methyl-1,2-pentadiene
A
- 1185-98-4
3-t-butylamino-3-methyl-1-pentyne
C
- 77-75-8
meparfynol
| Conditions | Yield |
|---|---|
| With potassium hydroxide at 100℃; for 5h; Yield given; | A 57 % Chromat. B n/a C 23 % Chromat. |
- Total:35 Page 1 of 1 1
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Chemistry
IUPAC Name: 3-Methyl-1-pentyn-3-ol
The MF of 3-Methyl-1-pentyn-3-ol (77-75-8) is C6H10O.
The MW of 3-Methyl-1-pentyn-3-ol (77-75-8) is 98.14.
Synonyms of 3-Methyl-1-pentyn-3-ol (77-75-8): 1-Pentyn-3-ol,3-methyl- ; 1-Pentyn-3-ol,3-methyl- ; 2-Aethinylbutanol ; 2-Butanol,2-ethynyl- ; 2-Ethinyl butanol-2 ; 2-Ethinylbutanol ; 2-Ethynyl-2-butano
Product Categories: Acetylenes;Acetylenic Alcohols & Their Derivatives;Chemistry
Form: Clear slightly yellow liquid or low melting solid
Index of Refraction: 1.448
EINECS: 201-055-5
Density: 0.901 g/ml
Flash Point: 26.7 °C
Boiling Point: 120.5 °C
Melting Point: -30 °C
Storage temp: Flammables area
Merck: 13,5870
Uses
3-Methyl-1-pentyn-3-ol (77-75-8) is used as a pharmaceutical intermediate, fish transportation hypnotic agent, special solvents, etching inhibitors, viscosity stabilizer, reduce viscosity, nickel or copper plating polishing agent, chlorinated hydrocarbon stabilizer.
Production
Derived from the reaction of acetylene with methyl ethyl ketone.
Toxicity Data With Reference
| 1. | orl-mus LD50:525 mg/kg | PSCBAY Psychopharmacology Service Center, Bulletin. 2 (1963),17. | ||
| 2. | ipr-mus LD50:525 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 218 (1953),427. | ||
| 3. | scu-mus LD50:284 mg/kg | YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. 76 (1956),181. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Moderately toxic by intraperitoneal and subcutaneous routes. Used as a soporific. Average doses may produce dermatitis, eructations (belching), psychoses and central nervous system abnormalities. Overdoses can produce coma and death. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, mist, fog. When heated to decomposition it emits acrid smoke and fumes.
Safety information of 3-Methyl-1-pentyn-3-ol (77-75-8):
Hazard Codes 
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F+
Risk Statements
10 Flammable
22 Harmful if swallowed
51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements
23 Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
36 Wear suitable protective clothing
61 Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR UN 1986 3/PG 3
WGK Germany 1
RTECS SC4900000