1190360-14-5Relevant articles and documents
Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: Identification of potent Bcl-xL inhibitors
Yap, Jeremy L.,Cao, Xiaobo,Vanommeslaeghe, Kenno,Jung, Kwan-Young,Peddaboina, Chander,Wilder, Paul T.,Nan, Anjan,MacKerell, Alexander D.,Smythe, W. Roy,Fletcher, Steven
, p. 2928 - 2933 (2012/05/07)
By conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based α-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-xL. The most potent compound has a Ki value of 94 nM in vitro, and single-digit micromolar IC50 values against the proliferation of several Bcl-xL-overexpressing cancer cell lines. The Royal Society of Chemistry 2012.
Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction
Plante, Jeffrey P.,Burnley, Thomas,Malkova, Barbora,Webb, Michael E.,Warriner, Stuart L.,Edwards, Thomas A.,Wilson, Andrew J.
supporting information; experimental part, p. 5091 - 5093 (2009/12/08)
Oligobenzamide inhibitors of the p53-hDM2 protein-protein interaction are described. The Royal Society of Chemistry 2009.
