1355478-91-9Relevant academic research and scientific papers
Discovery of potent and specific CXCR3 antagonists
Chen, Xiaoqi,Mihalic, Jeff,Deignan, Jeff,Gustin, Darin J.,Duquette, Jason,Du, Xiaohui,Chan, Johann,Fu, Zice,Johnson, Michael,Li, An-Rong,Henne, Kirk,Sullivan, Tim,Lemon, Bryan,Ma, Ji,Miao, Shichang,Tonn, George,Collins, Tassie,Medina, Julio C.
, p. 357 - 362 (2012/03/11)
The optimization of a series of 8-aza-quinazolinone analogs for antagonist activity against the CXCR3 receptor is reported. Compounds were optimized to avoid the formation of active metabolites and time-dependent-inhibitors of CYP3A4. In addition, antagon
