181123-11-5 Usage
Description
5-Chloro-3-nitropyridine-2-carbonitrile is a chemical compound characterized by the molecular formula C7H2ClN3O2. It is a yellow crystalline solid that exhibits solubility in organic solvents. 5-Chloro-3-nitropyridine-2-carbonitrile is distinguished by its unique structure, which makes it a valuable building block in the synthesis of various products, including pharmaceuticals, agrochemicals, and specialty chemicals. Its versatility and potential applications in material science and functional molecule development underscore its importance in the chemical industry.
Uses
Used in Pharmaceutical Industry:
5-Chloro-3-nitropyridine-2-carbonitrile is utilized as a key building block for the synthesis of pharmaceuticals. Its unique structure contributes to the development of new drugs, enhancing the range of therapeutic options available for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-3-nitropyridine-2-carbonitrile serves as a crucial intermediate in the production of pesticides and other agricultural chemicals. Its role in these applications helps to improve crop protection and yield.
Used in Specialty Chemicals:
5-Chloro-3-nitropyridine-2-carbonitrile is employed as a building block in the synthesis of specialty chemicals, which are used in a wide range of applications, from coatings and adhesives to advanced materials for various industries.
Used in Dye and Pigment Production:
5-Chloro-3-nitropyridine-2-carbonitrile is also used as an intermediate in the production of dyes and pigments, contributing to the coloration and performance of these products in different applications, such as textiles, plastics, and printing inks.
Used in Electronic and Semiconductor Materials:
5-Chloro-3-nitropyridine-2-carbonitrile plays a role in the manufacturing of electronic and semiconductor materials, where its properties can be leveraged to improve the performance and functionality of these high-tech components.
It is essential to handle 5-Chloro-3-nitropyridine-2-carbonitrile with care due to its potential hazardous properties. Proper safety precautions should be strictly followed during its use to ensure the well-being of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 181123-11-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,1,2 and 3 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 181123-11:
(8*1)+(7*8)+(6*1)+(5*1)+(4*2)+(3*3)+(2*1)+(1*1)=95
95 % 10 = 5
So 181123-11-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H2ClN3O2/c7-4-1-6(10(11)12)5(2-8)9-3-4/h1,3H
181123-11-5Relevant articles and documents
NEW 6-MEMBERED HETEROAROMATIC SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS
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Page/Page column 318, (2017/09/24)
The present invention relates to pharmaceutical agents of formula (I), useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-KB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
HETEROARYL SULFONAMIDES AND CCR2
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Page/Page column 173-174, (2008/06/13)
Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, and as controls in assays for the identification of CCR2 antagonists.
Synthesis and SAR of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one as NMDA/glycine site antagonists
Zhou, Zhang-Lin,Navratil, James M.,Cai, Sui Xiong,Whittemore, Edward R.,Espitia, Stephen A.,Hawkinson, Jon E.,Tran, Minhtam,Woodward, Richard M.,Weber, Eckard,Keana, John F.W.
, p. 2061 - 2071 (2007/10/03)
A series of 5-, 6-, 7- and 8-aza analogues of 3-aryl-4-hydroxyquinolin-2(1H)-one was synthesized and assayed as NMDA/glycine receptor antagonists. The in vitro potency of these antagonists was determined by displacement of the glycine site radioligand [3H]5,7-dicholorokynurenic acid ([3H]DCKA) in rat brain cortical membranes. Selected compounds were also tested for functional antagonism using electrophysiological assays in Xenopus oocytes expressing cloned NMDA receptor (NR) 1A/2C subunits. Among the 5-, 6-, 7-, and 8-aza-3-aryl-4-hydroxyquinoline-2(1H)-ones investigated, 5-aza-7-chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2-(1H)-one (13i) is the most potent antagonist, having an IC50 value of 110 nM in [3H]DCKA binding and a Kb of 11 nM in the electrophysiology assay. Compound 13i is also an active anticonvulsant when administered systemically in the mouse maximum electroshock-induced seizure test (ED50 = 2.3 mg/kg, IP).
