1630-62-2 Usage
Description
(2R)-3-methyl-2-phenyl-1,3-oxazolidine is a chiral heterocyclic organic compound with the molecular formula C10H13NO. It belongs to the oxazolidine family and features a stereocenter at the second carbon atom, leading to two enantiomers, (2R) and (2S). (2R)-3-methyl-2-phenyl-1,3-oxazolidine has been studied for its potential biological activities, such as serving as a chiral ligand in asymmetric catalysis and exhibiting anti-inflammatory properties. It holds significance in medicinal chemistry and pharmaceutical research, where its properties and potential applications are being actively explored.
Uses
Used in Pharmaceutical Research:
(2R)-3-methyl-2-phenyl-1,3-oxazolidine is used as a chiral ligand in asymmetric catalysis for the development of enantioselective synthetic routes to produce biologically active compounds. Its unique stereochemistry allows for the creation of molecules with specific spatial arrangements, which is crucial for their interaction with biological targets and can lead to more effective drugs with fewer side effects.
Used in Medicinal Chemistry:
(2R)-3-methyl-2-phenyl-1,3-oxazolidine is utilized in the design and synthesis of novel pharmaceutical agents, particularly those with anti-inflammatory properties. Its structure can be modified to create derivatives with potential therapeutic applications, offering a versatile platform for the development of new medications to treat various inflammatory conditions.
Used in Chemical Synthesis:
(2R)-3-methyl-2-phenyl-1,3-oxazolidine is employed as an intermediate in the synthesis of complex organic molecules, including those with potential applications in materials science, agrochemicals, and other specialty chemical industries. Its unique structural features make it a valuable building block for creating innovative and high-performance compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1630-62-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1630-62:
(6*1)+(5*6)+(4*3)+(3*0)+(2*6)+(1*2)=62
62 % 10 = 2
So 1630-62-2 is a valid CAS Registry Number.
1630-62-2Relevant articles and documents
Atom-efficient transition-metal-free arylation ofN,O-acetals using diarylzinc reagents through Zn/Zn cooperativity
Borys, Andryj M.,Gil-Negrete, Jose M.,Hevia, Eva
supporting information, p. 8905 - 8908 (2021/09/10)
Exploiting the cooperative action of Lewis acid Zn(C6F5)2with diarylzinc reagents, the efficient arylation ofN,O-acetals to access diarylmethylamines is reported. Reactions take place under mild reaction conditions without the need for transtion-metal catalysis. Mechanistic investigations have revealed that Zn(C6F5)2not only acts as a Lewis acid activator, but also enables the regeneration of nucleophilic ZnAr2species, allowing a limiting 50 mol% to be employed.
Electrooxidative cyclization of hydroxyamino compounds possessing a benzyl group
Okimoto, Mitsuhiro,Ohashi, Kousuke,Yamamori, Haruki,Nishikawa, Shinnosuke,Hoshi, Masayuki,Yoshida, Takashi
experimental part, p. 1315 - 1322 (2012/06/30)
Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2- piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base. Georg Thieme Verlag Stuttgart · New York.
Heterogeneous rhodium-catalyzed hydrogenation conditions for the highly effective synthesis of 1,3-oxazolidines from 1,2-amino alcohols and nitriles
Letinois, Stephane,Dumur, Jean-Christophe,Henin, Francoise,Muzart, Jacques
, p. 2327 - 2330 (2007/10/03)
A procedure easily to carried out for the synthesis of 1,3-oxazolidines in high yields using 1,2-amino alcohols, nitriles, an atmospheric pressure of hydrogen and catalytic quantities of rhodium on carbon powder is presented. This reaction probably involves the semi-hydrogenation of the nitrile followed by condensation with the amine alcohol. The process may constitute the key step in a two-step sequence for reducing a nitrile into the corresponding aldehyde.
