141452-01-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl indoline-5-carboxylate is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs due to its unique structural properties.
Used in Agrochemical Production:
In the agrochemical industry, methyl indoline-5-carboxylate is utilized as a precursor in the creation of compounds that can protect crops from pests and diseases, leveraging its reactivity in chemical reactions.
Used in Fine Chemicals Industry:
Methyl indoline-5-carboxylate is employed as a key component in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including fragrances, dyes, and other specialty products.
Used as a Precursor in Organic Compound Preparation:
Methyl indoline-5-carboxylate is used as a precursor for the preparation of various organic compounds through chemical reactions such as esterification or amidation, broadening its applications in organic chemistry.
Used in Antifungal and Antimicrobial Applications:
Methyl indoline-5-carboxylate has been studied for its potential biological activities, including its use as an antifungal and antimicrobial agent, indicating its possible role in healthcare and sanitation products.

InChI:InChI=1/C10H11NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-3,6,11H,4-5H2,1H3

Upstream product

• 153497-12-2 methyl 1-acetylindoline-5-carboxylate 
• 1011-65-0 5-methoxycarbonylindole 
• 7664-93-9 sulfuric acid 
• 67-56-1 methanol 
• 15861-30-0 2,3-dihydro-1H-indole-5-formic acid 
• 153247-93-9 1-acetylindoline-5-carboxylic acid 
• 16078-30-1 1-Acetyl-2,3-dihydro-1H-indole 

Downstream Products

• 15861-30-0 2,3-dihydro-1H-indole-5-formic acid 
• 720684-10-6 1-(4'-Trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester 
• 849235-63-8 methyl 1-(3,4,5-trimethoxy-benzyl)-2,3-dihydro-1H-indole-5-carboxylate 
• 1087243-25-1 methyl 1-tosylindoline-5-carboxylate 
• 1087243-27-3 C₁₆H₁₄N₂O₆S 
• 1620581-36-3 methyl 1-((3-(4-cyano-2,6-dimethylheptan-4-yl)-4-methoxyphenyl)sulfonyl)indoline-5-carboxylate 

Relevant academic research and scientific papers

Rh(III)-Catalyzed C7-Thiolation and Selenation of Indolines

The rhodium(III)-catalyzed intermolecular C7-thiolation and selenation of indolines with disulfides and diselenides were developed. This protocol relies on the use of a removable pyrimidyl directing group to access valuable C-7 functionalized indoline scaffolds with ample substrate scope and broad functional group tolerance.

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

This study focused on the substitution effect at position C7 of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines. Compound 9, (E)-3-(7-amino-1-(4-methoxyphenylsulfonyl)indolin-5-yl)-N-hydroxyacrylamide, displayed 4- to 14-fold more potent antiproliferative

Pd/C-Catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiboron as the hydrogen source

Under the guidance of the known mechanism of the hydrogenation of indoles and transfer hydrogenation with tetrahydroxydiboron (B2(OH)4), Pd/C catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiborane as the hydrogen source has been developed. This provides an efficient strategy and catalytic system for the reduction of un-activatedN-H indoles, andN-H indolines are obtained with good to excellent yields. In addition, a series of the isotopic labelling experiments were carried out to probe the mechanism.

Expedient cobalt(II)-catalyzed site-selective C7-arylation of indolines with arylboronic acids

Cobalt(ii)-catalyzed pyrimidyl directing group-assisted C7 arylation of indolines with arylboronic acids has been developed using Mn(OAc)2·4H2O as an oxidant. The use of cobalt(ii)-PCy3 as a catalyst and broad substrate scope are the important practical features.

Heterogeneous catalytic hydrogenation of unprotected indoles in water: A green solution to a long-standing challenge

An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields.

PGDH INHIBITORS AND METHODS OF MAKING AND USING

Disclosed herein are compounds that can inhibit 15-hydroxyprostaglandin dehydrogenase. Such compounds may be administered to subjects that may benefit from modulation of prostaglandin levels.

Manganese(III) Acetate Catalyzed Aerobic Dehydrogenation of Tertiary Indolines, Tetrahydroquinolines and an N-Unsubstituted Indoline

A Mn(OAc)3 ? 2H2O-catalyzed aerobic dehydrogenation of five and six-membered N-heterocycles for the synthesis of N-heteroarenes is reported. Of note, this protocol can be applied to the dehydrogenation of tertiary indolines with various electron-deficient N-substituents. Preliminary mechanistic investigations support that a single-electron transfer pathway might be involved. (Figure presented.).

Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex

A highly chemoselective base-metal catalyzed hydrogenation and acceptorless dehydrogenation of N-heterocycles is presented. A well-defined Mn complex operates at low catalyst loading (as low as 2 mol %) and under mild reaction conditions. The described catalytic system tolerates various functional groups, and the corresponding reduced heterocycles can be obtained in high yields. Experimental studies indicate a metal-ligand cooperative catalysis mechanism.

Aerobic Dehydrogenation of N-Heterocycles with Grubbs Catalyst: Its Application to Assisted-Tandem Catalysis to Construct N-Containing Fused Heteroarenes

An aerobic dehydrogenation of nitrogen-containing heterocycles catalyzed by Grubbs catalyst is developed. The reaction is applicable to various nitrogen-containing heterocycles. The exceptionally high functional group compatibility of this method was confirmed by the oxidation of an unprotected dihydroindolactam V to indolactam V. Furthermore, by taking advantage of the oxygen-mediated structural change of the Grubbs catalyst, we integrated ring-closing metathesis and subsequent aerobic dehydrogenation to develop the novel assisted-tandem catalysis using molecular oxygen as a chemical trigger. The utility of the assisted-tandem catalysis was demonstrated by the concise synthesis of N-containing fused heteroarenes including a natural antibiotic, pyocyanine.

HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS

The present application discloses heterobicyclic and non-heterobicyclic aromatic derivative compounds and compositions, and methods for treating ferroptosis-related disorders and diseases in patients using the compounds and compositions as disclosed herei