698-19-1Relevant articles and documents
Multi-substituted amine compound and its preparation and use (by machine translation)
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Paragraph 0208; 0507; 0509; 0511; 0512, (2018/04/27)
The invention belongs to the field of medical technology, in particular, the present invention provides the following formula I shown multi-substituted amine compound or its isomer or its pharmaceutically acceptable salt, ester, prodrug or hydrate, its pharmaceutical composition, preparation method thereof and its use in the preparation of medicine for treating aids in use. The compound or pharmaceutical composition containing the compound can be used as an inhibitor for inhibiting HIV integrase with LEDGF/p75 between protein - protein interaction and HIV integrase dimerization, then can be used for the treatment of aids. . (by machine translation)
Highly enantioselective organocatalytic trifluoromethyl carbinol synthesis-a caveat on reaction times and product isolation
Duangdee, Nongnaphat,Harnying, Wacharee,Rulli, Giuseppe,Neudoerfl, Joerg-M.,Groeger, Harald,Berkessel, Albrecht
experimental part, p. 11196 - 11205 (2012/08/28)
Aldol reactions with trifluoroacetophenones as acceptors yield chiral α-aryl, α-trifluoromethyl tertiary alcohols, valuable intermediates in organic synthesis. Of the various organocatalysts examined, Singh's catalyst [(2S)-N-[(1S)-1-hydroxydiphenylmethyl
Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4- dihydroisoquinolin-3-ones
Ma, Ting,Chen, Wenteng,Zhang, Guolin,Yu, Yongping
scheme or table, p. 488 - 490 (2010/09/05)
An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of