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964-21-6

Basic Information
CAS No.: 964-21-6
Name: O6-METHYL-2'-DEOXYGUANOSINE
Article Data: 16
Molecular Structure:
Molecular Structure of 964-21-6 (O6-METHYL-2'-DEOXYGUANOSINE)
Formula: C11H15 N5 O4
Molecular Weight: 281.271
Synonyms: 9H-Purine,2-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)-6-methoxy- (8CI); 9H-Purine,2-amino-9-(2-deoxy-b-D-ribofuranosyl)-6-methoxy- (7CI); 2-Amino-6-methoxy-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine;2'-Deoxy-6-methylguanosine; 6-O-Methyl-2'-deoxyguanosine;6-O-Methyldeoxyguanosine; O6-Methyl-2'-deoxyguanosine; O6-Methyldeoxyguanosine
Density: 1.84 g/cm3
Boiling Point: 674.7 °C at 760 mmHg
Flash Point: 361.9 °C
PSA: 128.54000
LogP: -0.36100
Synthetic route
82921-45-7

2'-deoxy-N2-isobutyryl-O6-methylguanosine

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
With ammonium hydroxide at 50℃; for 72h;100%
With potassium hydroxide for 8h; Ambient temperature;99%
With potassium hydroxide at 22℃; Rate constant;
128790-76-1

2-N-trifluoroacetamido-6-pentafluorophenoxy-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine

124-41-4

sodium methylate

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
In methanol at 55℃; for 36h;85%

2-amino-9-[2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythto-pentofuranosyl]-6-methoxy-9-H-purine

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
With sodium methylate In methanol for 1h;76%
124-41-4

sodium methylate

69992-11-6

2-amino-6-chloro-9-[(3’,5’-di-O-acetyl-2’-deoxy)-β-D-ribofuranosyl]purine

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
In methanol at 0 - 20℃; for 6h; Inert atmosphere;69%
142738-49-6

(2R,3S,5R)-5-(2-Amino-6-methoxy-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 0.166667h;54%
705255-09-0

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-(imidazol-1-yl)purine

67-56-1

methanol

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
With Dowex 1 x 2 (OH-) resin at 20℃;52%
17287-03-5

trimethylsulphonium hydroxide

961-07-9

2'-Deoxyguanosine

A

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

B

5132-79-6

N1-methyl-2'-deoxyguanosine

C

107149-64-4

2'-deoxy-7-methylguanosine

D

76551-24-1

9-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-methyl-2-methylamino-1,9-dihydro-purin-6-one

Conditions
ConditionsYield
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Further byproducts given;A 6 mg
B 23%
C n/a
D 7 mg
In methanol; N,N-dimethyl-formamide at 70℃; for 1h; Further byproducts given;A 6 mg
B 19 mg
C n/a
D 7 mg
124-41-4

sodium methylate

961-07-9

2'-Deoxyguanosine

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Conditions
ConditionsYield
With pyridine; trifluoroacetic anhydride 1. ice bath, 10 min, 2. methanol, 24 h; Yield given. Multistep reaction;
684-93-5

1-methyl-1-nitrosourea

961-07-9

2'-Deoxyguanosine

A

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

B

5132-79-6

N1-methyl-2'-deoxyguanosine

C

812-00-0

methylphosphate

D

813-78-5

dimethylphosphoric acid

E

578-76-7

7-methylguanine

F

28074-91-1

N7-Me-dGuo

Conditions
ConditionsYield
With sodium hydroxide; phosphate buffer In methanol; water at 37℃; Product distribution; various pH values;
302584-95-8

N2-phenylacetyl-O6-methoxycarbonylmethyl-2'-deoxyguanosine

A

964-21-6

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

B

189457-83-8

[2-Amino-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-yloxy]-acetic acid methyl ester

C

O6-carboxymethyl-2'-deoxyguanosine

D

N2-phenylacetyl-O6-carboxymethyl-2'-deoxyguanosine

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; Product distribution; Further Variations:; Reagents; Hydrolysis;
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