873191-26-5

Upstream product

• 873191-25-4 {1-[3-(4-cyano-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 947536-15-4 rac-4-[2-(1-amino-ethyl)-4-oxo-4H-pyrido[2,3-d]pyrimidin-3-yl]-benzonitrile 
• 1005490-16-3 2-amino-N-(4-iodophenyl)nicotinamide 
• 1005489-96-2 2-ethyl-3-(4-iodophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one 
• 1005490-33-4 4-(2-ethyl-4-oxopyrido[2,3-d]pyrimidin-4(3H)-yl)benzonitrile 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 1355478-91-9 C₁₆H₁₁ClN₄O 
• 540-37-4 p-aminoiodobenzene 

Relevant academic research and scientific papers

Discovery of potent and specific CXCR3 antagonists

The optimization of a series of 8-aza-quinazolinone analogs for antagonist activity against the CXCR3 receptor is reported. Compounds were optimized to avoid the formation of active metabolites and time-dependent-inhibitors of CYP3A4. In addition, antagon

Optimization of a series of quinazolinone-derived antagonists of CXCR3

The evaluation of the CXCR3 antagonist AMG 487 in clinic trials was complicated due to the formation of an active metabolite. In this Letter, we will discuss the further optimization of the quinazolinone series that led to the discovery of compounds devoi

ARYL NITRILE COMPOUNDS AND COMPOSITIONS AND THEIR USES IN TREATING INFLAMMATORY AND RELATED DISORDERS

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a ch

FUSED PYRIMIDINE DERIVATIVES AND COMPOSITIONS THEREOF AS CXCR3 RECEPTOR MODULATORS, USEFUL IN PREVENTION AND TREATMENT OF INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES

Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.