100623-16-3

Basic information

• Product Name: 3-chloro-4-methoxyphenyl benzoate
• CAS NO: 100623-16-3
• Molecular Weight: 262.693
• Mol File: 100623-16-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-methoxyphenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-methoxyphenyl benzoate(100623-16-3)
• EPA Substance Registry System: 3-chloro-4-methoxyphenyl benzoate(100623-16-3)

Safety Data

• Hazardous Substances Data: 100623-16-3(Hazardous Substances Data)

Upstream product

• 2267-25-6 2-chloro-4-fluoro-1-methoxy-benzene 
• 65-85-0 benzoic acid 
• 18093-12-4 3-chloro-4-methoxyphenol 
• 98-88-4 benzoyl chloride 
• 1523-19-9 4-methoxyphenyl benzoate 

Downstream Products

• 18093-12-4 3-chloro-4-methoxyphenol 

Relevant articles and documents

Nucleophilic aromatic substitution of unactivated fluoroarenes enabled by organic photoredox catalysis

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics.