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CAS No.: | 78415-72-2 |
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Name: | Milrinone |
Article Data: | 32 |
Molecular Structure: | |
Formula: | C12H9N3O |
Molecular Weight: | 211.223 |
Synonyms: | 6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;Milrinone,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;1,6-Dihydro-2-methyl-6-oxo(3,4-bipyridine)-5-carbonitrile;sodium sulfonate;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;(3,4-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-;Milrinona [Spanish];WIN 47203-2;Milrinone [USAN:BAN:INN];YM 018;Milrinonum [Latin];Win 47203;[3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro- 2-methyl-6-oxo-;Milrinone (JAN/USAN);Mirinone; |
EINECS: | 278-903-6 |
Density: | 1.288 g/cm3 |
Melting Point: | >3000C |
Boiling Point: | 448.685 °C at 760 mmHg |
Flash Point: | 225.157 °C |
Solubility: | DMSO: >10 mg/mL |
Appearance: | Crystalline solid |
Hazard Symbols: | T, T+ |
Risk Codes: | 23/24/25-26/27/28 |
Safety: | 36/37/39-45-22 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 69.54000 |
LogP: | 1.61698 |
Molecular Formula: C12H9N3O
Molecular Weight: 211.22
EINECS: 278-903-6
Index of Refraction: 1.622
Molar Refractivity: 57.76 cm3
Molar Volume: 164 cm3
Surface Tension: 60.2 dyne/cm
Density: 1.28 g/cm3
Flash Point: 225.2 °C
Enthalpy of Vaporization: 70.72 kJ/mol
Boiling Point: 448.7 °C at 760 mmHg
Vapour Pressure: 3.04E-08 mmHg at 25 °C
Storage tempreture: 2-8 °C
Solubility: DMSO: >10 mg/mL
Appearance: Off-white solid
Structure of Milrinone (CAS NO.78415-72-2):
IUPAC Name: 6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Canonical SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChIKey: PZRHRDRVRGEVNW-UHFFFAOYSA-N
Product Category of Milrinone (CAS NO.78415-72-2): Active Pharmaceutical Ingredients;API;Heterocycles;Intermediates & Fine Chemicals;Cyclic Nucleotide related
Milrinone (CAS NO.78415-72-2) is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient.
1. | orl-rat LD50:91 mg/kg | NCDREP New Cardiovascular Drugs. 3 (1985),245. | ||
2. | scu-rat LD50:58 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 27 (1996),652. | ||
3. | ivn-rat LD50:73 mg/kg | NCDREP New Cardiovascular Drugs. 3 (1985),245. | ||
4. | orl-mus LD50:137 mg/kg | NCDREP New Cardiovascular Drugs. 3 (1985),245. | ||
5. | scu-mus LD50:62 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 27 (1996),652. | ||
6. | ivn-mus LD50:79 mg/kg | NCDREP New Cardiovascular Drugs. 3 (1985),245. |
A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.
The Hazard Codes: T,T+
The Risk Statements information:
23/24/25: Toxic by inhalation, in contact with skin and if swallowed
26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
The Safety Statements information:
22: Do not breathe dust
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR: UN 2811 6.1/PG 3
Milrinone , its cas register number is 78415-72-2. It also can be called 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile ; Milrinonum ; and (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo- . It is a phosphodiesterase III inhibitor, and enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum.