947536-15-4

Upstream product

• 540-37-4 p-aminoiodobenzene 
• 1355478-91-9 C₁₆H₁₁ClN₄O 
• 1005490-33-4 4-(2-ethyl-4-oxopyrido[2,3-d]pyrimidin-4(3H)-yl)benzonitrile 
• 1005489-96-2 2-ethyl-3-(4-iodophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1005490-16-3 2-amino-N-(4-iodophenyl)nicotinamide 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 873191-24-3 (R)-{1-[3-(4-iodo-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-89-7 (R)-[1-(4-oxo-4H-pyrido[2,3-d][1,3]oxazin-2-yl)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 873191-26-5 (R)-4-(2-(1-aminoethyI)-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)benzonitrile 
• 947536-17-6 rac-4-(4-oxo-2-{1-[(pyridin-3-ylmethyl)-amino]-ethyl}-3H-pyrido[2,3-d]pyrimidin-3-yl)-benzonitrile 

Relevant academic research and scientific papers

Discovery of potent and specific CXCR3 antagonists

The optimization of a series of 8-aza-quinazolinone analogs for antagonist activity against the CXCR3 receptor is reported. Compounds were optimized to avoid the formation of active metabolites and time-dependent-inhibitors of CYP3A4. In addition, antagon

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid {1-[3-(4-cyano-pheny