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CAS No.: | 99-07-0 |
---|---|
Name: | 3-Dimethylaminophenol |
Article Data: | 39 |
Molecular Structure: | |
Formula: | C8H11NO |
Molecular Weight: | 137.181 |
Synonyms: | Phenol,m-(dimethylamino)- (6CI,7CI,8CI);(3-Hydroxyphenyl)dimethylamine;3-(Dimethylamino)phenol;3-Hydroxy-N,N-dimethylaniline;3-N,N-Dimethylaminophenol;N,N-Dimethyl-m-aminophenol;NSC 62017;m-(Dimethylamino)phenol;m-(N,N-Dimethylamino)phenol; |
EINECS: | 202-727-0 |
Density: | 1.089 g/cm3 |
Melting Point: | 82-84 °C(lit.) |
Boiling Point: | 266.5 °C at 760 mmHg |
Flash Point: | 132.7 °C |
Solubility: | slightly soluble in water |
Appearance: | brown to purple solid |
Hazard Symbols: | Xi,Xn |
Risk Codes: | 26-36-36/37/39-22 |
Safety: | 26-36-36/37/39-22 |
PSA: | 23.47000 |
LogP: | 1.45820 |
3-methoxy-N,N-dimethylaniline
3-Dimethylaminophenol
Conditions | Yield |
---|---|
With boron trichloride; tetra-(n-butyl)ammonium iodide In dichloromethane at -78 - 0℃; for 1h; dealkylation; | 95% |
Conditions | Yield |
---|---|
With hydrogen In water at 200℃; under 375.038 Torr; for 3h; Reagent/catalyst; Autoclave; | 93% |
Conditions | Yield |
---|---|
With copper(l) iodide; 6,7-dihydro-5H-quinolin-8-one oxime; potassium hydroxide In water at 25℃; for 24h; Inert atmosphere; | 91% |
methanesulfonic acid 3-dimethylaminophenyl ester
3-Dimethylaminophenol
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at 0℃; for 0.0166667h; | 89% |
Conditions | Yield |
---|---|
With copper(l) iodide; 6,7-dihydro-5H-quinolin-8-one oxime; potassium hydroxide In water at 85℃; for 24h; Inert atmosphere; | 89% |
3-Dimethylaminophenol
Conditions | Yield |
---|---|
In water-d2 for 0.5h; Inert atmosphere; Photolysis; | 89% |
N,N-dimethyl-aniline
A
4-(N,N-dimethylamino)phenol
B
2-hydroxy-N,N-dimethylaniline
C
3-Dimethylaminophenol
Conditions | Yield |
---|---|
With dihydrogen peroxide; antimony pentafluoride In hydrogen fluoride at -20℃; for 0.25h; Mechanism; Product distribution; | A 26% B 14% C 44% |
With hydrogen fluoride; dihydrogen peroxide; antimony pentafluoride at -20℃; for 0.25h; | A 26% B 14% C 44% |
With dihydrogen peroxide; antimony pentafluoride In hydrogen fluoride at -20℃; for 0.25h; | A 26% B 14% C 44% |
Conditions | Yield |
---|---|
With hydrogen In methanol at 180℃; under 12751.3 Torr; for 8h; Autoclave; | 21% |
With sodium tetrahydroborate In methanol at 20℃; |
Conditions | Yield |
---|---|
at 170℃; |
Conditions | Yield |
---|---|
With potassium hydroxide |
IUPAC Name: 3-(dimethylamino)phenol
Molecular Formula: C8H11NO
Formula Weight: 137.18g/mol
Appearance: gray powder
Density: 1.089 g/cm3
Melting Point: 82 - 84 °C
Boiling Point: 266.5 °C at 760 mmHg
Refractive index: 1.589
Flash point: 132.7 °C
Vapor Pressure: 0.00524 mmHg at 25°C
Solubility: dissolved in ethanol, ether, benzene, acetone, alkali, and inorganic acid,not almost soluble in water
EINECS: 202-727-0
liansport Information: 70kgs
Freely Rotating Bonds: 2
Molar Refractivity: 42.44 cm3
Molar Volume: 125.8 cm3
Polarizability: 16.82 10-24cm3
Surface Tension: 44 dyne/cm
Enthalpy of Vaporization: 52.48 kJ/mol
Sensitive: Light Sensitive
The chemical synonyms of 3-Dimethylaminophenol (CAS NO.99-07-0) are (3-Hydroxyphenyl)dimethylamine;3-(dimethylamino)-pheno;3-Hydroxydimethylaminobenzene;3-Hydroxy-N,N-dimethylaniline and 3-n,n-dimethylaminophenol.Its product categories is benzene derivative;Aromatic Phenols;Phenoles and thiophenoles;Amines;Aromatics and Pharmaceutical Intermediate.The molecular structure of 3-Dimethylaminophenol (CAS NO.99-07-0) is.
It can be used as neostigmine bromide intermediate and dye intermediate.
It is derived by the Inter-amino-phenol reaction with dimethyl sulfate.
1. | mma-sat 33 µg/plate | EMMUEG Environmental and Molecular Mutagenesis. 11 (Suppl 12)(1988),1. |
Reported in EPA TSCA Inventory.
Mutation data reported. When heated to decomposition it emits toxic vapors of NOx.
Hazard Codes: Xi,Xn .
Xn: Harmful
Xi: Irritant
Risk Statements: 36/37/38-20/21/22 .
20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-36/37/39-22.
22: Do not breathe dust.
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36: Wear suitable protective clothing.
36/37/39: Wear suitable protective clothing, gloves and eye/face protection.