138750-31-9Relevant articles and documents
Asymmetric Hydrogenation of β-Secondary Amino Ketones Catalyzed by a Ruthenocenyl Phosphino-oxazoline-ruthenium Complex (RuPHOX-Ru): The Synthesis of γ-Secondary Amino Alcohols
Wang, Jianxia,Wang, Yanzhao,Liu, Delong,Zhang, Wanbin
, p. 3262 - 3272 (2015/11/03)
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX-Ru) was applied successfully to the asymmetric hydrogenation of β-secondary amino ketones, directly affording the corresponding chiral γ-secondary amino alcohols in up to 99% yield and with 99% ee. Reaction with β-(benzylamino)-1-phenylpropan-1-one could be performed on a gram-scale with a relatively low catalyst loading (up to 2000 S/C). The resulting hydrogenated product could be used for the synthesis of synthetically useful compounds.
Synthesis and catalytic properties of 4-aryl-2,3-dihydro-4 H -pyrimido[2,3- b ]benzothiazoles for asymmetric acyl or carboxyl group transfer reactions
Viswambharan, Baby,Okimura, Tatsuya,Suzuki, Satoko,Okamoto, Sentaro
experimental part, p. 6678 - 6685 (2011/10/09)
4-Aryl-2,3-dihydro-4H-pyrimido[2,3-b]benzothiazoles (4-Ar-DHPBs) were synthesized and their catalytic activity and selectivity in kinetic resolution of a secondary alcohol as well as in the Steglich rearrangement and related reactions were evaluated. 4-Aryl-DHPBs showed low enantioselectivity in the acylative kinetic resolution of 1-phenylethanol. Conversely, they catalyzed the Steglich rearrangement with moderate to excellent enantioselectivity, demonstrating the possibility for remote stereocontrol by introduction of a substituent at the 4-position of DHPB.
TREATMENT OF METABOLIC SYNDROME WITH NOVEL AMIDES
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Page/Page column 83-84, (2009/07/17)
The present invention relates to the treatment of metabolic syndrome or disorders associated with metabolic syndrome comprising administering a compound of the invention.