100337-62-0Relevant academic research and scientific papers
Metal-free Mizoroki-Heck type reaction: A radical oxidative coupling reaction of 2-chloro-dithiane with substituted olefins
Du, Wenbin,Lai, Junshan,Tian, Lixia,Xie, Xingang,She, Xuegong,Tang, Shouchu
, p. 14017 - 14020 (2014)
An efficient metal-free Mizoroki-Heck type reaction of di- and tri-substituted alkenes with 2-chloro-dithiane has been developed under ambient pressure of air or using a relatively low loading of BF3·Et2O. This study represents a new environmentally friendly method for the syntheses of dithianyl-substituted alkene derivatives via a radical oxidative coupling process.
Copper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins
Kortman, Gregory D.,Hull, Kami L.
, p. 6220 - 6224 (2017/09/15)
The copper-catalyzed hydroarylation of internal, unsymmeric alkynes is presented. Trisubstituted alkenes are obtained as single diastereomers in good to excellent yields and excellent regioselectivities. The scope of the reaction is presented with respect to alkyne and aryl iodide coupling partners. Initial mechanistic experiments indicate a hydrocupration event followed by a two-electron oxidative addition/reductive elimination pathway.
Efficient synthesis of polysubstituted olefins using stable palladium nanocatalyst: Applications in synthesis of tamoxifen and isocombretastatin A4
Ganapathy, Dhandapani,Sekar, Govindasamy
supporting information, p. 3856 - 3859 (2014/08/18)
A phosphine-free stable palladium nanocatalyst was used for an efficient synthesis of polysubstituted olefins from N-tosylhydrazones and aryl iodides. This methodology was successfully utilized in the synthesis of biologically important tamoxifen and isocombretastatin A4. The nanocatalyst was easily recovered and reused without any apparent loss in size and catalytic activity.
Palladium catalyzed coupling of tosylhydrazones with aryl and heteroaryl halides in the absence of external ligands: Synthesis of substituted olefins
Ojha, Devi Prasan,Prabhu, Kandikere Ramaiah
, p. 11027 - 11033 (2013/02/22)
Palladium catalyzed cross-coupling reaction of hydrazones with aryl halides in the absence of external ligand is reported. The versatility of this coupling reaction is demonstrated in showcasing the selectivity of coupling reaction in the presence of hydr
Friedel-Crafts alkenylation of arenes using alkynes catalysed by metal trifluoromethanesulfonates
Tsuchimoto,Maeda,Shirakawa,Kawakami
, p. 1573 - 1574 (2007/10/03)
Metal trifluoromethanesulfonates [M(OTf)(n); M = Sc, Zr, In] catalyse the Friedel-Crafts alkenylation of arenes using alkynes, including internal alkynes, to give, through an alkenyl cation intermediate, 1,1-diarylalkenes in high to excellent yields.
