1005489-96-2

Upstream product

• 1005490-16-3 2-amino-N-(4-iodophenyl)nicotinamide 
• 115-80-0 Triethyl orthopropionate 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 1005490-37-8 2-(1-chloroethyl)-3-(4-iodophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1005490-33-4 4-(2-ethyl-4-oxopyrido[2,3-d]pyrimidin-4(3H)-yl)benzonitrile 
• 1005490-35-6 3-(4-cyanophenyl)-2-ethylpyrido[2,3-d]pyrimidin-4(3H)-one 
• 947536-15-4 rac-4-[2-(1-amino-ethyl)-4-oxo-4H-pyrido[2,3-d]pyrimidin-3-yl]-benzonitrile 
• 873191-26-5 (R)-4-(2-(1-aminoethyI)-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)benzonitrile 
• 1355478-91-9 C₁₆H₁₁ClN₄O 

Relevant academic research and scientific papers

Discovery of potent and specific CXCR3 antagonists

The optimization of a series of 8-aza-quinazolinone analogs for antagonist activity against the CXCR3 receptor is reported. Compounds were optimized to avoid the formation of active metabolites and time-dependent-inhibitors of CYP3A4. In addition, antagon

Acetic acid mediated coupling of 2-aminonicotinamides with ortho esters: A convenient, scalable synthesis of 2,3-substituted pyrido[2,3-d]pyrimidines

Substituted pyrido[2,3-d]pyrimidines are synthesized in good to excellent yields by treatment of various 2-aminonicotinamides with triethyl orthopropionate or triethyl orthoacetate in the presence of acetic acid. Georg Thieme Verlag Stuttgart.