100716-06-1Relevant articles and documents
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
?z?elik, Azime Berna,?zdemir, Zeynep,Sari, Suat,Utku, Semra,Uysal, Mehtap
, p. 1253 - 1263 (2019)
Background: The pyridazinone nucleus has been incorporated into a wide variety of therapeutically interesting molecules to transform them into better drugs. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh). Inhibition of cholinesterases is an effective method to curb Alzheimer's disease. Here, we prepared 12 new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(nonsubstituted/4-substituted benzenesulfonohydrazide) derivatives and evaluated their inhibitory effects on AChE/BChE in pursuit of potent dual inhibitors for Alzheirmer's Disease. We also tried to get insights into binding interactions of the synthesized compounds in the active site of both enzymes by using molecular docking approach. Method: We obtained our compounds by the reaction of various substituted/nonsubstituted benzenesulfonic acid derivatives with 6-substitutedphenyl-3(2H)-pyridazinone-2-yl acetohydrazide and determined their anticholinesterase activities according to the Ellman's method. Molecular docking studies were done using Glide and the results were evaluated on Maestro (Schr?dinger, LLC, New York, NY, 2019). Results: The title compounds showed moderate inhibition at 100 μg/ml against both enzymes, yet with better activity against BChE. Compound VI2a emerged as a dual inhibitor with 25.02% and 51.70% inhibition against AChE and BChE, respectively. Conclusion: This study supports that novel pyridazinone derivates may be used for the development of new BChE inhibitory agents. It was less potent than the reference drugs, yet promising for further modifications as a lead. The ability of the compounds to adopt energetically more favourable conformations and to engage in more key interactions in the ECBChE active gorge explains their better activity profile against ECBChE.
Synthesis of novel heterocyclic compounds with expected antibacterial activities from 4-(4-bromophenyl)-4-oxobut-2-enoic acid
El-Hashash, Maher A.,Soliman, Ahmed Y.,Bakeer, Hadeer M.,Mohammed, Fatehia K.,Hassan, Haitham
, p. 732 - 743 (2015/05/13)
This research describes the utility of 4-(4-bromophenyl)-4-oxobut-2-enoic acid as a key starting material for preparation of a novel series of aroylacrylic acids, pyridazinones, and furanones derivatives. These heterocyclic compounds were synthesized by r
Synthesis and antituberculosis activity of some new pyridazine derivatives. Part II
Mantu, Dorina,Cǎtǎlina Luca, Mihaela,Moldoveanu, Costel,Zbancioc, Gheorghita,Mangalagiu, Ionel I.
experimental part, p. 5164 - 5168 (2010/11/19)
A series of eighteen novel compounds with pyridazine moiety were synthesized and their in vitro antituberculosis activities have been evaluated. A fast, general, and facile method for preparation of pyridazine derivatives in moderate to excellent yields i
Utility of β-aroyl acrylic acid in heterocyclic synthesis
Rizk,El-Hashash,Mostafa
experimental part, p. 611 - 621 (2010/09/05)
β-(4-bromobenzoyl) acrylic acid has been reacted with nitrogen nucleophiles namely ethanolamine and o-aminophenol and yielded the corresponding adduct la,b. On the other hand, ss-(3,4dichlorobenzoyl) acrylic acid has been reacted with carbon nucleophiles
