CAS No.89-01-0,2,3-Pyrazinedicarboxylic acid Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	89-01-0
Name:	2,3-Pyrazinedicarboxylic acid
Article Data:	24

Formula:	C₆H₄N₂O₄
Molecular Weight:	168.109
Synonyms:	2,3-Dicarboxypyrazine;NSC 1908;
EINECS:	201-875-3
Density:	1.665 g/cm³
Melting Point:	185-188 °C
Boiling Point:	449.1 °C at 760 mmHg
Flash Point:	225.4 °C
Solubility:	soluble in water
Appearance:	white to pale brown crystalline powder
Hazard Symbols:	F, C
Risk Codes:	36/37/38
Safety:	22-24/25-45-36/37/39-26-16
PSA:	100.38000
LogP:	-0.12700

Synthetic route

: 46150-15-6
pyrazine-2,3-dicarboxylatocopper(II)

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With water; sodium hydroxide at 90℃; for 2h;	73%

: 91-19-0
2,3-diethynylquinoxaline

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With potassium permanganate In water at 95℃;	71%
With potassium hydroxide; potassium permanganate
With water; permanganate(VII) ion

: 921-52-8
2,3-Diaminosuccinic acid

: 131543-46-9
Glyoxal

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With sodium hydroxide In methanol 1) 50 deg C, 30 min, 2) relux, 3h;	70%

polymer-bound 2,3-pyrazinedicarboxylic acid (19): polymer-bound 2,3-pyrazinedicarboxylic acid (19)

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water for 48h; Heating;	56.3%

: 13481-25-9
pyrazine-2,3-dicarbonitrile

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With potassium hydroxide; dihydrogen peroxide	40.3%
beim Verseifen;
With sodium peroxide
Multi-step reaction with 2 steps 1: methanol / 20 °C 2: water / Reflux View Scheme
Multi-step reaction with 5 steps 1: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 2: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 3: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 4: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 5: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 View Scheme

: 4744-50-7
2,3-pyrazinedicarboxylic anhydride

: 7732-18-5
water

: 89-01-0
2,3-dicarboxypyrazine

: 91-19-0
2,3-diethynylquinoxaline

potassium permanganate: potassium permanganate

alkali: alkali

: 89-01-0
2,3-dicarboxypyrazine

...Expand

: 66505-29-1
3-cyanopyrazine-2-carboxamide

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 2: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 3: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 4: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 View Scheme

: 70546-26-8
3-cyanopyrazine-2-carboxylic acid

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 2: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 3: K3Na[Mo(CN)4O2]·6H2O / ethanol; water / 39.84 °C / pH 8.5 View Scheme

: 67367-37-7
3-amidecarbonylpyrazine-2-carboxylic acid

: 89-01-0
2,3-dicarboxypyrazine

Conditions

Conditions	Yield
With K3Na[Mo(CN)4O2]·6H2O In ethanol; water at 39.84℃; pH=8.5;

Raw Materials

921-52-8

91-19-0

Downstream Products

338-70-5

290-37-9

6164-78-9

98-96-4

98-97-5

4744-50-7

6164-79-0

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Specification

The 2,3-Pyrazinedicarboxylicacid, with the CAS registry number 89-01-0, is also known as Pyrazine-2,3-dicarboxylic acid. It belongs to the product categories of Carboxylic Acids; Pyrazines, Pyrimidines & Pyridazines; Pyrazine; Organic acids; Pyrazines; Pyrazinecarboxylic Acid & Derivatives; Carboxylic Acids; Pyrazines, Pyrimidines & Pyridazines; Heterocycles; Building Blocks;Heterocyclic Building Blocks. Its EINECS registry number is 201-875-3. This chemical's molecular formula is C₆H₄N₂O₄ and molecular weight is 168.11. Its IUPAC name is called pyrazine-2,3-dicarboxylic acid. The product can be used as an intermediate of anti-TB drugs pyrazinamide.

Physical properties of 2,3-Pyrazinedicarboxylicacid: (1)ACD/LogP: -3.20; (2)ACD/LogD (pH 5.5): -6.94; (3)ACD/LogD (pH 7.4): -7.34; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 6; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.638; (12)Molar Refractivity: 36.29 cm³; (13)Molar Volume: 100.9 cm³; (14)Surface Tension: 100.7 dyne/cm; (15)Density: 1.665 g/cm³; (16)Flash Point: 225.4 °C; (17)Enthalpy of Vaporization: 74.58 kJ/mol; (18)Boiling Point: 449.1 °C at 760 mmHg; (19)Vapour Pressure: 7.51E-09 mmHg at 25°C.

Preparation: this chemical can be prepared by benzo pyrazine. This reaction will need reagent potassium permanganate and hydrochloric acid. The yield is about 70%.

Uses of 2,3-Pyrazinedicarboxylicacid: it can be used to produce pyrazine-2,3-dicarboxylic acid dimethyl ester. This reaction will need reagent concentrated H₂SO₄.

When you are using this chemical, please be cautious about it as the following:
This chemical may catch fire in contact with air and only need brief contact with an ignition source which has a very low flash point or evolve highly flammable gases in contact with water. Besides, it may destroy living tissue on contact. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CN=C(C(=N1)C(=O)O)C(=O)O
(2)InChI: InChI=1S/C6H4N2O4/c9-5(10)3-4(6(11)12)8-2-1-7-3/h1-2H,(H,9,10)(H,11,12)
(3)InChIKey: ZUCRGHABDDWQPY-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LDLo	oral	> 500mg/kg (500mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 7, 1953.