152533-47-6 Usage
Description
(1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate is a complex organic compound with a unique molecular structure. It is characterized by its bicyclic ring system and the presence of a carboxylate group, which contributes to its reactivity and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate is used as a key intermediate in the synthesis of epiboxidine enantiomers and analogs. These compounds exhibit high binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors, making them valuable for the development of novel therapeutic agents targeting neurological disorders and cognitive enhancement.
Used in Chemical Synthesis:
In the field of organic chemistry, (1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate can be employed as a versatile building block for the preparation of various complex molecules. Its unique structure and reactivity make it a valuable tool for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and advanced materials.
Used in Research and Development:
Due to its structural complexity and potential applications, (1R,4S)-tert-butyl 2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate is also used in research and development settings. Scientists and chemists can utilize this compound to explore new reaction pathways, develop innovative synthetic methods, and gain a deeper understanding of the underlying chemical principles governing its reactivity and behavior.
Check Digit Verification of cas no
The CAS Registry Mumber 152533-47-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,2,5,3 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 152533-47:
(8*1)+(7*5)+(6*2)+(5*5)+(4*3)+(3*3)+(2*4)+(1*7)=116
116 % 10 = 6
So 152533-47-6 is a valid CAS Registry Number.
152533-47-6Relevant articles and documents
A short and efficient total synthesis of (±)-epibatidine
Zhang, Chunming,Trudell, Mark L.
, p. 7189 - 7191 (1996)
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Substituted Imidazopyridines as HDM2 Inhibitors
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Paragraph 0761, (2014/07/08)
The present invention provides substituted imidazopyridines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues
Wei, Zhi-Liang,Petukhov, Pavel A.,Xiao, Yingxian,Tückmantel, Werner,George, Clifford,Kellar, Kenneth J.,Kozikowski, Alan P.
, p. 921 - 924 (2007/10/03)
Conformationally constrained epibatidine analogues 20a,b and 23a,b were synthesized using a radical cyclization as the key step. Radioligand displacement assays to six defined rat nicotinic acetylcholine receptor (nAChR) subtypes showed that 20a,b bind with moderate affinities, while 23a,b have low affinities. 20a exhibits higher affinity for the β2 containing subtype than for the β4 containing counterpart, while 20b possesses reversed selectivity. Modeling studies suggest that the spatial distribution of the ligand's atoms around the pharmacophore elements may control their nAChR subtype selectivity.