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| CAS No.: | 79293-84-8 | ||||
|---|---|---|---|---|---|
| Name: | N-(TERT-BUTYLDIMETHYLSILYL)PHTHALIMIDE | ||||
| Molecular Structure: | |||||
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| Formula: | C14H19 N O2 Si | ||||
| Molecular Weight: | 261.396 | ||||
| Synonyms: | N-(TERT-BUTYLDIMETHYLSILYL)PHTHALIMIDE;N-(T-BUTYLDIMETHYLSILYL)PHTHALIMIDE | ||||
| Density: | 1.09g/cm3 | ||||
| Melting Point: |
115-119 °C(lit.) |
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| Boiling Point: | 336°C at 760 mmHg | ||||
| Flash Point: | 157°C | ||||
| Safety: |
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| PSA: | 37.38000 | ||||
| LogP: | 3.22570 | ||||

phthalimide


ketene t-butyldimethylsilyl methyl acetal


N-(tert-butyldimethylsilyl)phthalimide

| Conditions | Yield |
|---|---|
| In acetonitrile at 60℃; for 0.25h; | 77% |

phthalimide


tert-butyldimethylsilyl chloride


N-(tert-butyldimethylsilyl)phthalimide

| Conditions | Yield |
|---|---|
| With triethylamine In dichloromethane for 6h; Heating; | 71% |
| With triethylamine In dichloromethane at 20℃; for 4.5h; | 65% |

N-(trimethylsilyl)phthalimide


N-(tert-butyldimethylsilyl)phthalimide

| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: tetrahydrofuran / 20 °C 2: triethylamine / dichloromethane / 4.5 h / 20 °C View Scheme |

3-(2-bromoethyl)-4-(phenylsulfonyl)-1,2,5-oxadiazole


N-(tert-butyldimethylsilyl)phthalimide


2-{2-[4-(phenylsulfonyl)-1,2,5-oxadiazol-3-yl]ethyl}-1H-isoindole-1,3(2H)-dione

| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran for 3h; Heating; | 92% |

N-(tert-butyldimethylsilyl)phthalimide


methyl 2-[fluoro(phenyl)methyl]acrylate

| Conditions | Yield |
|---|---|
| With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 25℃; regioselective reaction; | 90% |

diethyl (bromomethyl)phosphonate


N-(tert-butyldimethylsilyl)phthalimide


diethyl (phthalimidomethyl)phosphonate

| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran for 12h; Heating; | 85% |

diethyl 2-bromoethylphosphonate


N-(tert-butyldimethylsilyl)phthalimide


[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)ethyl]phosphonic acid diethyl ester

| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran for 8h; Heating; | 84% |

N-(tert-butyldimethylsilyl)phthalimide


6-chloro-2-fluoro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

| Conditions | Yield |
|---|---|
| With cesium fluoride In N,N-dimethyl-formamide at 20℃; for 24h; | A 4% B 84% |
| With 4 A molecular sieve; tetrabutyl ammonium fluoride In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 24h; | A 19% B 57% |


diethyl 3-(bromopropyl)phosphonic acid


N-(tert-butyldimethylsilyl)phthalimide


[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)propyl]phosphonic acid diethyl ester

| Conditions | Yield |
|---|---|
| With tetrabutyl ammonium fluoride In tetrahydrofuran for 8h; Heating; | 79% |