19745-72-3Relevant articles and documents
Synthetic method for tyramine hydrochloride
-
Paragraph 0030; 0031; 0032, (2017/01/31)
The invention discloses a synthetic method for tyramine hydrochloride. The synthetic method includes the steps that phenol is used as a raw material and reacts with aminoacetonitrile to generate p-hydroxy phenylaminoethanol, p-hydroxy phenylaminoethanol is subjected to catalytic reduction to obtain tyramine hydrochloride, activated carbon and copper powder are used as a composite catalyst, and the mass ratio of the activated carbon to the copper powder is (3-5):1. As the activated carbon and copper powder composite catalyst is added, the ratio of the dosage of the catalyst to the substrate weight can be reduced to (0.1-0.2):1. The catalytic efficiency is improved remarkably, the number of times of continuously using the catalyst can be increased to be 10 or more, the total yield of the reactions is increased, and the synthetic method has high economic benefits.
Discovery and synthesis of a novel series of liver X receptor antagonists
Nian, Siyun,Gan, Xia,Tan, Xiangduan,Yu, Zhenpeng,Wang, Panfeng,Chen, Xing,Wang, Guoping
, p. 628 - 635 (2015/09/07)
Fourteen novel compounds were prepared and their antagonistic activities against liver X receptors (LXR) α/β were tested in vitro. Compound 26 had an IC50 value of 6.4 μM against LXRα and an IC50 value of 5.6 μM against LXRβ. Docking studies and the results of structure-activity relationships support the further development of this chemical series as LXRα/β antagonists.