100980-82-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Hydroxyphenyl)benzaldehyde is used as a reagent for the discovery of nonpeptide inhibitors of stromelysin. It plays a crucial role in understanding the structure-activity relationship by Nuclear Magnetic Resonance (NMR) techniques, which aids in the development of new drugs targeting specific enzymes.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(4-Hydroxyphenyl)benzaldehyde is utilized for the preparation of nitroimidazole heterocyclic compounds. These compounds have potential applications in the treatment of tuberculosis, offering a new avenue for the development of more effective anti-tuberculosis drugs.

Upstream product

• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 106-41-2 4-bromo-phenol 
• 87199-17-5 4-formylphenylboronic acid, 
• 540-38-5 p-Iodophenol 
• 52988-34-8 4-(4'-methoxyphenyl)benzaldehyde 
• 5720-07-0 4-methoxyphenylboronic acid 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 716344-19-3 4'-(tert-butyl-dimethyl-silanyloxy)-biphenyl-4-carbaldehyde 
• 2403-54-5 2-(4-chlorophenyl)-1,3-dioxolane 
• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 

Downstream Products

• 83327-38-2 [1-(4'-Octyloxy-biphenyl-4-yl)-meth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine 
• 1611443-81-2 4’-(4-(trifluoromethyl)cyclohexyloxy)biphenyl-4-carbaldehyde 
• 1611443-82-3 4’-(4-(trifluoromethyl)cyclohexyloxy)biphenyl-4-carboxylic acid 
• 1611445-30-7 (S)-1-(4’-(4-(trifluoromethyl)cyclohexyloxy)biphenylcarbonyl)pyrrolidine-3-carboxylic acid 
• 1296131-52-6 (4-biphenyl)methyl 3,5,9-trideoxy-5-glycolamido-9-(4'-hydroxy-4-biphenyl) methylamino-D-glycero-α-D-galacto-2-nonulopyranosidonic acid 
• 1296131-50-4 benzyl 3,5,9-trideoxy-5-glycolamido-9-(4'-hydroxy-4-biphenyl)methylamino-D-glycero-α-D-galacto-2-nonulopyranosidonic acid 
• 1072896-70-8 p-methoxyphenyl (3,5,9-trideoxy-5-glycolamido-9-(4'-hydroxy-4-biphenyl)-methylamino-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside 

Relevant academic research and scientific papers

Mesomorphism, polymerization, and chirality induction in α-cyanostilbene-functionalized diacetylene-assembled films: Photo-triggered Z/E isomerization

Engineering of molecular stacking arrangement via environmental stimuli is of particular interest in stimuli-responsive self-assembling architectures. A novel dual photo-functionalized diacetylene ((Z)-CNBE-DA) molecule was synthesized, in which photo-res

Catalytic activity of recyclable resorcinarene-protected antibacterial Pd nanoparticles in C-C coupling reactions

Novel tetra-methoxy resorcinarene tetra-hydrazide (TMRTH) has been synthesized and used as a reducing agent and a capping agent for the synthesis of water-dispersible stable palladium nanoparticles (PdNPs). The TMRTH-PdNPs were characterized by UV-Vis spectroscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and powder X-ray diffraction. The synthesized nanoparticles are polydispersible with a size of 5 ± 2 nm and were found to be recyclable over five cycles maintaining a catalytic activity in the Suzuki-Miyuara cross-coupling reaction. The nanocatalyst was superior in catalytic performance to conventional palladium catalysts with respect to reaction time, catalyst loading and recyclability. TMRTH-PdNPs show promise for their use in biological applications as they exhibit good antibacterial activity against gram-positive bacteria.

Pd(l -proline)2 complex: An efficient catalyst for Suzuki-Miyaura coupling reaction in neat water

An efficient catalytic system for Suzuki-Miyaura coupling reactions in neat water has been developed by using a water-soluble Pd(l-proline)2 catalyst. Under the optimized conditions, various biaryl compounds were obtained in good to excellent yields and a wide range of functional groups on the tested substrates were well tolerated. The catalytic system could be reused at least six times with no significant loss in its activity.

Ionic Liquid Acceleration of Solid-Phase Suzuki-Miyaura Cross-Coupling Reactions

(Equation Presented) Room-temperature ionic liquids promote various transition metal-catalyzed reactions in the solution phase. Here, for the first time, we show that these effects are translatable to solid-phase reactions. The Suzuki-Miyaura cross-coupli

Formation of an interlocked double-chain from an organic-inorganic [2]rotaxane

Here we show that a structure containing a polymeric interlocking daisy chain is obtained from the reaction of an inorganic-organic [2]rotaxane [HB{CrIII7NiII(μ-F)8(O2CtBu)16}], where B is an organic thread terminated with a bi-pyridyl unit, with an oxo-centered metal carboxylate triangle [FeIII2CoII(μ3-O)(O2CtBu)6(HO2CtBu)3].

A one-pot protocol for the fluorosulfonation and Suzuki coupling of phenols and bromophenols, streamlined access to biaryls and terphenyls

A one-pot protocol for the fluorosulfation and Suzuki coupling of phenols is described. The tandem reaction proceeds efficiently at room temperature, and various biaryls and biaryl fluorosulfates were obtained in good to excellent yields. Furthermore, biaryl fluorosulfates were utilized as versatile building blocks for the preparation of terphenyls. The Royal Society of Chemistry 2020.

An acetatopalladium(II) complex with 1-benzyl-N-(3,5-di-tert-butylsalicylidene)piperidin-4-amine: Synthesis, structure and catalytic applications in Suzuki–Miyaura coupling of arylboronic acids with hydroxyaryl halides

The Schiff base 1-benzyl-N-(3,5-di-tert-butylsalicylidene)piperidin-4-amine (HL) and its acetatopalladium(II) complex having the formula [Pd(L)(OAc)] were synthesized. Both HL and [Pd(L)(OAc)] were characterized using elemental analysis and various spectroscopic (infrared, UV–visible, 1H NMR and 13C NMR) and mass spectrometric measurements. The molecular structure of the complex was determined using X-ray crystallographic analysis. In the complex, the pincer-like NNO-donor L? and the monodenate OAc? provide a distorted square-planar N2O2 coordination environment around the metal centre. The physicochemical properties and the spectroscopic features of [Pd(L)(OAc)] are consistent with its molecular structure. The complex was found to be an effective catalyst for the Suzuki–Miyaura cross-coupling reactions of hydroxyaryl halides with arylboronic acids in predominantly aqueous media. The reactions afforded hydroxybiaryl products in good to excellent yields with a wide substrate scope.

INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME

Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.

Concentration-dependent and light-responsive self-assembly of bolaamphiphiles bearing α-cyanostilbene based photochromophore

In this paper, a new bolaamphiphile bearing 1-cyano-1,2-bis(phenyl)ethene (CNBE) has been synthesized. The self-assembly of this molecule in aqueous solution is concentration-dependent. Two distinct morphologies, monomolecular layered lamellas and helical

An oxidatively-activated safety catch linker for solid phase synthesis

A N-benzyl-4-amino-2,2-dimethylbutanoic acid-based system has been developed as a new oxidatively activated safety catch linker for reaction monitoring and optimisation on solid support. The CAN promoted oxidative debenzylation of the tertiary N-benzylamine moiety, followed by concomitant cyclisation and release of alcohols and amines has been demonstrated both in solution phase model studies and on the solid phase. The linker system has been applied to the solid phase synthesis of a collection of phenol derivatives, and to the demonstration of the attachment and release of a chiral auxiliary from a solid support. The Royal Society of Chemistry 2008.