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160060-21-9

160060-21-9

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160060-21-9 Usage

General Description

4-Thiazolecarboxylicacid,2-acetyl-,ethylester(9CI) is a chemical compound with the molecular formula C9H9NO2S. It is an ethyl ester derivative of 2-acetyl-4-thiazolecarboxylic acid, a heterocyclic compound containing a thiazole ring. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various drug molecules. It has also been studied for its potential bioactivity, particularly as an anti-inflammatory and antimicrobial agent. Its molecular structure and functional groups make it a versatile intermediate in organic synthesis, with potential applications in drug discovery and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 160060-21-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,0,6 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 160060-21:
(8*1)+(7*6)+(6*0)+(5*0)+(4*6)+(3*0)+(2*2)+(1*1)=79
79 % 10 = 9
So 160060-21-9 is a valid CAS Registry Number.

160060-21-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-acetyl-1,3-thiazole-4-carboxylate

1.2 Other means of identification

Product number -
Other names 2-acetyl-4-ethoxycarbonylthiazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:160060-21-9 SDS

160060-21-9Relevant articles and documents

TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES

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Paragraph 0014; 00307, (2020/07/14)

Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with cancer, including tubulysins and protein (e.g., antibody) drug conjugates thereof.

Synthesis method of 2-acetyl thiazole-4-ethyl formate

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Paragraph 0023; 0025-0030; 0041-0044; 0049-0056, (2017/11/04)

The invention discloses a synthesis method of 2-acetyl thiazole-4-ethyl formate. The method comprises the following steps: (1) adding L-cysteine ethyl ester hydrochloride, a methylglyoxal water solution, inorganic base and a phase transfer catalyst into a solvent system under nitrogen protection for carrying out a cyclization reaction; (2) separating an organic phase out of reaction products obtained in the step (1) under nitrogen protection, and mixing the organic phase with manganese dioxide for carrying out an oxidizing reaction; (3) purifying the product obtained in the step (2) to obtain the 2-acetyl thiazole-4-ethyl formate. The synthesis method provided by the invention is simple to operate, high in yield and low in cost.

Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of tubulysin-U

Shankar, P. Sreejith,Bigotti, Serena,Lazzari, Paolo,Manca, Ilaria,Spiga, Marco,Sani, Monica,Zanda, Matteo

, p. 6137 - 6141 (2013/10/22)

Tubulysins are potent anti-mitotic natural compounds and a scalable and efficient synthetic route for generation of its analogues has been developed and extended to the synthesis of diastereoisomers and N-terminal analogues of tubulysin-U. Structure-activ

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