116412-83-0Relevant articles and documents
Gold-based immunochromatographic strip assay for detecting dimethomorph in vegetables
Kuang, Hua,Liu, Liqiang,Xiang, Tongyue,Xu, Chuanlai,Xu, Liguang,Xu, Xinxin
, p. 3882 - 3888 (2022/03/07)
Dimethomorph (DMM) is a novel therapeutic fungicide, which is mainly used to control downy mildew, phytophthora, and other fungal diseases of grapes, leeks, and cucumbers. Its residue is harmful to the human body and the soil environment. In this study, the optimum monoclonal antibody (mAb) against DMM was prepared after routine fusion and selection. Based on the mAb, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and a gold nanoparticle immunochromatographic assay (GNP-ICA) were developed for detecting DMM in leek samples. The 50% inhibitory concentration (IC50) of the mAb was 1.823 ng mL-1, and its cross-reactivity with structurally related analogs was less than 3%. Under optimal conditions, the visible detection limit of this ICA method was 10 ng g-1, and the cutoff value of DMM in leeks was 100 ng g-1. The analysis of DMM in leeks showed that the results of the strip analysis were highly comparable with those of ic-ELISA and liquid chromatography-mass spectrometry LC-MS. Therefore, the GNP immunoassay is a sensitive screening method for detecting DMM residues in foods.
Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution
Holmberg-Douglas, Natalie,Nicewicz, David A.
supporting information, p. 7114 - 7118 (2019/09/07)
Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.
Dimethomorph production method
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Paragraph 0011; 0012; 0013, (2018/06/15)
The invention discloses a dimethomorph production method in the technical field of pesticide production. The production method comprises: 1) synthesizing veratrole; 2) synthesizing 3,4-dimethoxy-4-chloro-benzophenone; 3) synthesizing acetylmorpholine; and 4) synthesizing dimethomorph. Sodium tert-butoxide is taken as a basic catalyst for synthesizing dimethomorph from 3,4-dimethoxy-4-chloro-benzophenone and acetylmorpholine, and a sodium hydroxide solution is used to perform alkali washing on a reactant in a reaction vessel. Sodium hydroxide has a catalytic effect on synthesis of dimethomorphfrom 3,4-dimethoxy-4-chloro-benzophenone and acetylmorpholine. The defect that the catalytic effect of sodium tert-butoxide is gradually reduced due to unstable chemical property of sodium tert-butoxide and degradation of sodium tert-butoxide when sodium tert-butoxide comes into water is overcome. The dimethomorph product is improved in conversion rate and purity.