CAS No.835-31-4,Naphazoline Suppliers

Products Categories

Pharmaceutical (64)
Organic Chemicals (9)
Others (6)
Agrochemicals (1)
Reagent (1)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	835-31-4
Name:	Naphazoline
Article Data:	17

Formula:	C₁₄H₁₅ClN₂
Molecular Weight:	210.279
Synonyms:	2-Imidazoline,2-(1-naphthylmethyl)- (7CI,8CI);Naphazoline (6CI);2-(1-Naphthalenylmethyl)-2-imidazoline;2-(1-Naphthylmethyl)-2-imidazoline;Antan;Antigaimorit;Colirio Alfa;Euboral Oftalmico;Imidin;Naphthazoline;Naphthizine;Rhinazine;
EINECS:	212-641-5
Density:	1.156 g/cm³
Melting Point:	254 °C
Boiling Point:	440.466 °C at 760 mmHg
Flash Point:	220.186 °C
Hazard Symbols:	T
Risk Codes:	25
Safety:	45
Transport Information:	UN 2811 6.1/PG 2
PSA:	24.39000
LogP:	2.14840

Synthetic route

: 86-87-3
naphth-1-yl acetic acid

: 107-15-3
ethylenediamine

: 835-31-4
naphazoline

Conditions

Conditions	Yield
for 2h; Time; Reflux;	85%
With iron oxide In water; benzene at 80℃; for 4h;	30%

: 132-75-2
naphthalen-1-ylacetonitrile

: 14034-59-4
ethylene diamine mono-p-toluenesulfonic acid salt

: 835-31-4
naphazoline

: 86-87-3
naphth-1-yl acetic acid

: 6780-13-8
1,2-ethanediamine monohydrate

: 835-31-4
naphazoline

Conditions

Conditions	Yield
With hydrogenchloride

: N-[1]naphthylacetyl-glycine nitrile

: 835-31-4
naphazoline

Conditions

Conditions	Yield
With ammonia; nickel; isopropyl alcohol at 70℃; under 73550.8 Torr; Hydrogenation.Erhitzen des Reaktionsprodukts unter vermindertem Druck;

: 132-75-2
naphthalen-1-ylacetonitrile

: 141-43-5
ethanolamine

: 835-31-4
naphazoline

Conditions

Conditions	Yield
With ammonium chloride; zinc(II) chloride

: 100621-70-3
ethyl-[1]naphthylethynyl ether

: 107-15-3
ethylenediamine

: 835-31-4
naphazoline

: 132-75-2
naphthalen-1-ylacetonitrile

ethylenediamine-mono hydrochloride: ethylenediamine-mono hydrochloride

: 835-31-4
naphazoline

: 68211-49-4
1-naphthyl tosylate

: 835-31-4
naphazoline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diethyl ether View Scheme

: 132-75-2
naphthalen-1-ylacetonitrile

: 107-15-3
ethylenediamine

: 835-31-4
naphazoline

Conditions

Conditions	Yield
With carbon disulfide at 110℃; for 2h; Reagent/catalyst; Temperature;

: 835-31-4
naphazoline

: 550-99-2
naphazoline hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In acetonitrile at 20℃; Solvent; Large scale;	92.33%
With hydrogenchloride In acetone at 5℃; for 0.5h; pH=1; Temperature; Reflux;

Total:73 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 835-31-4

Specification

The Naphazoline, with the CAS registry number 835-31-4, is also known as 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-. It belongs to the product category of API. Its EINECS registry number is 212-641-5. This chemical's molecular formula is C₁₄H₁₅ClN₂ and molecular weight is 246.74. What's more, its IUPAC name is called 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole. Naphazoline is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. This chemical acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion.

Physical properties about Naphazoline are: (1)ACD/LogP: 2.988; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.99; (4)ACD/LogD (pH 7.4): 1.04; (5)ACD/BCF (pH 5.5): 1.10; (6)ACD/BCF (pH 7.4): 1.25; (7)ACD/KOC (pH 5.5): 10.07; (8)ACD/KOC (pH 7.4): 11.40; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 24.39 Å²; (13)Index of Refraction: 1.64; (14)Molar Refractivity: 65.526 cm³; (15)Molar Volume: 181.848 cm³; (16)Polarizability: 25.976×10^-24 cm³; (17)Surface Tension: 44.63 dyne/cm; (18)Density: 1.156 g/cm³; (19)Flash Point: 220.186 °C; (20)Enthalpy of Vaporization: 67.071 kJ/mol; (21)Boiling Point: 440.466 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25 °C.

Uses of Naphazoline: it is used to produce other chemicals. For example, it can produce 2-(1-naphthylmethyl)imidazole. The reaction occurs with solvent toluene and other condition of heating for 200 hours. The yield is 83 %.

Naphazoline can produce 2-(1-naphthylmethyl)imidazole.

When you are dealing with this chemical, you should be very careful. This chemical may cause damage to health at low levels. It is toxic if swallowed. In case of accident or if you feel unwell you should seek medical advice immediately.

You can still convert the following datas into molecular structure:
(1) SMILES: N\1=C(\NCC/1)Cc2cccc3c2cccc3
(2) InChI: InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)
(3) InChIKey: CNIIGCLFLJGOGP-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LDLo	intravenous	10mg/kg (10mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 192, Pg. 141, 1939.
mouse	LD50	intraperitoneal	62mg/kg (62mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979.
mouse	LD50	intravenous	170mg/kg (170mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
mouse	LD50	oral	270mg/kg (270mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 729, 1979.
mouse	LD50	subcutaneous	514mg/kg (514mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Russian Pharmacology and Toxicology Vol. 37, Pg. 198, 1974.
rabbit	LD50	intravenous	800ug/kg (.8mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
rabbit	LD50	subcutaneous	950ug/kg (.95mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.
rat	LD50	subcutaneous	385mg/kg (385mg/kg)		Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 9, Pg. 280, 1950.