100256-51-7

Upstream product

• 286-20-4 cyclohexene oxide 
• 139-02-6 sodium phenoxide 
• 110-83-8 cyclohexene 
• 108-95-2 phenol 
• 100-02-7 4-nitro-phenol 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 14004-19-4 2-phenoxycyclohexanone 
• 169527-71-3 2-(4-tert-butylphenoxy)cyclohexanol 

Relevant academic research and scientific papers

Activation of hydrogen peroxide through hydrogen-bonding interaction with acidic alcohols: Epoxidation of alkenes in phenol

(Matrix presented) Electrophilic activation of hydrogen peroxide can be achieved in acidic alcohol solvents without the need for a metal catalyst. This concept is illustrated by the epoxidation of alkenes with H2O 2 employing phenol as a solvent. It is proposed that intermolecular hydrogen bonding between H2O2 and phenol activates H 2O2 for oxygen-atom transfer. In this interaction, the role of phenol is purely catalytic.

3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.

Preparation method of 2-(4-tert-butyl phenoxy) cyclohexanol

The invention, aiming at problems in current preparation of a propargite technical intermediate namely 2-(4-tert-butyl phenoxy) cyclohexanol, provides a preparation method of 2-(4-tert-butyl phenoxy) cyclohexanol. According to the preparation method, cond

Erbium(III) triflate is a highly efficient catalyst for the synthesis of β-alkoxy alcohols, 1,2-diols and β-hydroxy sulfides by ring opening of epoxides

Chemo- and stereoselectivity in the ring-opening reaction of epoxides with erbium(III) triflate are described. Epoxides can be cleaved under neutral conditions with alcohols and thiols in the presence of catalytic amounts of Lewis acid, affording the corresponding β-alkoxy alcohols and β-hydroxy sulfides in high yields. In water, epoxide ring opening occurs to produce the corresponding diols in good yields.

Bi(OTf)3-catalyzed regioselective ring opening of epoxides with phenols: Facile synthesis of 1,3-diaryloxy-2-propanols

Substituted aryl oxiranes undergo the facile ring opening with phenols in the presence of catalytic amount of bismuth(III) triflate to afford 1,3-diaryloxy-2-propanols in excellent yields under mild conditions. Bismuth(III) triflate is relatively non-toxic, easy to handle and inexpensive, which makes this procedure particularly attractive for large scale synthesis. Copyright

Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors

Compounds of the formula; are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such compounds,

Ring opening of epoxides with carboxylates and phenoxides in micellar media catalyzed with Ce(OTf)4

Efficient ring opening reaction of epoxides with carboxylates and phenoxide anions catalyzed with ceric triflate is performed in micellar media. This new method is a useful procedure for the preparation of β-carboxy and phenoxy alcohols from epoxides under mild reaction conditions.