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Basic Information
| CAS No.: | 78-30-8 | |
|---|---|---|
| Name: | TRI-O-CRESYL PHOSPHATE | |
| Molecular Structure: | ||
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| Formula: | C21H21 O4 P | |
| Molecular Weight: | 368.369 | |
| Synonyms: | Phosphoricacid, tri-o-tolyl ester (8CI); NSC 438; Phosflex 179C; TOCP; TOKF; TOTP;Tri-o-cresyl phosphate; Tri-o-tolyl phosphate; Tris(2-tolyl) phosphate;Tris(o-cresyl) phosphate; Tris(o-methylphenyl) phosphate; Tris(o-tolyl)phosphate; o-Cresyl phosphate | |
| EINECS: | 201-103-5 | |
| Density: | 1.2 | |
| Melting Point: | -25 °C | |
| Boiling Point: | 410 °C | |
| Flash Point: | 225 °C | |
| Solubility: | 0.1mgl-1(e) | |
| Appearance: | colorless viscous liquid. | |
| Hazard Symbols: | Toxic by ingestion and skin absorption. The o- isomer is highly toxic. TLV: 0.1 mg/m3 (skin); Not Classifiable as a Human Carcinogen. | |
| Risk Codes: | 51/53-39/23/24/25 | |
| Safety: |
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or “jake.” This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-o-cresyl phosphate is more toxic than the m-form, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects. Combustible when exposed to heat or flame. Can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of POx. See also PHOSPHATES. | |
Analytical Methods: | For occupational chemical analysis use NIOSH: Triorthocresyl Phosphate, S209. |
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| PSA: | 54.57000 | |
| LogP: | 6.25670 | |
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TRI-O-CRESYL PHOSPHATE
Chemistry
MF: C21H21O4P
MW: 368.36
mp: -25 °C
bp: 410 °C
density: 1.2
Fp: 225 °C
EINECS: 201-103-5
refractive index: 1.558-1.561
Appearane: colourless, odourless, non-volatile liquid
TRIORTHOCRESYL PHOSPHATE is miscible with most organic solvents,but not miscible with water. It is Combustible.
MW: 368.36
mp: -25 °C
bp: 410 °C
density: 1.2
Fp: 225 °C
EINECS: 201-103-5
refractive index: 1.558-1.561
Appearane: colourless, odourless, non-volatile liquid
TRIORTHOCRESYL PHOSPHATE is miscible with most organic solvents,but not miscible with water. It is Combustible.
Uses
TRIORTHOCRESYL PHOSPHATE is commonly used as a plasticizer in many industrial processes.
Toxicity Data With Reference
| 1. | orl-rat LD50:1160 mg/kg | TOXID9 Toxicologist. 4 (1984),55. | ||
| 2. | ipr-rat LD50:2500 mg/kg | APCRAW Advances in Pest Control Research. 4 (1961),117. | ||
| 3. | scu-mus LDLo:12,500 mg/kg | EDWU** Beitrag zur Toxikologie Technischer Weichmachungsmittel, Heinrich Eller Dissertation .(Pharmakologischen Institut der Universitat Wurzburg,Germany.: 1937). | ||
| 4. | scu-dog LDLo:100 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473. | ||
| 5. | scu-cat LDLo:185 mg/kg | JHHBAI Bulletin of the Johns Hopkins Hospital. 52 (1933),39. | ||
| 6. | ipr-rbt LDLo:100 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473. | ||
| 7. | scu-rbt LDLo:100 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473. | ||
| 8. | ivn-rbt LDLo:100 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473. | ||
| 9. | ims-rbt LDLo:135 mg/kg | AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 171 (1933),439. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or “jake.” This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-o-cresyl phosphate is more toxic than the m-form, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects.
Combustible when exposed to heat or flame. Can react with oxidizing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of POx. See also PHOSPHATES.
Standards and Recommendations
OSHA PEL: TWA 0.1 mg/m3 (skin)
ACGIH TLV: TWA 0.1 mg/m3 (skin); Not Classifiable as a Human Carcinogen
ACGIH TLV: TWA 0.1 mg/m3 (skin); Not Classifiable as a Human Carcinogen
Analytical Methods
For occupational chemical analysis use NIOSH: Triorthocresyl Phosphate, S209.