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CAS No.: | 4744-50-7 |
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Name: | 2,3-Pyrazinecarboxylic anhydride |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C6H2N2O3 |
Molecular Weight: | 150.093 |
Synonyms: | 2,3-Pyrazinedicarboxylicanhydride (6CI,7CI,8CI);2,3-Pyrazinedicarboxylic acid anhydride;Furano[3,4-b]pyrazine-5,7-dione; |
EINECS: | 225-260-4 |
Density: | 1.686 g/cm3 |
Melting Point: | 210 °C (dec.)(lit.) |
Boiling Point: | 357.3 °C at 760 mmHg |
Flash Point: | 169.9 °C |
Appearance: | white of off-white power |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 69.15000 |
LogP: | -0.21280 |
Conditions | Yield |
---|---|
With acetic anhydride for 0.0833333h; | 94% |
With acetic anhydride Heating; | 93% |
With acetic anhydride for 0.166667h; Heating; | 83% |
Conditions | Yield |
---|---|
for 1h; Reflux; | 70% |
Conditions | Yield |
---|---|
(i) KMnO4, (ii) Ac2O; Multistep reaction; |
methanol
2,3-pyrazinedicarboxylic anhydride
3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid
Conditions | Yield |
---|---|
for 12h; Ambient temperature; | 100% |
at 20℃; for 72h; | 75% |
acetamide
2,3-pyrazinedicarboxylic anhydride
N-acetylpyrazine-2-carboxamide
Conditions | Yield |
---|---|
for 4h; Reflux; | 100% |
5-chloro-2-pyridylamine
2,3-pyrazinedicarboxylic anhydride
3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1h; | 99% |
In tetrahydrofuran at 20℃; for 1h; | 99% |
In dichloromethane at 5 - 20℃; for 3.5h; Product distribution / selectivity; | |
Stage #1: 5-chloro-2-pyridylamine; 2,3-pyrazinedicarboxylic anhydride In toluene at 20 - 52℃; for 2.5h; Stage #2: With hydrogenchloride In water at 10 - 15℃; for 1h; |
2,3-pyrazinedicarboxylic anhydride
4-amino-2,5-dimethoxy-N-phenylbenzamide
N-(2,5-dimethoxy-4-(phenylcarbamoyl)phenyl)pyrazine-2-carboxamide
Conditions | Yield |
---|---|
In toluene for 12h; Inert atmosphere; Reflux; | 99% |
2,3-pyrazinedicarboxylic anhydride
1-Adamantanamine
N-((3s,5s,7s)-adamantan-1-yl)pyrazine-2-carboxamide
Conditions | Yield |
---|---|
In toluene for 12h; Inert atmosphere; Reflux; | 99% |
Conditions | Yield |
---|---|
In toluene for 12h; Inert atmosphere; Reflux; | 99% |
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 18h; | 98% |
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The Furo[3,4-b]pyrazine-5,7-dione, with CAS registry number 4744-50-7, belongs to the following product categories: (1)Glycinescaffold; (2)Fused Ring Systems. It has the systematic name of furo[3,4-b]pyrazine-5,7-dione. And the chemical formula of this chemical is C6H2N2O3. What's more, its EINECS is 225-260-4.
Physical properties of Furo[3,4-b]pyrazine-5,7-dione: (1)ACD/LogP: -0.90; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.9; (4)ACD/LogD (pH 7.4): -0.9; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 7.74; (8)ACD/KOC (pH 7.4): 7.74; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 69.15 Å2; (13)Index of Refraction: 1.634; (14)Molar Refractivity: 31.86 cm3; (15)Molar Volume: 89 cm3; (16)Polarizability: 12.63×10-24cm3; (17)Surface Tension: 90 dyne/cm; (18)Density: 1.686 g/cm3; (19)Flash Point: 169.9 °C; (20)Enthalpy of Vaporization: 60.26 kJ/mol; (21)Boiling Point: 357.3 °C at 760 mmHg; (22)Vapour Pressure: 2.76E-05 mmHg at 25°C.
Preparation: this chemical can be prepared by pyrazine-2,3-dicarboxylic acid. This reaction will need reagent thionyl chloride.
When you are using this chemical, please be cautious about it as the following:
The Furo[3,4-b]pyrazine-5,7-dione irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C1OC(=O)c2nccnc12
(2)InChI: InChI=1/C6H2N2O3/c9-5-3-4(6(10)11-5)8-2-1-7-3/h1-2H
(3)InChIKey: AWJWCTOOIBYHON-UHFFFAOYAK
(4)Std. InChI: InChI=1S/C6H2N2O3/c9-5-3-4(6(10)11-5)8-2-1-7-3/h1-2H
(5)Std. InChIKey: AWJWCTOOIBYHON-UHFFFAOYSA-N