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185346-79-6

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185346-79-6 Usage

Description

4-(Benzyloxy)-1-bromo-2-fluorobenzene is a chemical compound with the molecular formula C13H10BrFO. It is a substituted benzene derivative characterized by the presence of a bromine atom at the 1 position, a fluorine atom at the 2 position, and a benzyloxy group at the 4 position. This unique structure endows the molecule with versatility for use in synthetic and medicinal chemistry, making it a valuable building block for the development of biologically active molecules.

Uses

Used in Pharmaceutical Research:
4-(Benzyloxy)-1-bromo-2-fluorobenzene is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features allow for the creation of novel drug candidates with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(Benzyloxy)-1-bromo-2-fluorobenzene serves as a versatile building block for the preparation of a wide range of organic molecules. Its presence of a bromine and fluorine atom, along with the benzyloxy group, enables various synthetic transformations, facilitating the synthesis of complex organic molecules with diverse functional groups.
Used in Medicinal Chemistry:
4-(Benzyloxy)-1-bromo-2-fluorobenzene is utilized as a starting material in the design and synthesis of new bioactive molecules for medicinal chemistry research. Its unique structural elements can be further modified to explore novel chemical space and identify potential drug candidates with improved pharmacological properties.
Used in Chemical Libraries:
4-(Benzyloxy)-1-bromo-2-fluorobenzene can be incorporated into chemical libraries for high-throughput screening in drug discovery. Its unique structural features can contribute to the diversity of the library, increasing the chances of identifying new lead compounds with potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 185346-79-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,3,4 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 185346-79:
(8*1)+(7*8)+(6*5)+(5*3)+(4*4)+(3*6)+(2*7)+(1*9)=166
166 % 10 = 6
So 185346-79-6 is a valid CAS Registry Number.

185346-79-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H30053)  4-Benzyloxy-1-bromo-2-fluorobenzene, 98%   

  • 185346-79-6

  • 5g

  • 411.0CNY

  • Detail
  • Alfa Aesar

  • (H30053)  4-Benzyloxy-1-bromo-2-fluorobenzene, 98%   

  • 185346-79-6

  • 25g

  • 1369.0CNY

  • Detail

185346-79-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-bromo-2-fluoro-4-phenylmethoxybenzene

1.2 Other means of identification

Product number -
Other names PC8332

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:185346-79-6 SDS

185346-79-6Relevant articles and documents

COMPOUNDS FOR TARGETED DEGRADATION OF BRD9

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Page/Page column 590-591; 618-619, (2021/09/11)

BRD9 protein degradation compounds or pharmaceutically acceptable salts thereof are provided for the treatment of disorders mediated by BRD9, including but not limited to abnormal cellular proliferation.

MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE

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Paragraph 00480, (2018/08/20)

The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition

Li, Yi-Xian,Iwaki, Ren,Kato, Atsushi,Jia, Yue-Mei,Fleet, George W. J.,Zhao, Xuan,Xiao, Min,Yu, Chu-Yi

, p. 1429 - 1438 (2016/03/16)

Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.

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