17336-66-2

Basic information

• Product Name: 1-PROPIOPHENONE TOSYLHYDRAZONE 97
• Synonyms: 1-PROPIOPHENONE TOSYLHYDRAZONE 97;4-methyl-N'-((1E)-1-phenylpropylidene)benzenesulfonohydrazide;Propionophenone p-toluenesulfonylhydrazone;PROPIOPHENONE (P-TOSYL)HYDRAZONE;4-methyl-N-[(Z)-1-phenylpropylideneamino]benzenesulfonamide
• CAS NO: 17336-66-2
• Molecular Formula: C₁₆H₁₈N₂O₂S
• Molecular Weight: 302.39132
• Mol File: 17336-66-2.mol
• Article Data: 25

Chemical Properties

• Melting Point: 118-120 °C(lit.)
• Boiling Point: 448.4±38.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• PKA: 9.81±0.40(Predicted)
• CAS DataBase Reference: 1-PROPIOPHENONE TOSYLHYDRAZONE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PROPIOPHENONE TOSYLHYDRAZONE 97(17336-66-2)
• EPA Substance Registry System: 1-PROPIOPHENONE TOSYLHYDRAZONE 97(17336-66-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 17336-66-2(Hazardous Substances Data)

Usage

General Description

1-Propiophenone tosylhydrazone 97 is a chemical compound with the molecular formula C13H16N2O3S. It is a tosylhydrazone derivative of 1-propiophenone, with a molecular weight of 272.34 g/mol. 1-PROPIOPHENONE TOSYLHYDRAZONE 97 is commonly used in organic synthesis as a reagent for the conversion of ketones to the corresponding hydrazones. It can also be used as a chelating agent in coordination chemistry and as a ligand in the synthesis of coordination compounds. 1-Propiophenone tosylhydrazone 97 is a white to off-white crystalline powder with a melting point of 192-195°C and is known to be stable under normal conditions.

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Relevant articles and documents

TRICYCLIC COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 (GSK3) INHIBITORS AND USES THEREOF

The present disclosure provides compounds of Formula (I), and salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be useful for inhibiting kinases

Pd-Catalyzed Alkenyl Thioether Synthesis from Thioesters and N-Tosylhydrazones

A Pd-catalyzed alkenyl thioether synthesis was achieved using thioesters and N-tosylhydrazones as starting materials. The thioester acted as an efficient "sulfur source" for catalytic C-S bond formation using N-tosylhydrazone. This method gave Z-alkenyl thioethers with high diastereoselectivity (up to 99:1 diastereomeric ratio). This transformation displayed a wide functional group tolerance and was successfully applied to the late-stage derivatization of a pharmaceutical molecule to the corresponding alkenyl thioether.

Cooperative Iodide Pd(0)-Catalysed Coupling of Alkoxyallenes and N-Tosylhydrazones: A Selective Synthesis of Conjugated and Skipped Dienes

Palladium(0)-catalysed hydro-alkylation or -alkenylation of alkoxyallenes with N-tosylhydrazones gives direct access to conjugated and skipped 1-alkoxydienes with high efficiency and excellent functional-group compatibility. The reaction is proposed to in