49769-82-6Relevant articles and documents
Reductive Knoevenagel Condensation with the Zn-AcOH System
Ivanov, Konstantin L.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
, p. 1285 - 1291 (2020/11/13)
An efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn-AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.
A Facile one-pot benzylation of sodium enolates using trifluoromethanesulfonic anhydride and diphenyl sulfoxide
Takuwa, Tomofumi,Minowa, Tomofumi,Fujisawa, Hidehiko,Mukaiyama, Teruaki
, p. 476 - 480 (2007/10/03)
A facile one-pot C-benzylation of various sodium enolates derived from methyl malonate, β-ketoesters, a β-cyanoester, a β-cyanosulfone, ketones and a carboxylic ester is reported. Reaction of alkoxydiphenylsulfonium salts formed by treating various benzyl alcohols with diphenyl sulfide bis(trifluoromethanesulfonate) (derived from trifluoromethanesulfonic anhydride and diphenyl sulfoxide) proceeded smoothly, and the corresponding C-benzylated products were afforded in good to high yields.
Methyl Trideuteriomethyl (E)-(α-Bromoarylidene)malonates: Simple Stereochemical Probes in Nucleophilic Vinylic Substitution near the Retention/Stereoconvergence Borderline
Rappoport, Zvi,Gazit, Aviv
, p. 6698 - 6710 (2007/10/02)
Methyl trideuteriomethyl (E)-(α-bromo-p-methyl- and -p-nitrobenzylidene)malonates (4 and 5) were prepared.These electrophilic bromo olefins are activated to vinylic substitution by ywo chemically identical but isotopically distinguishable CO2Me groups.The
