A New Reagent for the Selective, High-Yield N-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine

DOI: 10.1021/jo00185a072

Source and publish data:

Journal of Organic Chemistry p. 2081 - 2082 (1984)

Update date:2022-08-11

Topics:

Authors:

Olofson, R. A.

Martz, Jonathan T.

Senet, Jean-Pierre

Piteau, Marc

Malfroot, Thierry

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Article abstract of DOI:10.1021/jo00185a072

Secondary amine hydrochlorides are obtained in high yield by reaction of tertiary amines with α-chloroethyl chloroformate followed by warming the intermediate carbamate in methanol.

Full text of DOI:10.1021/jo00185a072

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