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Cas Database

Name	Tri-o-cresyl phosphate	EINECS	201-103-5
CAS No.	78-30-8	Density	1.2
PSA	54.57000	LogP	6.25670
Solubility	0.1mgl-1(e)	Melting Point	-25 °C
Formula	C21H21 O4 P	Boiling Point	410 °C
Molecular Weight	368.369	Flash Point	225 °C
Transport Information	N/A	Appearance	colorless viscous liquid.
Safety	Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or “jake.” This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-o-cresyl phosphate is more toxic than the m-form, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects. Combustible when exposed to heat or flame. Can react with oxidizing materials. To fight fire, use CO₂, dry chemical. When heated to decomposition it emits highly toxic fumes of PO_x. See also PHOSPHATES.
Analytical Methods:		For occupational chemical analysis use NIOSH: Triorthocresyl Phosphate, S209.	Risk Codes	51/53-39/23/24/25
Molecular Structure		Hazard Symbols	Toxic by ingestion and skin absorption. The o- isomer is highly toxic. TLV: 0.1 mg/m³ (skin); Not Classifiable as a Human Carcinogen.
Synonyms	Phosphoricacid, tri-o-tolyl ester (8CI); NSC 438; Phosflex 179C; TOCP; TOKF; TOTP;Tri-o-cresyl phosphate; Tri-o-tolyl phosphate; Tris(2-tolyl) phosphate;Tris(o-cresyl) phosphate; Tris(o-methylphenyl) phosphate; Tris(o-tolyl)phosphate; o-Cresyl phosphate	Article Data	19

Tri-o-cresyl phosphate Chemical Properties

MF: C₂₁H₂₁O₄P
MW: 368.36
mp: -25 °C
bp: 410 °C
density: 1.2
Fp: 225 °C
EINECS: 201-103-5
refractive index: 1.558-1.561
Appearane: colourless, odourless, non-volatile liquid
TRIORTHOCRESYL PHOSPHATE is miscible with most organic solvents,but not miscible with water. It is Combustible.

Tri-o-cresyl phosphate Uses

TRIORTHOCRESYL PHOSPHATE is commonly used as a plasticizer in many industrial processes.

Tri-o-cresyl phosphate Toxicity Data With Reference

1.	orl-rat LD50:1160 mg/kg	TOXID9 Toxicologist. 4 (1984),55.
2.	ipr-rat LD50:2500 mg/kg	APCRAW Advances in Pest Control Research. 4 (1961),117.
3.	scu-mus LDLo:12,500 mg/kg	EDWU** Beitrag zur Toxikologie Technischer Weichmachungsmittel, Heinrich Eller Dissertation .(Pharmakologischen Institut der Universitat Wurzburg,Germany.: 1937).
4.	scu-dog LDLo:100 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473.
5.	scu-cat LDLo:185 mg/kg	JHHBAI Bulletin of the Johns Hopkins Hospital. 52 (1933),39.
6.	ipr-rbt LDLo:100 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473.
7.	scu-rbt LDLo:100 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473.
8.	ivn-rbt LDLo:100 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 168 (1932),473.
9.	ims-rbt LDLo:135 mg/kg	AEPPAE Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 171 (1933),439.

Tri-o-cresyl phosphate Consensus Reports

Reported in EPA TSCA Inventory.

Tri-o-cresyl phosphate Safety Profile

Poison by subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Most of the cases of tri-o-cresyl phosphate poisoning have followed its ingestion. In 1930, some 15,000 persons were affected in the United States, and of these, 10 died. The responsible material was found to be an alcoholic drink known as Jamaica ginger, or “jake.” This beverage had been adulterated with about 2% of tri-o-cresyl phosphate. The affected persons developed a polyneuritis, which progressed, in many cases, with degeneration of the peripheral motor nerves, the anterior horn cells, and the pyramidal tracts. Sensory changes were absent. Since 1930 there have been several other outbreaks of poisoning following ingestion of the material. Tri-o-cresyl phosphate is more toxic than the m-form, and much more so than tri-p-cresyl phosphate or triphenyl phosphate. Experimental reproductive effects.

Combustible when exposed to heat or flame. Can react with oxidizing materials. To fight fire, use CO₂, dry chemical. When heated to decomposition it emits highly toxic fumes of PO_x. See also PHOSPHATES.

Tri-o-cresyl phosphate Standards and Recommendations

OSHA PEL: TWA 0.1 mg/m³ (skin)
ACGIH TLV: TWA 0.1 mg/m³ (skin); Not Classifiable as a Human Carcinogen

Tri-o-cresyl phosphate Analytical Methods

For occupational chemical analysis use NIOSH: Triorthocresyl Phosphate, S209.

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